A5077304751- Genetic Associations and Epidemiology
- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Adipokines, Inflammation, and Metabolic Diseases
- Insect Utilization and Effects
- Biochemical Analysis and Sensing Techniques
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Chronic Kidney Disease and Diabetes
- Adenosine and Purinergic Signaling
- Aquaculture Nutrition and Growth
- Renin-Angiotensin System Studies
- Genetic and phenotypic traits in livestock
- Cytokine Signaling Pathways and Interactions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Epigenetics and DNA Methylation
- Diabetes Treatment and Management
- Invertebrate Immune Response Mechanisms
- Physiological and biochemical adaptations
- Obesity, Physical Activity, Diet
- Lipid metabolism and disorders
- Genetic Mapping and Diversity in Plants and Animals
University of Louisiana at Monroe
2017-2021
Google (United States)
2015
Wake Forest University
2008-2012
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of study was to identify genes associated with the American population. We performed a Genome Wide Association Study (GWAS) Affymetrix 6.0 array 965 African-American cases and end-stage renal disease (T2DM-ESRD) 1029 population-based controls. most significant SNPs (n = 550 independent loci) were genotyped...
We investigated candidate genomic regions associated with computed tomography (CT)-derived measures of adiposity in Hispanics from the Insulin Resistance Atherosclerosis Study Family (IRASFS). In 1,190 Hispanic individuals 92 families 3 San Luis Valley, Colorado and Antonio, Texas, we measured CT-derived visceral adipose tissue (VAT), subcutaneous (SAT), visceral:subcutaneous ratio (VSR). A genome-wide association study (GWAS) was completed using Illumina HumanHap 300 BeadChip (approximately...
OBJECTIVE The vascular ectonucleotidase ENTPD1 protects against renal injury and modulates glucose homeostasis in mouse models. We sought to determine whether human variation influences predisposition diabetes or diabetic nephropathy. RESEARCH DESIGN AND METHODS analyzed single nucleotide polymorphisms (SNPs) 363 African American control subjects, 380 subjects with type 2 end-stage disease (DM-ESRD), 326 ESRD unrelated (non–DM-ESRD). Using cell lines, we correlated disease-associated...
Abstract Obesity has been shown to increase risk for cardiovascular disease and type-2 diabetes. In addition, it implicated in aggravation of neurological conditions such as Alzheimer’s. the model organism Drosophila melanogaster, a physiological state mimicking diet-induced obesity can be induced by subjecting fruit flies solid medium disproportionately higher sugar than protein, or that supplemented with rich source saturated fat. These exhibit increased circulating glucose levels,...
The genome‐wide association study by Herbert et al. identified the INSIG2 single‐nucleotide polymorphism (SNP) rs7566605 as contributing to increased BMI in ethnically distinct cohorts. present sought further clarify matter, testing whether SNPs of influenced quantitative adiposity or glucose homeostasis traits Hispanics Insulin Resistance Atherosclerosis Family Study (IRASFS). Using a tagging SNP approach, and 31 additional were genotyped 1,425 IRASFS Hispanics. tested for with six...
Recently, a genome-wide association scan was completed in the IRAS (Insulin Resistance Atherosclerosis Study) Family Study (IRASFS) Hispanic-American cohort. Multiple single-nucleotide polymorphisms (SNPs) G-protein signaling 6 (RGS6) gene were found to be associated with adiposity phenotypes. RGS6 has shown downstream antagonistic interplay opioid receptors, targets of fatty/sugary food agonists. The possibility that promotes tolerance and tachyphylaxis among receptor is plausible pathway...
There is a connection between nutrient inputs, energy-sensing pathways, lifespan variation and aging. Despite the role of metabolic enzymes in energy homeostasis their metabolites as signals, little known about how gene expression impacts lifespan. In this report, we use P-element mutagenesis Drosophila to study effect on reductions seven central enzymes, contrast effects normal diet dietary restriction. The major observation that for five genes, reduction extends one or both diets. Two...
Genome-wide association studies (GWAS) have become beneficial in identifying genetic variants underlying susceptibility to various complex diseases and conditions, including obesity. Utilizing the Drosophila Genetic Reference Panel (DGRP), we performed a GWAS of lifespan 193 genetically distinct lines on high sugar diet (HSD). The DGRP analysis pipeline determined most significant associated polymorphisms were within loci genes involved in: neural processes, behavior, development, apoptosis,...