A5013299252- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Educational Innovations and Technology
- E-Learning and Knowledge Management
- Asymmetric Synthesis and Catalysis
- Liver Disease Diagnosis and Treatment
- Synthesis and Biological Evaluation
- Axial and Atropisomeric Chirality Synthesis
- Metal-Organic Frameworks: Synthesis and Applications
- Impact of Technology on Adolescents
- Plant and animal studies
- Chemical synthesis and alkaloids
- Synthesis and biological activity
- Educational Technology in Learning
- Neurobiology and Insect Physiology Research
- Problem and Project Based Learning
- Plant biochemistry and biosynthesis
- Click Chemistry and Applications
- Catalytic C–H Functionalization Methods
- Pharmacogenetics and Drug Metabolism
- Fluorine in Organic Chemistry
- Allelopathy and phytotoxic interactions
- thermodynamics and calorimetric analyses
Universidad de Sevilla
2015-2023
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2019-2021
École d'Ingénieurs en Chimie et Sciences du Numérique
2019-2021
Université Claude Bernard Lyon 1
2019-2021
Centre National de la Recherche Scientifique
2019-2021
A new type of chiral sulfinamide phosphinate catalysts with up to three stereogenic centers, readily accessible from commercially available starting materials, is reported. The naphthyl derivative SulPhos proved be highly efficient in the organocatalytic asymmetric imine reduction, leading a wide range arylmethylamines high yields 99% ee under 10% catalyst loading. synthetic utility this method was demonstrated by expeditious enantioselective synthesis calcimimetic NPS-R568.
Abstract An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin , has been developed for the enantioselective rhodium‐catalysed addition of aryl‐boronic acids to trifluoromethyl ketones. This shelf‐stable ligand is insensitive air, oxygen and moisture, it obtained in only two high yielding steps from cheap commercially available ( R )‐ tert ‐butanesulfinamide. The new tolerates use hindered boronic leads formation a series trifluoromethyl‐substituted tertiary carbinols yields...
The N‐alkylation of phenylacetamide with benzyl alcohol has been studied using Ni/SiO 2 –Al O 3 . In the optimized conditions, desired product was isolated in an excellent 98 % yield. reaction could advantageously be performed neat a slight excess amide and catalytic amount base. These conditions were tested on large range amides alcohols, affording 24 compounds 13 to 99 yields.
The synthetic method developed for the preparation of NH 2 /SO palladium complexes proved to be also an effective approach N -desulfinylation. Furthermore, Pd demonstrated a higher trans influence PhSO compared t BuSO.
Vector-borne diseases cause around 700,000 deaths every year. Insect repellents are one of the strategies to limit them. Para-menthane-3,8-diol (PMD), a natural compound, is most promising alternatives conventional synthetic repellents. This work describes diastereodivergent method synthesize each diastereoisomer PMD from enantiopure citronellal and studies their repellence activity against Aedes albopictus. We found that cis-PMD kinetic control product cyclization citronellal, while...
A new family of sulfinamide/sulfoxide derivatives was synthesized as chiral bidentate ligands by stereoselective additions methylsulfinyl carbanions to N-tert-butylsulfinylimines. The ligands, with C1, pseudo-meso, and pseudo-C2 symmetries, were successfully assayed in Rh-catalyzed arylboronic acids activated ketones. sterically dissymmetric C1 ligand (RS,SC,RS)-N-[1-(phenylsulfinyl)-3-methylbut-2-yl] tert-butylsulfinamide turned out be the optimal one, allowing 1,4-additions diverse acids,...
Abstract The reaction tolerates diverse arylmethyl imines while delivering the corresponding amines in high yields and with enantiomeric excesses.
B. BeginesV. ValdiviaE. BenitoR. RecioL. Romero-AzogilL.G. BorregoA. AlcudiaI. MolinaM. Vega-HolmE. Vengut-ClimentM. Bueno
E. BenitoR. RecioB. BeginesV. ValdiviaL.G. BorregoL. Romero-AzogilA. AlcudiaI. MolinaM. Vega-HolmE. Vengut-ClimentM. Bueno