A5068161609- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Mechanical Circulatory Support Devices
- Anesthesia and Neurotoxicity Research
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Central Venous Catheters and Hemodialysis
- Infectious Aortic and Vascular Conditions
- Antimicrobial Resistance in Staphylococcus
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Child Nutrition and Feeding Issues
- Antifungal resistance and susceptibility
- Cardiac and Coronary Surgery Techniques
- Fungal Infections and Studies
- Analytical Chemistry and Sensors
- Abdominal Surgery and Complications
- Aortic Disease and Treatment Approaches
- Teratomas and Epidermoid Cysts
- Clinical Nutrition and Gastroenterology
- Esophageal and GI Pathology
- Obstructive Sleep Apnea Research
- Head and Neck Anomalies
University of Michigan
2016-2022
University of Minnesota Medical Center
2022
University of Minnesota
2022
Vanderbilt University
2022
Beaumont Hospital, Royal Oak
2018-2020
Michigan Medicine
2018
Beaumont Health
2016
Wayne State University
2007
John D. Dingell VA Medical Center
2007
Nitric oxide (NO) has many important physiological functions, including its ability to inhibit platelet activation and serve as potent antimicrobial agent. The multiple roles of NO in vivo have led great interest the development biomaterials that can deliver for specific biomedical applications. Herein, we report a simple solvent impregnation technique incorporate nontoxic donor, S-nitroso-N-acetylpenicillamine (SNAP), into more biocompatible grade polymer, CarboSil 20 80A. resulting...
Blood-contacting devices, such as intravascular catheters, suffer from challenges related to thrombus formation and infection. Nitric oxide (NO) is an endogenous antiplatelet antimicrobial agent. Exogenous release of NO various polymer matrices has been shown reduce thrombosis infection of/on implantable medical devices. However, the clinical applications materials have hindered due factors donor leaching thermal instability. In this study, a novel approach demonstrated in which one lumen...
Cardiopulmonary bypass (CPB) causes a systemic inflammatory response syndrome (SIRS) associated with multiorgan injury. A model was developed to test whether blood-air interface (BAI) in the CPB circuit blood element activation and inflammation. Ten healthy swine were placed on partial for 2 hours via cervical vessels monitored 96 postoperatively. Five pigs (control group) had minimal air exposure circuit, while five exposed BAI simulating cardiotomy suction. There no significant differences...
In a rabbit model of cardiopulmonary bypass (CPB) and cardioplegic arrest, we previously showed that hyperoxic myocardial reperfusion was associated with increased left ventricular (LV) systolic dysfunction injury compared normoxic reperfusion. The aim this study to evaluate in our experimental the impact post-CPB conditions on other organs potentially vulnerable ischemic such as brain kidney.After 60 min CPB, aortic cross-clamp, cold rabbits were reperfused under or for 120 min. Left...
We are reporting a case of 12-year old African-American female who presented with six-month history painless, enlarging, midline neck mass. Imaging demonstrated 4-cm solid mass cystic components and calcifications. Differential diagnosis included dermoid tumor, teratoma, sarcomatous lesion, thyroglossal duct cyst carcinoma, ectopic thyroid tissue malignant transformation. Preoperative studies were unremarkable. Patient underwent Sistrunk procedure cervical lymph node dissection. Pathology...
Background: Nicorandil, an adenosine triphosphate-sensitive potassium channel agonist and nitric oxide donor, is a coronary vasodilator used to treat ischemia-induced chest pain, but it’s potential cardioprotective benefits during open heart surgery have not been thoroughly investigated. The study objective was assess the impact of nicorandil on postoperative ventricular dysfunction end-organ injury in established experimental model open-heart with cardiopulmonary bypass (CPB) cardioplegic...
Sternal infection after cardiac surgery is an infrequent post-operative complication. Aspergillus sternal osteomyelitis a rarity. We review the case of 77-year-old man with invasive aspergillosis sternum and left costal cartilage 23 years undergoing surgery. The patient promptly underwent surgical irrigation debridement, followed by antifungal therapy. Clinical suspicion fungal should be high in patients mediastinitis history Treatment prompt.
Background: Percutaneous endoscopic gastrostomy (PEG) is a preferred method of long-term enteral nutritional support. Despite its ease placement, it has 4% major complication rate, requiring surgical intervention or hospitalization. Early PEG tube dislodgment can cause peritonitis, emergent laparotomy at significant morbidity and cost. T-fasteners have been used as an adjunct gastropexy, but nearly one third migrate into the abdominal wall within first 2 weeks. We describe low-cost,...