A5055121992- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Air Quality and Health Impacts
- Adipokines, Inflammation, and Metabolic Diseases
- Global Cancer Incidence and Screening
- Diet, Metabolism, and Disease
- Cholesterol and Lipid Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Diabetes Management and Education
- Neonatal Health and Biochemistry
- Heavy Metal Exposure and Toxicity
- Cardiovascular Health and Risk Factors
- Health Promotion and Cardiovascular Prevention
- Cancer-related molecular mechanisms research
- Obesity, Physical Activity, Diet
- Lipoproteins and Cardiovascular Health
- High Altitude and Hypoxia
- Metabolism, Diabetes, and Cancer
- Cancer Risks and Factors
- Traditional Chinese Medicine Analysis
- Birth, Development, and Health
- Traditional Chinese Medicine Studies
Xinjiang Production and Construction Corps
2023-2025
Shihezi University
2016-2025
National Engineering Research Center of Human Stem Cells
2018-2025
Central South University
2024
Huazhong University of Science and Technology
2019-2023
Henan University
2018
Air Force Medical University
2017
Zhumadian Central Hospital
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
1990
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Accurately identifying subjects at high-risk CVD may improve outcomes. We sought to systematically examine feasibility and performance 7 widely used machine learning (ML) algorithms in predicting risks.The final analysis included 1508 Kazakh China without baseline who completed follow-up. All were randomly divided into training set (80%) test (20%). L1-penalized logistic regression (LR), support vector with radial...
Abstract Understanding the burden associated with occupational asbestos exposure on a global and regional scale is necessary to implement coordinated prevention control strategies. By GBD Study 2019, we conducted comprehensive assessment of non-communicable diseases attributable exposure. In 239,330 deaths 4,189,000 disability-adjusted life years (DALYs) worldwide due occurred. 1990–2019, DALYs attributed increased by 65.65% 43.66%, respectively. Age-standardized mortality rate (ASMR)...
Abstract Most previous studies on metabolic syndrome (MetS) examined urban and high income settings. We thus investigated the prevalence of MetS among a multi-ethnic population living in low rural area explored use visceral adiposity anthropometric indicators to identify men women with MetS. recruited 10,029 individuals nomadic Kazakhs, Uyghur Han residents Xinjiang, China. was defined by Joint Interim Statement criteria. The receiver operating characteristic curve (ROC) used compare under...
Arsenic produces liver disease through the oxidative stress. While lutein can alleviate cytotoxic and injury, nuclear factor erythroid 2-related 2 (Nrf2) pathway plays a critical role in defending species. However, mechanisms by which protects against effect of arsenic are not known. Therefore, this study aims to investigate involved action using mice model hepatotoxicity was induced arsenic. We found that treatment with could reverse changes morphological indexes result significant...
Cardiovascular diseases (CVD) are currently the leading cause of premature death worldwide. Model-based early detection high-risk populations for CVD is key to prevention. Thus, this research aimed use machine learning (ML) algorithms establish a prediction model based on routine physical examination indicators suitable Xinjiang rural population.The cohort data collection was divided into two stages. The first stage involved baseline survey from 2010 2012, with follow-up ending in December...
This study aimed to estimate the prevalence of diabetes mellitus (DM) and impaired fasting glucose (IFG) in a Kazakh population aged ≥18 years living YiLi District Xinjiang, China evaluate associated risk factors diabetes.Randomly selected adults, for at least 6 months Xinjiang had their clinical characteristics standard blood chemistries measured. DM IFG were defined according WHO 1999 criteria. The adjusted odds ratio (ORs) 95% confidence intervals calculated association multivariate...
Abstract Background Leukemia is a threat to human health, and there are relatively few studies on the incidence, mortality disease burden analysis of leukemia in China. This study aimed analyze incidence rates China from 2005 2017 estimate their age-period-cohort effects, it an important prerequisite for effective prevention control leukemia. Methods data were collected Chinese Cancer Registry Annual Report. Joinpoint regression model was used average annual percentage change (AAPC) (APC)...
Metabolic syndrome (MetS) has become a global public health problem affecting all nations and races. Few studies on the epidemic of metabolic examined multi-ethnic adults in rural areas Xinjiang, China. We thus investigated prevalence risk factors MetS there. A cross-sectional study was performed representative sample 15020 from 2009 to 2010. Four widely used criteria (ATPIII\IDF\JIS\CDS) were measure MetS. Multiple logistic regression analysis explore The age-adjusted 14.43%, 21.33%,...
Objective: To compare the screening ability of various anthropometric and atherogenic indices for Metabolic syndrome (MetS) using three common criteria to evaluate validity suitable parameters in combination MetS among a Kazakh population Xinjiang. Methods: A total 3752 individuals were selected stratified cluster random sampling method from nomadic Kazakhs (≥18 years old) Xinyuan county, Xinjiang, China, which is approximately 4407 km away capital Beijing. was defined by International...
ABSTRACT Titanium dioxide nanoparticles (TiO 2 NPs) can induce the cell cycle arrest in spermatogonia, and JAK2/STAT3 signaling pathway plays a pivotal role progression, but specific upstream regulatory mechanisms are not completely clarified. The purpose of this study was to investigate whether CXCL13 regulated participate after mouse spermatogonia line (GC‐1) exposure TiO NPs. GC‐1 cells were treated with NPs at different concentrations (0, 10, 20, 30, 40 μg/mL) for 24 h detect viability,...
Ischemic stroke, accounting for approximately 80% of all stroke cases, is a major public health challenge and leading cause death disability worldwide. Current treatments primarily involve thrombolytic therapy, limited to 4.5-hour window due the risk complications, underscoring need new therapeutic targets. Systemic inflammation plays critical role in progression, with immune cells infiltrating brain exacerbating damage. B cells, particular, have been implicated pathogenesis, although their...
Objective . To study the relationships between IR and glucose lipid metabolism in far western China these relationships’ ethnic heterogeneity. Methods From baseline survey, 419 Uygur cases, 331 Kazak 220 Han cases were randomly selected, resulting a total of 970 for study. FINS concentration was measured by radioimmunoassay. Results (1) In population, correlated with hyperglycemia; high levels TC, TG, LDL-C; low HDL-C abdominal obesity (all <mml:math...
The effects of lead as a dietary pollutant remain global public health concern that needs urgent resolution. Children are highly susceptible to the adverse outcomes pollution, even low levels may cause irreversible damage intellectual development. Since several sources exposure present in environment, it is necessary identify attributable burden lead-related diseases arising from different sources. In study, we used epidemiological data studies around nation estimate mild disability (MID)...
Abstract Background To externally validate the Prediction for ASCVD Risk in China (PAR) risk equation predicting 5-year atherosclerotic cardiovascular disease (ASCVD) Uyghur and Kazakh populations from rural areas northwestern compare its performance with those of pooled cohort equations (PCE) Framingham score (FRS). Methods The final analysis included 3347 subjects aged 40–74 years without CVD at baseline. was calculated using PAR, PCE, FRS. Discrimination, calibration, clinical usefulness...
Deoxynivalenol (DON), one of the most prevalent mycotoxins, has been found to cause fetal growth retardation in animals. However, limited evidence exists regarding its effects on pregnant women.Maternal urinary concentration total DON (tDON) and free (fDON) second trimester was measured using liquid chromatography with tandem mass spectrometry. Provisional daily intake (PDI) calculated based tDON concentration. Linear logistic regression models were used evaluate association between exposure...
The present network meta‑analysis aimed to compare the effectiveness and adverse effects of gefitinib, erlotinib icotinib in treatment patients with non‑small cell lung cancer (NSCLC). Two reviewers searched Cochrane, PubMed, Embase, ScienceDirect, China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals Wanfang databases relevant studies. Studies were then screened evaluated, data was extracted. End‑points evaluated NSCLC included complete response (CR),...
Metabolic syndrome (MS) and Framingham risk score (FRS) can be used for predicting the of developing cardiovascular diseases (CVD). Previous studies that compared FRS MS have focused on high-income urban areas. This study comparison between when in nomadic minorities mountain Moreover, an applicable tool CVD was identified. 2,286 participants who were recruited from far west China followed-up a median 5.49 years. terms their ability development using Cox regression receiver operating...