A5037300925- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diet, Metabolism, and Disease
- Trace Elements in Health
- Liver Disease and Transplantation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diet and metabolism studies
- Acute Kidney Injury Research
- Inflammasome and immune disorders
- Renal cell carcinoma treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Hedgehog Signaling Pathway Studies
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects and Toxicity Studies
- Inflammatory mediators and NSAID effects
- Ferroptosis and cancer prognosis
- Parkinson's Disease Mechanisms and Treatments
- NF-κB Signaling Pathways
- Occupational and environmental lung diseases
- Therapeutic Uses of Natural Elements
- Chemotherapy-induced cardiotoxicity and mitigation
- Peroxisome Proliferator-Activated Receptors
Mansoura University
2015-2025
This study investigates the effect of ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) on insulin resistance induced by high-fructose diet (HFD) in rats. Male Sprague Dawley rats were fed 60% HFD for 12 weeks and HMB (320 mg·kg(-1)·day(-1), orally) 4 weeks. significantly increased fasting insulin, glucose, glycosylated hemoglobin (HBA1C), liver glycogen content, homeostasis model assessment (HOMA-IR) index, while it decreased glucose tolerance. Furthermore, serum triglycerides (TG), low...
Breast cancer prevalence has been globally increasing, therefore, introducing novel interventions in treatment is of a significant importance. The present study was designed to investigate the anti-cancer effect Canagliflozin (CNG) an experimental model DMBA-induced mammary carcinoma female rats.18 rats were divided into three groups: Normal control, DMBA DMBA+ CNG treated group. (7.5 mg/kg) injected subcutaneously cells twice weekly for 4 weeks and (10 orally administered daily additional 3...
Abstract Liver fibrosis is a public health burden that highly associated with morbidity and mortality. Therefore, this study aims to explore the anti‐fibrotic effects of low dose paclitaxel (PTX) against thioacetamide (TAA)‐induced liver in rats possible mechanisms involved. TAA was administered at 200 mg/kg twice weekly for 6 weeks induce similar humans. dysfunction shown by increased alanine aminotransferase, aspartate alkaline phosphatase, γ‐glutamyl transferase, along histopathological...
There is a large body of evidence that nitric oxide (NO) formation implicated in mediating silica-induced pulmonary fibrosis. As reactive free radical, NO may not only contribute to lung parenchymal tissue injury but also has the ability combine with superoxide and form highly toxic species peroxynitrite can induce extensive cellular toxicity tissues. This study aimed explore effect agmatine, known synthase inhibitor, on fibrosis rats. Male Sprague Dawley rats were treated agmatine for 60...
Abstract Acetaminophen (APAP) overdose can produce hepatotoxicity and consequently liver damage. This study investigated the hepatoprotective impacts of nicorandil on hepatic damage induced by APAP. Nicorandil was administered orally (100 mg/kg) for seven days before APAP challenge (500 mg/kg, ip). Pretreatment with reduced serum levels aminotransferases, bilirubin, GGT LDH, increased level albumin. Moreover, inhibited increase in MDA reversed decline GSH content SOD activity. Besides, it...