A5015126277- Immune Response and Inflammation
- Immune Cell Function and Interaction
- interferon and immune responses
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Human-Automation Interaction and Safety
- Birth, Development, and Health
- Cell death mechanisms and regulation
- Protein Tyrosine Phosphatases
- Older Adults Driving Studies
- Abdominal vascular conditions and treatments
- NF-κB Signaling Pathways
- Traffic and Road Safety
Kitasato University
2024
RIKEN Center for Integrative Medical Sciences
2007-2023
Kagawa University
2011
Nagoya University
2007
Japan Society for the Promotion of Science
2007
Abstract Toll-like receptors recognize pathogen-associated molecular patterns, activate innate immunity, and consequently modulate adaptive immunity in response to infections. TLRs are also expressed on T cells, it has been shown that cell activation is modulated by TLR ligands. However, the functions of Th1 Th2 effector cells mechanisms underlying TLR-mediated not fully understood. We analyzed downstream signaling events both cells. In mouse stimulation TLR2 but other directly induced IFN-γ...
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation. Here, we show that T cell-specific RIPK1 deficiency in mice leads to the premature senescence of cells induces various age-related diseases, resulting death. causes higher basal activation mTORC1 (mechanistic target rapamycin complex 1) drives enhanced cytokine production, induction senescence-related genes, increased caspase-3/7, which are restored by inhibition mTORC1. Critically, normal aged exhibit...
Stimulator of interferon genes (STING) plays a key role in detecting cytosolic DNA and induces type I (IFN-I) responses for host defense against pathogens. Although T cells highly express STING, its physiological remains unknown. Here, we show that costimulation with the STING ligand cGAMP TCR leads to IFN-I production strongly inhibits T-cell growth. TCR-mediated mTORC1 activation sustained IRF3 are required cGAMP-induced production, activity is partially counteracted by cGAMP, thereby...
Effector, but not naïve, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. We found that the differential response is attributable lack of expression adaptor protein TIRAP in naive cells. induced upon T-cell receptor (TCR) stimulation sustained strong interleukin-2 (IL-2) signals. Expression requires TCR- IL-2-induced mTORC1 activation. TLR2 activation nuclear factor κB (NF-κB) ERK, much higher interferon-γ (IFN-γ) helper 1...