A5054281465- Photonic and Optical Devices
- Metamaterials and Metasurfaces Applications
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Thermal Radiation and Cooling Technologies
- Optical Coatings and Gratings
- Mesenchymal stem cell research
- Liver Disease and Transplantation
- Photonic Crystals and Applications
- RNA modifications and cancer
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- Eosinophilic Esophagitis
- Nutritional Studies and Diet
- Helicobacter pylori-related gastroenterology studies
- Organ Transplantation Techniques and Outcomes
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- melanin and skin pigmentation
- Advanced Materials and Mechanics
- TGF-β signaling in diseases
Air Force General Hospital PLA
2023-2025
University of Washington
2020-2025
Air Force Medical University
2014-2025
Xijing Hospital
2014-2025
National Clinical Research Center for Digestive Diseases
2018-2025
Zhejiang Gongshang University
2025
Hubei University of Chinese Medicine
2024
META Health
2024
Seattle University
2022
National Clinical Research
2021
Abstract Subwavelength diffractive optics known as meta-optics have demonstrated the potential to significantly miniaturize imaging systems. However, despite impressive demonstrations, most meta-optical systems suffer from strong chromatic aberrations, limiting their utilities. Here, we employ inverse-design create broadband operating in long-wave infrared (LWIR) regime (8-12 μ m). Via a deep-learning assisted multi-scale differentiable framework that links meta-atoms phase, maximize...
Hypoxia induced drug resistance is a major obstacle in the development of effective cancer therapy. Our previous study revealed that hypoxia‐inducible factor‐1 (HIF‐1), transcriptional factor significantly activated by hypoxia, was overexpressed gastric vincristine‐resistant cells SGC7901/vincristine (VCR) under normoxic conditions, which suggested it associated with cells. In present study, colony‐forming assay hypoxia and forced HIF‐1α expression increased maximal –8.9‐fold or –14.8‐fold...
Miniature lenses with tunable focus are essential components for many modern applications involving compact optical systems. While several have been reported various tuning mechanisms, they often still face challenges in power consumption, speed, fabrication cost, or production scalability. In this work, we adapted the mechanism of an Alvarez lens - a varifocal composite which lateral shifts two elements cubic phase surfaces give rise to change construct miniature, MEMS-actuated metasurface...
Squamous cell carcinomas (SCCs) originate in stratified epithelia, with a small subset becoming metastatic. Epithelial stem cells are targets for driver mutations that give rise to SCCs, but it is unknown whether they contribute oncogenic multipotency and metastasis. We developed mouse model of SCC by targeting two frequent genetic human oncogene Kras(G12D) activation Smad4 deletion, keratin 15-expressing (K15+) cells. show transgenic mice multilineage tumors, including metastatic SCCs....
Mesenchymal stem cells (MSCs) and hematopoietic (HSCs) have been studied for damaged liver repair; however, the conclusions drawn regarding their homing capacity to injured are conflicting. Besides, relative utility synergistic effects of these two cell types on remain unclear.MSCs, HSCs combination both were obtained from bone marrow male mice expressing enhanced green fluorescent protein(EGFP)and injected into female with or without fibrosis. The distribution cells, survival rates,...
Flat optics have been proposed as an attractive approach for the implementation of new imaging and sensing modalities to replace augment refractive optics. However, chromatic aberrations impose fundamental limitations on diffractive flat As such, true broadband high-quality has thus far out reach low f-number, large aperture, In this work, we overcome these intrinsic limitations, achieving in visible wavelength range with a meta-optic, co-designed computational reconstruction. We derive...
Background Serum vitamin D levels are associated with bone complications in patients primary biliary cirrhosis (PBC). Increasing evidence suggests a nonskeletal role of various autoimmune and liver diseases. Aim To investigate the clinical relevance PBC, especially their association therapeutic effects ursodeoxycholic acid (UDCA). Methods Consecutive PBC were retrospectively reviewed. 25-hydroxyvitamin [25(OH)D] determined frozen serum samples collected before initiation UDCA treatment....
Autoimmune diseases are increasingly linked to aberrant gut microbiome and relevant metabolites. However, the association between vitiligo remains be elucidated. Thus, we conducted a case-control study through 16S rRNA sequencing serum untargeted-metabolomic profiling based on 30 patients matched healthy controls. In patients, microbial composition was distinct from that of controls according analysis α- β-diversity ( P < 0.05), with characteristic decreased Bacteroidetes: Firmicutes...
Foveated imaging provides a better tradeoff between situational awareness (field of view) and resolution, is critical in long wavelength infrared regimes because the size, weight, power, cost thermal sensors. We demonstrate computational foveated by exploiting ability meta-optical frontend to discriminate different polarization states backend reconstruct captured image/video. The three-element optic: first element, which we call “foveal” metalens that focuses s-polarized light at distance f...
Generating functional hepatocyte-like cells (HLCs) from mesenchymal stem (MSCs) is of great urgency for bio-artificial liver support system (BALSS). Previously, we obtained HLCs human umbilical cord-derived MSCs by overexpressing seven microRNAs (HLC-7) and characterized their functions in vitro vivo. Here, aimed to screen out the optimal miRNA candidates hepatic differentiation. We sequentially removed individual miRNAs pool examined effect transfection with remainder using RT-PCR, periodic...
Further miniaturization of imaging systems is prevented by the prevalent, traditional bulky refractive optics today. Meta-optics have recently generated great interest in visible wavelength as a replacement for thanks to their low weight, small size, and amenability high-throughput semiconductor manufacturing. Here, we extend these meta-optics long-wave infrared (LWIR) regime demonstrate with 2 cm aperture f /1 all-silicon metalens under ambient thermal emission. We showed that even strongly...
BACKGROUND Bleeding ectopic varices located in the small bowel (BEV-SB) caused by portal hypertension (PH) are rare and life-threatening clinical scenarios. The current management of BEV-SB is unsatisfactory. This retrospective study analyzed four cases PH detailed these using enteroscopic injection sclerotherapy (EIS) subsequent interventional radiology (IR). AIM To analyze develop a treatment algorithm. METHODS was single tertiary care center before-after study, including patients...
<title>Abstract</title> Background Stigma is common in certain infectious diseases and infection-related cancer. Helicobacter pylori (H. pylori) related to gastric However, little known about the relationship between H. infection stigma. Therefore, our study aims investigate stigma its influencing factors among patients with infection. Materials Methods 1144 participants were recruited from a tertiary hospital northwest China October 2023 July 2024. The research instruments comprised Social...
Flat optics have been proposed as an attractive approach for the implementation of new imaging and sensing modalities to replace augment refractive optics. However, chromatic aberrations impose fundamental limitations on diffractive flat As such, true broadband high-quality has thus far out reach fast f-numbers, large aperture, In this work, we overcome intrinsic spectral bandwidth limitations, achieving in visible wavelength range with a meta-optic, co-designed computational reconstruction....
ABSTRACT The GitHub issue community serves as the primary means for project developers to obtain information about program bugs, and numerous users post issues based on encountered vulnerabilities or error messages. However, these often vary in quality, leading a significant time burden developers. By collecting 2500 bug‐related from five projects, we first manually analyze large volume of formulate rules identifying whether bug‐tagged is truly fixed by We find that substantial number...
This study aimed to assess the association of past obesity and BMI trajectories with cancer mortality in National Health Nutrition Examination Survey. Past was identified based on maximum body weight, change were determined by latent class trajectory modeling (LCTM). Cox regression used mortality. A total 4,058 patients participated this study, which 46.3% obesity, resulting a significantly lower risk compared participants who not (HR = 0.92, 95% CI: 0.92-0.93, P < 0.01). The LCTM five BMI,...
Voltage-gated potassium (Kv) channels have been reported to be involved in the proliferation of many types cells, including tumor cells. The overexpression Kv and related channel activity are neoplastic process. Our previous study has shown existence delayed rectifier (IK) current gastric cancer cells SGC7901. However, expression function most (KD) subunits not completely resolved. Here we examine KD Kv1-Kv3 families immortalized epithelial GES various (including AGS, KATO¢Û, MKN28, MKN45,...
Despite the extensive hepatic differentiation potential of human umbilical cord lining-derived mesenchymal stem cells (hUC-MSC), little is known about molecular mechanisms hUC-MSC differentiation. At post-transcriptional level, microRNAs are key players in control cell fate determination during In this study, we aimed to identify involved hUC-MSCs. After successfully isolating hUC- MSCs, induced hepatocyte formation vitro with growth factors. 26 days induction, hUC-MSCs could express...