A5072450044- Pluripotent Stem Cells Research
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune cells in cancer
- Renal and related cancers
- Developmental Biology and Gene Regulation
- Carbon and Quantum Dots Applications
- Luminescence Properties of Advanced Materials
- Reproductive System and Pregnancy
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Crystal Structures and Properties
- 2D Materials and Applications
- Animal Genetics and Reproduction
Institute for Systems Biology
2024
Tel Aviv University
2015-2021
Hinge Health
2021
Islamic Azad University North Tehran Branch
2012
Abstract The loss of the tail is among most notable anatomical changes to have occurred along evolutionary lineage leading humans and ‘anthropomorphous apes’ 1–3 , with a proposed role in contributing human bipedalism 4–6 . Yet, genetic mechanism that facilitated tail-loss evolution hominoids remains unknown. Here we present evidence an individual insertion Alu element genome hominoid ancestor may contributed evolution. We demonstrate this element—inserted into intron TBXT gene 7–9 —pairs...
Abstract Advancements in rational drug design over the past decades have consistently produced new cancer therapies, but such treatments are inevitably countered through an adaptive process that fosters therapy resistance. Malignant cells achieve resistance intrinsic and acquired mechanisms, rooted genetic non-genetic determinants. In particular, recent work has highlighted role of cellular heterogeneity emergence transient drug-tolerant persister survive treatment, as well non-genetically...
During early embryogenesis, mechanical constraints and localized biochemical signals co-occur around anteroposterior axis determination symmetry breaking. Their relative roles, however, are hard to tease apart in vivo. Using Brachyury (Bra), a primitive streak mesendoderm marker EBs, we study how contact, neighboring cell cues affect the positioning of streak-like locus, determining AP axis. We show that Bra-competent layer must be formed EB before Bra expression initiates, onset locus...
The loss of the tail is one main anatomical evolutionary changes to have occurred along lineage leading humans and “anthropomorphous apes” 1,2 . This morphological reprogramming in ancestral hominoids has been long considered accommodated a characteristic style locomotion contributed evolution bipedalism 3–5 Yet, precise genetic mechanism that facilitated tail-loss remains unknown. Primate genome sequencing projects made possible identification causal links between genotypic phenotypic 6–8 ,...
Phenotypic heterogeneity within malignant cells of a tumor is emerging as key property tumorigenesis. Recent work using single-cell transcriptomics has led to the identification distinct cancer cell states across range types, but their functional relevance and advantage that they provide system remain elusive. We present here definition in terms coherently differentially expressed gene modules review origins, dynamics, impact on whole. The spectrum taken by population may depend cellular...
Multifunctional nanoparticles have attracted significant interest as biomedical vehicles, combining diagnostic, imaging, and therapeutic properties. We describe herein the construction of new nanoparticle conjugates comprising WS2 nanorods (NRs) coupled to fluorescent carbon dots (C-dots). show that -C-dot hybrids integrate unique physical properties two species, specifically photothermal activity NRs upon irradiation with near-infrared (NIR) light excitation-dependent luminescence emission...
The segregation of definitive endoderm (DE) from bipotent mesendoderm progenitors leads to the formation two distinct germ layers. Dissecting DE commitment and onset has been challenging as it occurs within a narrow spatiotemporal window in embryo. Here, we employ dual Bra/Sox17 reporter cell line study dynamics. We find Sox17 expression initiates vivo isolated cells temporally restricted window. In 2D 3D vitro models, emerge at regular, but spatially stochastic pattern, which is...
Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS 2 ) nanotubes and nanoparticles are among most extensively studied members this group, used for, e.g., polymer reinforcement, lubrication electronic devices. Their biocompatibility low toxicity make them suitable for medical biological applications. One potential application is photothermal therapy (PTT), a method targeted treatment cancer, which...
The aim of the present study was to prepare nano-sized calcium fluoride (CaF2). Calcium nanoparticles were synthesized by CaCl2.6H2O and ammonium fluoride. Nanoparticles co-precipitation method. nanocrystals characterized X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM). crystallite size estimated using Scherer’s formula found be in range 20–30nm for this morphological features as studied SEM revealed that agglomerated, crispy with porous.
Abstract The segregation of definitive endoderm (DE) from mesendoderm progenitors leads to the formation two distinct germ layers. Dissecting DE onset has been challenging as it occurs within a narrow spatio-temporal window in embryo. Here we employ dual Bra-GFP, Sox17-RFP reporter cell line study dynamics. We find Sox17 starts few isolated cells vivo . Using 2D and 3D vitro models, show that emerge at temporally regular, but spatially stochastic pattern, which is subsequently arranged by...
Abstract During early embryogenesis, mechanical signals, localized biochemical signals and neighboring cell layers interaction coordinate around anteroposterior axis determination symmetry breaking. Deciphering their relative roles, which are hard to tease apart in vivo, will enhance our understanding of how these processes driven. In recent years, vitro 3D models mammalian development, such as embryoid bodies (EBs) gastruloids, were successful mimicking various aspects the embryo, providing...
ABSTRACT While genetic tumor heterogeneity has long been recognized, recent work revealed significant variation among cancer cells at the epigenetic and transcriptional levels. Profiling tumors single-cell level in individual types shown that is organized into cell states, implying diverse states may represent stable functional units with complementary roles maintenance progression. However, it remains unclear to what extent these span types, constituting general features of cancer....
The segregation of definitive endoderm (DE) from bi-potent mesendoderm progenitors leads to the formation two distinct germ layers. Dissecting DE commitment and onset has been challenging as it occurs within a narrow spatio-temporal window in embryo. Here we employ novel dual Bra/Sox17 reporter cell line study dynamics. We find Sox17 expression initiates few isolated cells vivo temporally restricted window. Using 2D 3D vitro models, show that emerge at regular, but spatially stochastic...
Abstract The loss of the tail is one main anatomical evolutionary changes to have occurred along lineage leading humans and “anthropomorphous apes” 1,2 . This morphological reprogramming in ancestral hominoids has been long considered accommodated a characteristic style locomotion contributed evolution bipedalism 3–5 Yet, precise genetic mechanism that facilitated tail-loss remains unknown. Primate genome sequencing projects made possible identification causal links between genotypic...