A5019046752- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Cystic Fibrosis Research Advances
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Research and Treatments
- Pediatric health and respiratory diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Neonatal Respiratory Health Research
- Acute Ischemic Stroke Management
- Pluripotent Stem Cells Research
- Neurosurgical Procedures and Complications
- Nosocomial Infections in ICU
- Metabolism and Genetic Disorders
- Cardiac Arrest and Resuscitation
- Inhalation and Respiratory Drug Delivery
- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Coronary Interventions and Diagnostics
- Potassium and Related Disorders
- Phonocardiography and Auscultation Techniques
- Amyotrophic Lateral Sclerosis Research
Beijing Normal University
2025
Peking University
2014-2025
Peking University Third Hospital
2014-2025
Yangtze University
2025
Linyi People's Hospital
2024
Weifang People's Hospital
2024
Suzhou Institute of Nano-tech and Nano-bionics
2024
Chinese Academy of Sciences
2024
Yunnan Population and Family Planning Research Institute
2023
Second Hospital of Liaohe Oilfield
2014
Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients "early" stage mild acute respiratory distress syndrome (ARDS, PaO2/FIO2 between 200 and 300). To evaluate whether early NIV can reduce invasive in pneumonia-induced ARDS. Prospective, multicenter, randomized controlled trial (RCT) through a Venturi mask. Primary outcome included numbers who met criteria. Two hundred subjects were to (n =...
Abstract Background While the prevalence and disease burden of bronchiectasis are increasing, data in world’s largest population lacking. We aimed to investigate Chinese adults. Methods conducted a population-based study using between 2013 2017 from national databases Urban Employee Basic Medical Insurance Resident China. Data over 380 million patients aged 18 years older during period were analyzed, total 383,926 identified. Primary outcomes included age- sex-specific bronchiectasis. Annual...
The combination of extreme formation pressure, significant burial depth, and dense lithology in deep ultra-deep reservoirs results abnormal fracturing pressure behavior. This phenomenon elevates operational pressures during acidizing treatments while amplifying associated engineering risks. Precise prediction both reservoir pump injection has become imperative under current technological constraints to ensure safety successful stimulation. study establishes a comprehensive framework through:...
Purpose: Patients with chronic obstructive pulmonary disease (COPD) would have a poor prognosis if they were not continuously managed according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. We aim develop model classify whether COPD patients been GOLD in previous year. Methods: The Managed group from prospective cohort November 2017 2019, who 1 Control GOLD. They retrospective October 2016 same hospitals as group. A synthetic minority over-sampling...
Complex biological mechanisms and unidentified therapeutic targets for amyotrophic lateral sclerosis (ALS) significantly hinder the development of effective treatments. Given these challenges, reliable disease models that accurately replicate ALS phenotypes with relevant underpinnings are essential advancing precision medicine in ALS. Patient-derived induced pluripotent stem cell (iPSC) organoids have emerged as an innovative tool modeling drug evaluation. Growing evidence highlights...
Viral infections constitute a primary trigger for asthma exacerbations. While vaccines protect against viral by eliciting Th1 immune response, the impact of asthmatic milieu which is characterized Th2 cytokine dominance and elevated IgE levels on post-vaccination antibody production remains elusive. Therefore, vaccination protocols tailored to patients need be formulated. The IgG specific SARS-CoV-2 S protein were measured in sera vaccinated unvaccinated individuals ELISA. differences titers...
Purpose: To investigate how the changes of definition in assessment Global Initiative for Chronic Obstructive Lung Disease (GOLD) stratification 2017 lead to chronic obstructive pulmonary disease (COPD) patient clinical characteristics across categories China. Patients and methods: COPD patients from 11 medical centers China were stratified into old new groups A–D twice according GOLD 2011 comprehensive assessment. Demography compared between A–D. Results: In 1,532 patients, distribution...
Abstract Background Chronic obstructive pulmonary disease (COPD) is one of the most prevalent diseases worldwide. Episodes acute exacerbations COPD (AECOPD) are associated with severity and progression. Although substantial progress has been made in understanding dynamics AECOPD, little known about sputum microbiome AECOPD Chinese population. Methods In this study, we characterized microbiomes from specimens collected healthy controls ( n = 10), stable 4), 36), recovery 18) stages by...
Our study aimed to investigate whether serum total IgE and blood eosinophils were associated with radiological features of bronchiectasis in a Chinese cohort.We retrospectively enrolled patients who visited Peking University Third Hospital from Jan 1st, 2012 Oct 7th, 2021. The clinical, laboratory chest CT characteristics analyzed association level eosinophil count.A 125 enrolled, 50.4% (63/125) female, mean age 62.4 ± 14.1 years. median count 47.7 (19.8, 123.0) KU/L 140 (90, 230) cells/µl,...
Abstract Sphingolipids metabolism is an important cell process and plays critical roles in asthma. However, the involvement of sphingolipids pathogenesis asthma its subtypes unknown. The present study aimed to determine role subtypes. Clinical data from 51 patients 9 healthy individuals were collected serum samples performed analyze levels by liquid chromatography-mass spectrometry-based targeted metabolomics. Results showed that sphingomyelin (SM) including SM34:2, SM38:1, SM40:1...
The airway microbiota plays an important role in asthma pathophysiology. However, the relationship between and phenotypes is still poorly understood.We aimed to characterize patients determine its correlation with inflammatory other phenotypic characteristics.The microbial composition of induced sputum specimens collected from was determined using 16S rDNA gene sequencing.Patients had a higher abundance bacterial taxa associated Bacteroidetes, Fusobacteria Proteobacteria reduced Firmicutes...
Aetiology detection is crucial in the diagnosis and treatment of ventilator-associated pneumonia (VAP). However, method needs improvement. In this study, we used Nanopore sequencing to build a quick protocol compared efficiency different methods for detecting 7 VAP pathogens.The endotracheal aspirate (ETA) 83 patients with suspected from Peking University Third Hospital (PUTH) was collected, saponins were deplete host genomes, PCR- or non-PCR-amplified library construction compared. Sequence...
Background. Limited data are available about the clinical outcomes of AECOPD patients with respiratory acidosis treated HFNC versus NIV. Methods. We conducted a retrospective study to compare efficacy NIV as initial ventilation support strategy in acidosis. Propensity score matching (PSM) was implemented increase between-group comparability. Kaplan–Meier analysis utilized evaluate differences between success, failure, and groups. Univariate performed identify features that differed...
Both patients and physicians may be hesitant toward vaccination in with asthma, which result lower vaccine uptake. The aim of this work was to investigate the rate, adverse reactions, as well factors associated acceptance hesitancy COVID-19 among asthmatic Beijing.
Background The potential impact of elevated intra-abdominal pressure (IAP) on residual renal function (RRF) has not been determined. objective this study was to investigate the relationship between IAP and rate RRF decline in newly initiated peritoneal dialysis (PD) patients, identify optimal threshold value for delaying deterioration RRF.
Abstract: Tracheobronchial amyloidosis is a rare disease characterized by amyloid deposits on the tracheal and bronchial tissue. Patients with tracheobronchial are asymptomatic or exhibit symptoms, such as chronic wheezing, dyspnea, cough, that common manifestations of other disorders, including asthma. A bronchoscopic tissue biopsy using Congo red staining key standard for diagnosing amyloidosis. Treatment strategies vary depending degree airway obstruction. If obstruction significant...
A study was conducted on rural women of childbearing age aged 20-49 who underwent the National Free Preconception Health Examination Project (NFPHEP)in Yunnan Province from 2013 to 2019. Descriptive analysis determine negative rate IgG antibodies against rubella virus and its differences among various socio-demographic characteristics. Among 1 511 203 subjects, 24.36%. Only 2.64% population had received vaccine. The childbearing-age in preconception period decreased with educational level (
The impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on patients with bronchiectasis in terms symptoms, self-management and medical resource utilization was unknown.