A5101946860- DNA Repair Mechanisms
- RNA modifications and cancer
- Anaerobic Digestion and Biogas Production
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biofuel production and bioconversion
- Cancer therapeutics and mechanisms
- Catalysts for Methane Reforming
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Microbial Fuel Cells and Bioremediation
- Thermochemical Biomass Conversion Processes
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Wastewater Treatment and Nitrogen Removal
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Drug-Induced Hepatotoxicity and Protection
- Geothermal Energy Systems and Applications
- Chemical Looping and Thermochemical Processes
- Environmental remediation with nanomaterials
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Salivary Gland Disorders and Functions
- Agricultural Engineering and Mechanization
Henan Agricultural University
2015-2024
Ministry of Agriculture and Rural Affairs
2021-2024
Guizhou Provincial People's Hospital
2018-2024
Huizhou Central People's Hospital
2022
Center for Human Reproduction
2020
Shanghai Sixth People's Hospital
2018-2019
Shanghai Jiao Tong University
2010-2019
Xinjiang Medical University
2019
First Affiliated Hospital of Jinan University
2017
Tianjin University
2017
AIM:To evaluate the effects of positive regulation recombinant human interleukin 1 receptor antagonist (rhIL-1Ra) on hepatic tissue recovery in acute liver injury mice induced by carbon tetrachloride (CCl4). METHODS:Acute damage was injecting 8-wk-old with CCl4 mL/kg (1:3 dilution corn oil) intraperitoneally (ip).Survival after failure assessed a lethal dose 2.6 (1:1 ip.Mice
Tumor cells progressively remodel cytoskeletal structures and reduce cellular stiffness during tumor progression, implicating the correlation between cell mechanics malignancy. However, roles of cytoskeleton in progression remain incompletely understood. We report that softening/stiffening by targeting actomyosin promotes/suppresses self-renewal vitro tumorigenic potential vivo. Weakening/strengthening actin impairs/reinforces interaction adenomatous polyposis coli (APC) β-catenin, which...
Buckwheat is a globally recognized, nutritionally rich crop with robust adaptability, serving as multi-purpose plant for its health benefits. Achieving precise and mechanized plot seed harvesting critical step in obtaining accurate results breeding experiments. However, requires no retention, mixing, ensures accumulation of the threshing unit. A self-cleaning technology was developed to prevent multistage tangential cylinder The newly designed cleaning system has five air inlets centrifugal...
Hepatitis B virus (HBV) X protein (HBx) contributes to hepatocarcinogenesis. The overexpression of transcripts from P3 and P4 promoters the insulin-like growth factor 2 (IGF2) gene is observed in hepatocellular carcinoma (HCC). Here, we aimed explore involvement HBx P3-driven mRNA underlying epigenetic mechanism.P3 mRNA, methylation status, were analysed human HCC samples with without HBV infection using quantitative RT-PCR, bisulphite sequencing Western blotting. effects on expression,...
Sulfonamide antibiotics in the environment not only disrupt ecological balance but can also enter human or animal body various forms and cause harm. Therefore, exploring efficient methods to degrade sulfonamide is crucial. In this study, we prepared biochar (BC) using corn straw, TiO2/BC was obtained by doping different proportions of TiO2 into with varying carbonization temperatures sol-gel method. Next, investigated degradation sulfamethoxazole (SMX) solution generated under ultraviolet...
Abstract Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for pain relief clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis many cell types. However, the anti‐tumour mechanism of still poorly understood. In present study, we survey whether how aerobic colon cells. Glycolysis cells was determined by detecting extracellular acidification rate HT29 SW480 Quantitative real‐time PCR employed to determine mRNA expression....
Abstract Background Disease classification has been an important application of microarray technology. However, most microarray-based classifiers can only handle data generated within the same study, since by different laboratories or with platforms not be compared directly due to systematic variations. This issue severely limited practical use disease classification. Results In this we tested feasibility integrating large amount heterogeneous datasets from public repositories....
The human insulin-like growth factor-II (IGF-II) gene transcribes four mRNAs (P1 mRNA-P4 mRNA), and P3 mRNA overexpression contributes to hepatocarcinogenesis. IGF-II-derived miR-483-5p is implicated in the development of cancers. Here, we investigated involvement regulation its role hepatocellular carcinoma. Our results showed that up-regulated transcription by targeting 5'-untranslated region (5'UTR) mechanism was involved recruiting an argonaute 1(Ago1)-argonaute 2 (Ago2) complex 5'UTR...
Abstract Purpose Currently, the routine screening program has insufficient capacity for early diagnosis of lung cancer. Therefore, a type chitosan-molecular beacon (CS-MB) probe was developed to recognize miR-155-5p and image cancer cells diagnosis. Methods Based on molecular (MB) technology nanotechnology, CS-MB synthesized self-assembly. There are four types cells—three kinds animal models one histopathological sections human were utilized as models, including A549, SPC-A1, H446 cells,...
The aim of this study was to evaluate the feasibility measuring ALK gene rearrangement in cell-free RNA (cf-RNA) supernatant from malignant pleural effusion (MPE). Supernatant, cell blocks, and matched sera samples were collected. Cf-RNA isolated sera, cellular blocks. cf-RNA tested by real-time polymerase chain reaction. Results showed that concentration higher than sera. status concordance rates 100% between while they 0% blocks cases. This suggests using MPE supernatant, but not could...
ObjectiveTo investigate the effect of casein kinase 2 interacting protein 1 (CKIP-1) on apoptosis intestinal type gastric cancer (GC).MethodsThe levels CKIP-1 and rates were measured in tissue samples GC human cell lines. The rate B lymphoma-2 (Bcl-2), Bcl-2 associated X (Bax), cleaved cysteinyl aspartate specific protease 3 (cleaved caspase-3), caspase-9, rat sarcoma (Ras), extracellular signal-regulated (ERK1/2) phosphorylated (p-ERK1/2) analysed SGC7901 cells expressing short hairpin RNA...
Abstract Background Gastric cancer (GC) is one of the most common malignancies, and intestinal-type GC main histopathologic type in China. We previously reported that casein kinase 2 interacting protein 1 (CKIP-1) acts as a candidate tumor suppressor GC. CKIP-1 participates regulation multiple signaling pathways, including Wnt/β-catenin pathway, which caudal-related homeobox (CDX1) may be downstream target gene. The purpose this study was to investigate relationship between CDX1 Methods...
EGFR ‐activating mutations have been recognized as the most important predictor of response to EGFR‐tyrosine kinase inhibitors (TKIs); however, 20–30% patients harboring show poor responses. The mechanisms such EGFR‐TKI primary resistance are still poorly understood. In our case, a non‐small cell lung cancer patient developed intrinsic and was then confirmed simultaneously harbor an L858R mutation ROS1 rearrangement. Salvage chemotherapy plus Endostar showed enduring therapeutic effects,...