A5044365346- Catalytic Cross-Coupling Reactions
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Organoboron and organosilicon chemistry
- Crystallization and Solubility Studies
- CO2 Reduction Techniques and Catalysts
- Oxidative Organic Chemistry Reactions
- Electrochemical Analysis and Applications
- Coordination Chemistry and Organometallics
- Advanced Photocatalysis Techniques
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Chemical Synthesis and Reactions
- Electrocatalysts for Energy Conversion
- Asymmetric Hydrogenation and Catalysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Inorganic Fluorides and Related Compounds
- Cyclopropane Reaction Mechanisms
- Advanced Chemical Sensor Technologies
- Machine Learning in Materials Science
- Copper-based nanomaterials and applications
- Synthesis and Catalytic Reactions
University of Bristol
2012-2025
Salisbury University
2020
Korea University
2020
Pohang University of Science and Technology
2020
University of Ferrara
2020
Chiba University
2020
Tokyo University of Pharmacy and Life Sciences
2020
University of Wisconsin–Madison
2016-2018
Madison Group (United States)
2017
University of Rostock
2015-2016
The activity of plasmonic Au–TiO2 catalysts for solar hydrogen production from H2O/MeOH mixtures was found to depend strongly on the support phase (anatase, rutile, brookite, or composites thereof) as well specific structural properties caused by method Au deposition (sol-immobilization, photodeposition, deposition–precipitation). Structural and electronic rationale have been identified this behavior. Using a combination spectroscopic in situ techniques (EPR, XANES, UV–vis spectroscopy),...
Ruthenium PNP complex 1a (RuH(CO)Cl(HN(C2H4Pi-Pr2)2)) represents a state-of-the-art catalyst for low-temperature (<100 °C) aqueous methanol dehydrogenation to H2 and CO2. Herein, we describe an investigation that combines experiment, spectroscopy, theory provide mechanistic rationale this process. During catalysis, the presence of two anionic resting states was revealed, Ru–dihydride (3–) Ru–monohydride (4–) are deprotonated at nitrogen in pincer ligand backbone. DFT calculations showed O-...
Undercover agents: The biaryl coupling of an aryltrifluoroborate with aryl bromide involves in situ hydrolysis the boron reagent. products are key components ensuring that reaction proceeds high efficiency and avoids extensive generation undesired phenolic homocoupling side products. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note:...
The hydrolysis of potassium organotrifluoroborate (RBF3K) reagents to the corresponding boronic acids (RB(OH)2) has been studied in context their application Suzuki–Miyaura coupling. "slow release" strategy such SM couplings is only viable if there an appropriate gearing rate RBF3K reagent with catalytic turnover. In cases, acid RB(OH)2 does not substantially accumulate, thereby minimizing side reactions as oxidative homocoupling and protodeboronation. study reveals that rates (THF, H2O,...
Secondary piperidines are ideal pharmaceutical building blocks owing to the prevalence of in commercial drugs. Here, we report an electrochemical method for cyanation heterocycle adjacent nitrogen without requiring protection or substitution N–H bond. The reaction utilizes ABNO (9-azabicyclononane N-oxyl) as a catalytic mediator. Electrochemical oxidation generates corresponding oxoammonium species, which promotes dehydrogenation 2° piperidine cyclic imine, followed by addition cyanide....
Using captured waste carbon dioxide (CCU) as a chemical reagent is an attractive means to add value capture and storage (CCS) high-priority target for manufacturing. One promising route copolymerize epoxides, prepare aliphatic polycarbonates. In this study, three homogeneous dinuclear Zn Mg catalysts, previously reported by our group (see Kember, M. R.; Knight, P. D.; Reung, T. Williams, C. K Angew. Chem., Int. Ed. 2009, 48, 931–933 K. J. Am. Chem. Soc. 2012, 134, 15676–15679) have been...
Abstract Despite great advances in metal‐catalyzed cross‐coupling reactions, their efficacy is often compromised by side reducing the yield, or requiring a large excess of one component. Suzuki–Miyaura no exception, as boronic acid functionality can be susceptible to range undesired processes. A number methods have been developed mitigate these and herein we focus on “slow‐release” strategy. These conditions involve deployment “masking” reagent that protects vulnerable from degradation,...
The use of ferrocene mediators offers significant advantages over direct electrolysis in the generation and functionalization radicals from benzylboronates.
Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an strategy for their preparation, yet current methods limited alkene-types tolerance electron-rich, readily oxidized functionalities, as well safety scalability. Herein, we report a method the number unactivated that is tolerant electron-rich functionality, giving products otherwise unattainable. Key to...
We report a general procedure for the direct mono- and di-hydrodefluorination of ArCF
The field of organic electrochemistry has regained significant interest over recent years. unique level control afforded to the user reaction kinetics and selectivity is a driving force behind this. use non-standard electrolysis waveforms, such as alternating polarity electrolysis, been shown offer degree variation that facilitates new opportunities in field. generation pulsed waveforms via introduction resting period during underexplored electrosynthesis. Recent case studies demonstrate...
Simple, rapid, and scaleable: In contrast to current procedures using corrosive HF/MF or MHF2 reagents (M=e.g. K), a wide range of trifluoroborates can be rapidly, simply, safely prepared from MF (M=K, Cs), RCO2H, boronic acid/ester in regular glassware (see figure; left versus right). The use L-(+)-tartaric acid as an alkali-metal sponge is key allows isolation RBF3M by simple stir/filter/evaporate sequence. Detailed facts importance specialist readers are published "Supporting...
Abstract The reduction of water has been achieved through a non‐noble‐metal‐based homogeneous catalyst system that is formed in situ. Optimisation the ligand quantities increased turnover numbers compared to preformed complexes. Mechanistic studies confirm heteroleptic Cu complex as active photosensitiser (PS) and an situ Fe–phosphido dimer catalyst. method used screen range ligands for PS, which led identification number structural features important longevity performance.
Abstract The choice of electrode material is critical for achieving optimal yields and selectivity in synthetic organic electrochemistry. imparts significant influence on the kinetics thermodynamics electron transfer, frequently defines success or failure a transformation. Electrode processes are complex so often empirical underlying mechanisms rationale unknown. In this review, we aim to highlight recent instances where offered, which should aid future reaction development.
The electrochemical hydrodefluorination of trifluoromethylketones under non-protic conditions make this single-step reaction at deeply reductive potentials uniquely amenable to challenging electron-rich substrates and reductively sensitive functionalities.
The development of sustainable C(sp3)–H functionalization methods is great interest to the pharmaceutical and agrochemical industries. Anodic oxidation an efficient means producing benzylic cations that can undergo subsequent in situ nucleophilic attack afford functionalized products. Herein, we demonstrate suitability carboxylic acids as nucleophiles yield esters. This method employs a series secondary substrates demonstrated on gram scale flow.
A crepuscular catalyst: Alkene migration catalyzed by [(RCN)2PdCl2] complexes proceeds through an in situ generated Pd-H species. Addition of a 1,5-diene inhibits and allows the slower background catalysis E/Z interconversion to be studied. Experimental computational results suggest this conformational equilibrium dipalladacycles (see picture). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
Abstract Die Suzuki‐Miyaura‐Kupplung ist eine der wenigen übergangsmetallkatalysierten Reaktionen zur C‐C‐Bindungsbildung, die weite Verbreitung in Forschungs‐ und industriellen Chemie gefunden haben. Obwohl Kupplung über allgemeine dreistufige Abfolge von oxidativer Addition, Transmetallierung reduktiver Eliminierung abläuft, gibt es Reihe Merkmalen, denen sich das Suzuki‐Miyaura‐Verfahren anderen Kreuzkupplungen unterscheidet. Dies betrifft vor allem Aktivierung des Borreagens für...
Amide bonds are ubiquitous and found in a myriad of functional molecules. Although formed reliable robust fashion, alternative amide bond disconnections provide flexibility synthetic control. Herein we describe an electrochemical method to form the non-amide C–N from direct benzylic C(sp3)–H amidation. Our approach is applied toward synthesis secondary amides by coupling substrates with substituted primary benzamides. The reaction has been scaled up multigram scale flow.