SummaryAn 8-day rat levator ani muscle assay for myotrophic activity is presented. Preliminary steroid screening results indicate that 19-nortestosterone and other 19-nor analogs of androgens promise to be effective protein-anabolic, relatively weak androgenic agents. Using the same dose levels testosterone, equal responses were produced, yet showed only testosterone exhibited strong activity. Androsterone possesses

Nidation of embryos was delayed from 1 to 45 days in rats ovariectomized on the 3rd day after mating, by subcutaneous injection 4 mg progesterone per day. Implantation until such time as μg estrone given addition progesterone. Recovery blastocysts one horn uterus during treatment and subsequent implantation other induced progesterone-estrogen indicates that are maintained a viable, but resting condition treatment. If were untreated for 8 days, nidation not observed when estrogen initiated...

0.63 mg. of 19-nortestosterone in 0.1 ml. corn oil, when injected into the fertilized eggs white leghorn hybrid strain chickens, “Wisco-white,” on 5th day incubation, completely inhibits development bursa Fabricius both sexes. In normal chick bursal primordium appears as a proliferated epithelial mass dorso-caudal to embryonal cloaca incubation. By 168 hours incubation it forms tubular structure; its terminal end enlarges vesicle 10th and becomes lymphoidal by 15th day. The is fully formed...

Melatonin in beeswax was implanted male weasels (Mustela erminea). Brown and white animals undergoing the spring change to brown pelage reproductive activity molted, grew a new coat, became reproductively quiescent after treatment. Controls retained or acquired coat developed maintained enlarged testes. Treated with pituitary autografts under kidney capsule hair growth initiated by plucking. It is suggested that pineal gland product, melatonin, initiates changes central nervous system...

The eosinophil cell of the blood was first described over 100 years ago (Wharton Jones, 1846), and since then has been subject many morphological, cytological, physiological investigations. However, despite vast array publications reviews, actual function this in health or disease still eludes investigator (Kirk, 1942; Bethell, Sturgis, Rundles Meyers, 1946). A number comprehensive studies have made during last 17 but most investigations were carried out either man guinea pig. Work other...

Graded doses of hydrocortisone, cortisone, corticosterone and diethylstilbestrol were administered to 2-week old cockerels for 7 days the amount fat in depots, blood liver was determined. Hydrocortisone inhibited growth, increased carcass lipids. is more potent two compounds. Cortisone had no effect on growth or content at any used. Diethylstilbestrol lipids stimulated deposition without inhibiting growth.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE RELAXATIVE HORMONE OF THE CORPUS LUTEUM. ITS PURIFICATION AND CONCENTRATION1H. L. Fevold, Frederick Hisaw, and R. K. MeyerCite this: J. Am. Chem. Soc. 1930, 52, 8, 3340–3348Publication Date (Print):August 1, 1930Publication History Published online1 May 2002Published inissue 1 August 1930https://pubs.acs.org/doi/10.1021/ja01371a051https://doi.org/10.1021/ja01371a051research-articleACS PublicationsRequest reuse permissionsArticle...

Growth and Reproduction of the Cotton Rat, Sigmodon hispidus hispidus, under Laboratory Conditions Get access Bert J. Meyer, Meyer Department Zoology, University Wisconsin, Madison, Wisconsin Search for other works by this author on: Oxford Academic Google Scholar Roland K. Journal Mammalogy, Volume 25, Issue 2, 25 May 1944, Pages 107–129, https://doi.org/10.2307/1375009 Published: 1944

The physiological effects of the oestrous hormone on female rat have been studied quite exhaustively and characteristie reactions produced are generally well known. However, literature is rather obscure effect oestrin growth development ovaries mature immature animals. Allen Doisy (1) reported that follicular had ability to induce sexual maturity in 24-day-old rats. was not discussed. Golding Ramirez (2) also ovarian follieular Twenty rats, including males females from two litters, were...

Curry's paradox Get access Robert K. Meyer, Meyer Australian National University and Indiana Search for other works by this author on: Oxford Academic Google Scholar Richard Routley, Routley J. Michael Dunn Analysis, Volume 39, Issue 3, June 1979, Pages 124–128, https://doi.org/10.1093/analys/39.3.124 Published: 01 1979

Summary Injection of 0.63 mg 19-nortestosterone into eggs prevents differentiation the bursa Fabricii. Chickens resulting from such treatment were unable to produce precipitins when challenged with a single intravenous injection BSA at 6 or 22 weeks age. surgically bursectomized 1 and 2 age along intact controls 12 Antibody response groups was significantly lower than control group. The responses did not differ one another. 1, 5 10 injected reinjected 34 chickens week less response, whereas...

Summary Two strains of chickens were thymectomized and/or bursectomized at 1 to 3 days after hatching and skin homografts made 4 or 6 age. Thymectomy delayed homograft rejection, but neither steroidal surgical bursectomy had any effect.

Ten-week-old gray leghorn cockerels with ureters surgically exteriorized so that 24-hour samples of feces free urine could be collected were treated DCA, cortisone acetate and ACTH. The stress exteriorizing the produced reduction in weight gains an increased excretion electrolytes nitrogenous wastes on days 3 4 following surgery. In addition there was some adrenal hypertrophy. DCA treatment resulted polyuria, polydipsia, sodium potassium retention, increase thiocyanate space. Cortisone...

WHEN an immature female rat is united in parabiosis with ovariectomized littermate, the ovaries of intact undergo hypertrophy (Kallas, 1930). This has been attributed to hypersecretion gonadotrophins by pituitary castrated rat, hormones which pass directly via blood partner where they stimulate (Bunster and Meyer, 1938; Biddulph, Meyer Gumbreck, 1940). It believed that gonadotrophin increases largely follicle stimulating hormone (Greep, 1940; Biddulph 1946). Daily injections small quantities...

The results of the researches Smith and Engle (1927), Zondek Aschheim (1927) many others have demonstrated dependence function gonad upon anterior pituitary gland. One very characteristic quality gonad, ovary in particular, is its rhythmical activity. This suggests a parallel activity probability pituitary-gonadal interrelationship. Such relationship was first suggested by (1929a) publication his study on gonad-stimulating hormones gonadectomized rat Avhich he stated that release complex...

IN THE ANIMAL KINGDOM adverse environmental conditions are met by many interesting adaptations: certain protoz0a develop cysts; insects pii′ pate; the Australian lungfish burrows into mud and secretes a gelatinous capsule which enables it to survive dry season; mammals in temperate sone react an complex state known as hiberna′ tion. These depend upon grasses for their chief source of food. Many them live frozen subterranean during long winter months. Characteristically they able tolerate...

The idea that the corpus luteum is responsible for inhibition of ovulation seems to have been first elaborated by Beard and Prenant. experimental proof inhibitory action has attacked in many different ways. two most general methods based on anatomical physiological modifications reproductive tract, correlated with presence or absence a functional luteum, and, changes produced injection extracts lutein tissue. Corner Hurni reported negative results an attempt inhibit injecting normal white...

Smith and Engle showed that the anterior lobe of hypophysis guinea pig in oestrum is less potent its gonad stimulating power than animals dioestrum. Burch Cunningham reported injection a commercial placental extract, containing considerable amounts oestrin, into adult, castrate, female rats tends to increase pituitaries such animals, as compared with non-injected castrate controls approximately same weight. The period their experiment was 6 days dosage employed from Thirty-four immature...

Summary Removal of the bursa Fabricius at 1 day age effectively prevents a large percentage animals from producing precipitins to bovine serum albumin (BSA) when inoculations are made 20 weeks age. Bursectomy 10 days is less effective. Two steroid hormones, 19-nortestosterone and 17-ethyl-19-nortestosterone, administered on 12th or 13th incubation, cause 5- 20-fold reduction in bursal weight. Correspondingly, precipitin production against BSA grossly impaired. Spleen, thymus body weights...