A5100412087- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Connective tissue disorders research
- Spinal Dysraphism and Malformations
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Neurofibromatosis and Schwannoma Cases
- Hip disorders and treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Cord Injury Research
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Bone Tumor Diagnosis and Treatments
- Shoulder Injury and Treatment
- Genetic factors in colorectal cancer
- Shoulder and Clavicle Injuries
- Anesthesia and Pain Management
- Congenital heart defects research
- Congenital Diaphragmatic Hernia Studies
- Intracranial Aneurysms: Treatment and Complications
- Pectus Deformity Diagnosis and Treatment
- Bone fractures and treatments
- Growth Hormone and Insulin-like Growth Factors
Nanjing Drum Tower Hospital
2016-2025
Southwest University
2025
Nanjing Medical University
2012-2024
Nanjing University of Chinese Medicine
2024
Anhui Provincial Children's Hospital
2024
Guangzhou First People's Hospital
2009-2024
Guangzhou Medical University
2009-2024
South China University of Technology
2024
Wenzhou Medical University
2024
Shenzhen Nanshan Center for Chronic Disease Control
2024
MicroRNA‐155 (miR‐155) has been implicated as a central regulator of the immune system. We have previously reported that miR‐155 negatively regulates Helicobacter pylori ( H. )‐induced inflammation, but molecular mechanism regulating inflammation is not fully clear. Here, we identified myeloid differentiation protein 88 (MyD88) target gene miR‐155, and found decreased MyD88 expression at mRNA message level, suggesting miR‐155‐mediated inhibition post‐transcriptional event. Furthermore,...
A prospective, cross-sectional study.To investigate the normal values of sagittal spinal and pelvic parameters in Chinese populations to determine influence age, sex, weight, ethnicity on variations these parameters.A few studies have been conducted evaluate morphology orientation pelvis asymptomatic adults Caucasian populations. However, there is still a lack investigation concerning range alignment Asian populations.A cohort 260 adult volunteers from Han was prospectively recruited. The...
Abstract Adolescent idiopathic scoliosis (AIS) is a structural deformity of the spine affecting millions children. As complex disease, genetic aetiology AIS remains obscure. Here we report results four-stage genome-wide association study (GWAS) conducted in sample 4,317 patients and 6,016 controls. Overall, identify three new susceptibility loci at 1p36.32 near AJAP1 (rs241215, P combined =2.95 × 10 −9 ), 2q36.1 between PAX3 EPHA4 (rs13398147, =7.59 −13 ) 18q21.33 BCL-2 (rs4940576, =2.22 −12...
In Brief Study Design. A retrospective radiographical study investigated the sagittal alignment in healthy Chinese girls and with idiopathic thoracic scoliosis (T-AIS). Objective. To evaluate of pelvis spine to assess whether pelvic morphology differed between white AIS. Summary Background Data. It has been shown that patients AIS have an abnormal spinopelvic balance morphology. Race is a determinant factor spinal serves as reminder when planning surgical reconstruction for deformity. Until...
The genetic architecture of adolescent idiopathic scoliosis (AIS) remains poorly understood. Here we present the result a 4-stage genome-wide association study composed 5,953 AIS patients and 8,137 controls. Overall, identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 (Pcombined = 1.19 × 10−13, OR 1.21, 95% CI 1.10–1.32), rs7633294 3p14.1 MAGI1 1.85 10−12, 1.20, 1.09–1.32), rs9810566 3q26.2 TNIK 1.14 10−11, 1.19, 1.08-1.32). We also confirmed recently reported...
Cardiolipin (CL) is a mitochondrial signature phospholipid that required for membrane structure, respiration, dynamics, and mitophagy. Oxidative damage of CL by reactive oxygen species implicated in the pathogenesis Parkinson's disease (PD), but underlying cause remains elusive. This work investigated role ALCAT1, an acyltransferase catalyzes pathological remodeling various aging-related diseases, mouse model PD induced 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP). We show MPTP...
Scaffolds loaded with antibacterial agents and osteogenic drugs are considered essential tools for repairing bone defects caused by osteomyelitis. However, the simultaneous release of two leads to premature osteogenesis subsequent sequestrum formation in pathological situation unthorough antibiosis.In this study, a spatiotemporal drug-release polydopamine-functionalized mesoporous silicon nanoparticle (MSN) core/shell drug delivery system silver (Ag) nanoparticles dexamethasone (Dex) was...
A comparison between the smartphone-aided measurement method and manual for Cobb angle in adolescent idiopathic scoliosis.To evaluate reliability error compare its with those of method.The development smartphones has provided new opportunities that integrate mobile technology into daily clinical practice. Smartphone applications can provide quick assistance diagnosis treatment disease. Cobbmeter is a smartphone application designed on Apple iPhone smartphones. There no study this method.:...
This was a cross-sectional study.The present study aimed to explore the differences in leptin bioavailability between adolescent idiopathic scoliosis (AIS) and healthy age-matched girls Chinese Han population.AIS is common spinal deformity mainly occurring during peripubertal period. The development of related relative anterior overgrowth. AIS also have associated lower body mass index (BMI) bone mineral status. Leptin, together with soluble receptor (sOB-R), shown play an important role...
Study Design. Retrospective study. Objective. To compare the long-term outcomes of correction surgery for Lenke 1A scoliosis patients among those with non-Substantially Touched Vertebra (nSTV), nSTV+1, or STV selected as lowest instrumented vertebra (LIV). Summary Background Data. Previous studies have documented good when last touching (LTV) was LIV; however, it is sometimes confusing to determine proper LTV central sacral vertical line (CSVL) slightly touches vertebra. Methods. A total 104...
In Brief Study Design. Retrospective case series. Objective. This study reviewed the overall prevalence and indications of revision surgical procedures for adult scoliosis in a single institution. this largest single-institution series, surgery was required relatively low proportion cases (7.61%). The main were implant breakage, deformity progression, infection. Summary Background Data. Spine fusion is considered as final therapeutic intervention management scoliosis. However, reports on...
Study Design. A retrospective study. Objective. To investigate whether the mismatch between proximal junctional angle (PJA) and rod contouring contributed to occurrence of postoperative kyphosis (PJK) in degenerative scoliosis. Summary Background Data. PJK is one complications treatment scoliosis, PI-LL increased stiffness are supposed be etiology PJK. However, impact on has not been fully illustrated. Methods. study was performed 27 consecutive scoliosis patients (three males 24 females)...
Study Design. A genetic association study of GPR126 gene with adolescent idiopathic scoliosis (AIS) in the Chinese population. Objective. To investigate whether rs9403380, rs6570507, and rs7774095 are susceptible locus AIS to further determine functional variants regulating expression tissues AIS. Summary Background Data. Previous studies have identified several new susceptibility for gene. No have, however, investigated AIS, regulatory role remains obscure. Methods. Rs9403380, were...
Though several studies have reported the incidence of intraspinal neural axis abnormalities in infantile and juvenile "presumed idiopathic" scoliosis, there has been a varying prevalence ranging from 11.1 to 26.0 % based on limited sample size. Therefore, such inconclusive findings resulted some questions MRI-associated role management these patients. We aimed investigate distribution anomalies patients with scoliosis explore radiographic clinical indicators large A total 504 diagnosed were...
Abstract Background and Aims Hepatic ischemia–reperfusion injury (IRI) is a common complication of hepatectomy liver transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Regulator G‐protein signaling 14 (RGS14) multifunctional scaffolding protein that integrates mitogen‐activated kinase (MAPK) pathways. role RGS14 in remains unclear. Approach Results We found expression increased mice subjected to (IR) surgery during hypoxia reoxygenation...
Study Design. This was a case-control study. Objective. study aimed to investigate the body composition and its correlation with leptin soluble receptor (sOB-R) levels in girls adolescent idiopathic scoliosis (AIS) compared healthy controls. Summary of Background Data. Patients AIS are associated lower weight, taller stature, mass index (BMI), deranged bone quality. Despite widely reported BMI weight AIS, these patients not thoroughly studied sufficient sample size. Leptin is an important...
To investigate the accuracy of O-arm navigation-assisted screw insertion in extremely small thoracic pedicles and to compare it with free-hand pedicle adolescent idiopathic scoliosis (AIS). A total 344 screws were inserted apical region (defined as 2 vertebrae above below apex each) 46 AIS patients (age range 13–18 years) navigation 712 92 11–17 technique. According narrowest diameter orthogonal long axis on a trajectory entering vertebral body preoperative computed tomography, classified...
A retrospective radiographical study.To determine the association between disc degeneration and spinal malalignment on both coronal sagittal planes in patients with degenerative lumbar scoliosis (DLS).In recent years, a thorough understanding of balance alignment has become more important treating DLS. Although discs been generally accepted as main cause DLS, to date no study documented relationships curve magnitude well imbalance.In this study, 57 DLS were recruited. Degeneration apical...