A5045791266- Pregnancy-related medical research
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Prion Diseases and Protein Misfolding
- Biotin and Related Studies
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Autophagy in Disease and Therapy
- Menstrual Health and Disorders
- Memory and Neural Mechanisms
- Neuroscience of respiration and sleep
- Hypothalamic control of reproductive hormones
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
- Click Chemistry and Applications
- Attention Deficit Hyperactivity Disorder
- Transgenic Plants and Applications
- Neurotransmitter Receptor Influence on Behavior
UK Dementia Research Institute
2019-2023
University of Cambridge
2019-2023
Granta Design (United Kingdom)
2023
Universitat Jaume I
2015-2021
Florey Institute of Neuroscience and Mental Health
2018
Abstract The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target for misfolding neurodegenerative diseases, in which its overactivation results sustained translational repression leading to synapse loss and neurodegeneration. In mouse models of these disorders, from Alzheimer’s prion disease, modulation the pathway—including by licensed drug, trazodone—restores global synthesis rates with profound neuroprotective effects. However, precise nature impairment,...
Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature this modulation has been widespread monoamine projections to telencephalon. However, nucleus incertus (NI) pontine tegmentum provides a strong GABAergic peptidergic innervation hippocampus, basal forebrain, amygdala, prefrontal cortex, related regions; represents parallel source ascending domains. NI neurons express multiple peptides, including...
The medial septum (MS) complex modulates hippocampal function and related behaviours. Septohippocampal projections promote control different forms of synchronization. Specifically, GABAergic cholinergic targeting the formation from MS provide bursting discharges to theta rhythm, or tonic activity gamma oscillations. In turn, is targeted by ascending hypothalamus brainstem. One these arises nucleus incertus in pontine tegmentum, which contains GABA neurons that co-express neuropeptide...
Spatial learning and memory processes depend on anatomical functional interactions between the hippocampus entorhinal cortex. A key neurophysiological component of these is hippocampal theta rhythm, which can be driven from subcortical areas including pontine nucleus incertus (NI). The NI contains largest population neurons that produce presumably release neuropeptide, relaxin-3, acts via G i/o -protein-coupled receptor, relaxin-family peptide 3 receptor (RXFP3). activation induces general...
Methylphenidate (MPD) is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD). Alterations in septal driven hippocampal theta rhythm may underlie deficits observed these patients. Amongst others, the septo-hippocampal connections have long been acknowledged be important preserving function. Thus, we wanted ascertain if MPD administration, which improves patients, could affect areas connecting with hippocampus. We used low and orally...
Abstract The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target for misfolding neurodegenerative diseases, in which its overactivation results sustained translational repression leading to synapse loss and neurodegeneration. In mouse models of these disorders, from Alzheimer’s prion disease, modulation the pathway - including by licensed drug, trazodone restores global synthesis rates with profound neuroprotective effects. However, precise nature impairment,...