A5003927719- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Reproductive biology and impacts on aquatic species
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Regulation of Appetite and Obesity
- Advanced Glycation End Products research
- Lipoproteins and Cardiovascular Health
- Mosquito-borne diseases and control
- Adipose Tissue and Metabolism
- Congenital heart defects research
- Neurological Disease Mechanisms and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Apelin-related biomedical research
- Acute Ischemic Stroke Management
- Biochemical effects in animals
- Developmental Biology and Gene Regulation
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Phytochemistry and Bioactivity Studies
- Protease and Inhibitor Mechanisms
Inserm
2015-2024
Écologie Marine Tropicale des Océans Pacifique et Indien
2015-2024
Karlsruhe Institute of Technology
2013-2021
Centre Hospitalier Universitaire de La Réunion
2020
Observatoire des Sciences de l'Univers de la Réunion
2014-2017
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2015-2016
Institut de Recherche en Santé, Environnement et Travail
2012-2016
Université de Rennes
2010-2016
Zero to Three
2016
Centre de Recherche sur l'Inflammation
2015
Abstract The zebrafish has become a new model for adult neurogenesis, owing to its abundant neurogenic areas in most brain subdivisions. Radial glia‐like cells, actively proliferating and label‐retaining progenitors have been described these areas. In the telencephalon, this complexity is enhanced by an organization of ventricular zone (VZ) fast slow‐dividing domains, suggesting existence heterogeneous progenitor types. work, we studied expression various transgenic or immunocytochemical...
Abstract Coronavirus disease 2019 (COVID-19) pandemic is affecting millions of patients worldwide. The consequences initial exposure to SARS-CoV-2 go beyond pulmonary damage, with a particular impact on lipid metabolism. Decreased levels in HDL-C were reported COVID-19 patients. Since HDL particles display antioxidant, anti-inflammatory and potential anti-infectious properties, we aimed at characterizing proteome functionality during relative healthy subjects. HDLs isolated from plasma 8...
Zika virus (ZIKV) is an emerging mosquito-borne of medical concern. ZIKV infection may represent a serious disease, causing neonatal microcephaly and neurological disorders. Nowadays, there no approved antiviral against ZIKV. Several indigenous or endemic medicinal plants from Mascarene archipelago in Indian Ocean have been found able to inhibit infection. The purpose our study was determine whether essential oil (EO) Reunion Island plant Ayapana triplinervis, whose thymohydroquinone...
Neurosteroids are defined as steroids de novo synthesized in the central nervous system. While production of neurosteroids is well documented mammals and amphibians, there less information about teleosts, largest group fish. Teleosts have long been known for their high brain aromatase 5α-reductase activities, but recent data now document capacity fish to produce a large variety sex steroids. This article aims at reviewing available regarding expression and/or activity main steroidogenic...
The brain of adult teleost fish exhibits several unique and interesting features, notably an intense neurogenic activity linked to persistence radial glial cells acting as neural progenitors, a high aromatase supported by strong expression the cyp19a1b gene. Strikingly, is restricted cells, suggesting that estrogens are able modulate their activity. This raises question origin, central or peripheral, C19 androgens available for aromatization. study aimed investigate other main steroidogenic...
Abstract The teleost brain has the remarkable ability to generate new neurons and repair injuries during adult life stages. Maintaining life-long neurogenesis requires careful management of neural stem cell pools. In a genome-wide expression screen for transcription regulators, id1 gene, encoding negative regulator E-proteins, was found be upregulated in response injury. mapped quiescent type I cells telencephalic niche. Gain loss function vivo demonstrated that Id1 promotes quiescence....
Antirhea borbonica (A. borbonica) is an endemic plant from the Mascarene archipelago in Indian Ocean commonly used traditional medicine for its health benefits. This study aims (1) at exploring polyphenols profiles two types of extracts—aqueous (herbal infusion) and acetonic (polyphenol rich) extracts A. leaves—and (2) evaluating their potential toxicity vivo first time. We demonstrated that, whatever type extraction used, both displayed significant antioxidant properties acid phenolic...
The renal fibrotic process is characterized by a chronic inflammatory state and oxidative stress. Antirhea borbonica (A. borbonica) French medicinal plant found in Reunion Island known for its antioxidant anti-inflammatory activities mostly related to high polyphenols content. We investigated whether oral administration of polyphenol-rich extract from A. could exert vivo curative anti-renal fibrosis effect. To this aim, three days after unilateral ureteral obstruction (UUO), mice were daily...
The zebrafish has become a model to study adult vertebrate neurogenesis. In particular, the telencephalon been an intensely studied structure in brain. Differential expression of transcriptional regulators (TRs) is key feature development and tissue homeostasis. Here we report map 1,202 TR genes zebrafish. Our results are summarized database with search clustering functions identify expressed particular regions telencephalon. We classified 562 into 13 distinct patterns, including...
Abstract A growing body of evidence supports hyperglycemia as a putative contributor to several brain dysfunctions observed in diabetes patients, such impaired memory capacity, neural plasticity, and neurogenic processes. Thanks the persistence radial glial cells acting stem cells, adult zebrafish constitutes relevant model investigate constitutive injury‐induced neurogenesis vertebrates. However, there is limited understanding impact on dysfunction model. This work aimed at exploring acute...
Background and aimsAtherothrombotic plaques of type 2 diabetic (T2D) patients are characterized by an increased neovascularization intraplaque hemorrhage. The clearance erythrocytes may be carried out vascular cells. We explored the potential human endothelial cells to bind phagocyte in vitro aged and/or glycated as well obtained from patients.MethodsFresh, glycated-aged healthy volunteers T2D were tested for their binding phagocytosis capacity functional consequences on (viability,...
Diabetes constitutes a major health problem associated with severe complications. In hyperglycemic conditions, chronically increased oxidation and glycation of circulating components lead to advanced end-products (AGEs) formation, key contributor in diabetes complication progression. line literature documenting the beneficial properties herbal teas, this study evaluates antioxidant/glycant Antirhea borbonica (Ab). Ab aqueous extract effects were tested on human albumin or erythrocytes...