A5078238212- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Adenosine and Purinergic Signaling
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Smoking Behavior and Cessation
- Adipose Tissue and Metabolism
- Pharmacological Receptor Mechanisms and Effects
- Vagus Nerve Stimulation Research
- Lipoproteins and Cardiovascular Health
- Single-cell and spatial transcriptomics
- Memory and Neural Mechanisms
- Thermal Regulation in Medicine
- Cholesterol and Lipid Metabolism
- interferon and immune responses
- Nerve injury and regeneration
- Atherosclerosis and Cardiovascular Diseases
- Stress Responses and Cortisol
- T-cell and B-cell Immunology
University of California, Irvine
2023-2024
Hamilton College
2017-2022
National Institute of Diabetes and Digestive and Kidney Diseases
2020-2021
National Institutes of Health
2021
Ionis Pharmaceuticals (United States)
2018
New York University
2018
University of Freiburg
2018
NYU Langone Health
2018
Animal models have been used to explore factors that regulate atherosclerosis. More recently, they study the promote loss of macrophages and reduction in lesion size after lowering plasma cholesterol levels. However, current animal atherosclerosis regression require challenging surgeries, time-consuming breeding strategies, methods block liver lipoprotein secretion.We sought develop a more direct or time-effective method create then reverse hypercholesterolemia via transient knockdown...
Cigarette smoking remains a leading cause of preventable disease and death worldwide. Due to the devastating negative health effects smoking, many users attempt quit, but few are successful in long-term. Thus, there is critical need for novel therapeutic approaches. In these investigations, we sought examine whether cannabidiol (CBD) has potential be repurposed as nicotine cessation therapeutic. first study, male female mice were trained respond intravenous infusions at either low or...
Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A 1 receptors (A AR, encoded by the Adora1 gene) to examine contribution of these Intracerebroventricular injection selective AR agonist (Cl-ENBA, 5'-chloro-5'-deoxy- N 6 -endo-norbornyladenosine) produced hypothermia, which was reduced in with deletion neurons. non-brain penetrant [SPA, -(p-sulfophenyl) adenosine] also caused wild type but not suggesting that peripheral Mice...
Abstract The opioid epidemic has led to a devastating loss of life nationwide. Of those dependent on opioids, many individuals desire quit or reduce use, but their efforts are often unsuccessful given the powerful reinforcing properties associated with drugs, especially fentanyl its high potency and speed onset. Here, we developed novel theraputic based newly artificial intelligence (AI)-based platform, which was rationally designed identify markers dysregulation from human drug user...
Bombesin receptor subtype-3 (BRS3) is an orphan that regulates energy homeostasis. We compared Brs3 driver mice with constitutive or inducible Cre recombinase activity. The BRS3-Cre show a reporter signal (Cre-dependent tdTomato) in the adult brain because of lineage tracing dentate gyrus, striatal patches, and indusium griseum, addition to sites previously identified (including hypothalamic amygdala subregions, parabrachial nucleus). detected expression gyrus at day 23 but not postnatal 1 5...
Abstract The preoptic area (POA) is a key region controlling body temperature (Tb), dictating thermogenic, cardiovascular, and behavioral responses to regulate Tb. Known POA neuronal populations reduce Tb when activated; population that increases upon activation has not yet been reported. We now identify bombesin-like receptor 3 (BRS3)-expressing (POA BRS3 ) neurons as having this missing functionality. an orphan regulates energy cardiovascular homeostasis, but the relevant neural circuits...
The recent increase in the use of nicotine products by teenagers has revealed an urgent need to better understand impact on adolescent brain. Here, we sought examine actions extracellular ATP as a neurotransmitter and investigate whether nicotinic signaling interact during adolescence. With GRAB (G-protein-coupled receptor activation-based sensor), first demonstrated that induces release medial habenula, brain region involved aversion withdrawal. Using patch-clamp electrophysiology, then...