A5027025934- Gout, Hyperuricemia, Uric Acid
- Single-cell and spatial transcriptomics
- DNA Repair Mechanisms
- Vitamin C and Antioxidants Research
- Telomeres, Telomerase, and Senescence
- Animal Disease Management and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Synthesis and biological activity
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Natural Compounds in Disease Treatment
- Cancer-related molecular mechanisms research
- Viral Infections and Vectors
- Inflammasome and immune disorders
- Advanced biosensing and bioanalysis techniques
- Eicosanoids and Hypertension Pharmacology
- Viral Infections and Immunology Research
- Biosensors and Analytical Detection
- Hormonal Regulation and Hypertension
- Viral gastroenteritis research and epidemiology
- Natural product bioactivities and synthesis
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
Chongqing University
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Wenzhou University
2024
Dalian Jinzhou First People's Hospital
2024
Affiliated Hospital of North Sichuan Medical College
2021-2023
North Sichuan Medical University
2021
Dynamic tracing of intracellular telomerase activity plays a crucial role in cancer cell recognition and correspondingly earlier diagnosis personalized precision therapy. However, due to the complexity required reaction system insufficient loading components into cells, achieving high-fidelity determination is still challenge. Herein, an Aptamer-Liposome mediated Telomerase activated poly-Molecular beacon Arborescent Nanoassembly(ALTMAN) approach was described for direct visualization...
Sepsis is a syndrome of organ dysfunction caused by an uncontrolled inflammatory response, which can seriously endanger life. Currently, there still shortage specific therapeutic drugs. Quercetin and its natural derivatives have received lot attention recently for their potential in treating sepsis. Here, we provide comprehensive summary the recent research progress on quercetin derivatives, with focus mechanisms antioxidation anti-inflammation. To obtain necessary information, conducted...
Lung cancer has one of the highest mortality rates worldwide, with non-small-cell lung (NSCLC) constituting approximately 85% all cases. Demethylzeylasteral (DEM), extracted from Tripterygium wilfordii Hook F, exhibits notable anti-tumor properties. In this study, we revealed that DEM could effectively induce NSCLC cell apoptosis. Specifically, can dose-dependently suppress viability and migration human cells. RNA-seq analysis regulates P53-signaling pathway, which was further validated by...
Enterovirus A71 (EV-A71) is a major pathogen causing hand, foot, and mouth disease (HFMD) in children worldwide. It can lead to severe gastrointestinal, pulmonary, neurological complications. The innate immune system, which rapidly detects pathogens via pathogen-associated molecular patterns or pathogen-encoded effectors, serves as the first defensive line against EV-A71 infection. Concurrently, virus has developed various sophisticated strategies evade host antiviral responses establish...
The RNA-binding protein tristetraprolin (TTP) is an anti-inflammatory factor that prompts the mRNA decay of target mRNAs and involved in inflammatory diseases such as rheumatoid arthritis (RA). TTP regulated by phosphorylation, phosphatase 2A (PP2A) can dephosphorylate to activate its mRNA-degrading function. Some small molecules enhance PP2A activation. Short interfering RNA (siRNA) targeting expression or agonist (Arctigenin) was administered monosodium urate (MSU) crystal-induced J774A.1...
Abstract Background Previous studies have revealed that Sirt3 deficiency is associated with several inflammatory responses. The purpose of this study to investigate the role and potential molecular mechanisms in inflammation induced by monosodium urate (MSU) crystals. Methods expression level peripheral blood mononuclear cells (PBMCs) patients gout was measured. Function mechanism MSU crystal-induced were investigated bone marrow-derived macrophages (BMDMs), C57BL/6 mouse, −/− mouse. Results...
The CYP2D6 enzyme is crucial for the metabolism and disposition of a variety drugs. This study was conducted to examine relationship between gene polymorphisms response angiotensin receptor blocker (ARB)-based treatment in patients Chinese Bai ethnicity with hypertension.
Accurate analysis of S-phase fraction is crucial for the assessment cell proliferation levels, tumor malignancy and prognostic effects treatment. Most currently developed methods rely on flow cytometric DNA content determination. However, lack standardized procedures sample interpretation cycle fitting graphs poses a significant limitation in clinical practice utilizing cytometry to measure based content. Herein, we an approach analyzing cells telomerase activity Briefly, this distinguishes...