A5014183468- Inflammatory Bowel Disease
- Microscopic Colitis
- Insect-Plant Interactions and Control
- Research on scale insects
- Gastrointestinal Bleeding Diagnosis and Treatment
- Phytoplasmas and Hemiptera pathogens
- Dialysis and Renal Disease Management
- Bioactive natural compounds
- Collembola Taxonomy and Ecology Studies
- HIV Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Potassium and Related Disorders
- Hepatitis C virus research
- Bone and Joint Diseases
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- Organ Transplantation Techniques and Outcomes
- Eosinophilic Esophagitis
- Digestive system and related health
- Celiac Disease Research and Management
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- RNA regulation and disease
- Renal Transplantation Outcomes and Treatments
- Gastrointestinal motility and disorders
Sixth Affiliated Hospital of Sun Yat-sen University
2023-2025
Sun Yat-sen University
2023-2025
Dongshin University
2024
Creative Commons
2018
Peking University First Hospital
2018
Peking University
2018
Background and Aims: Inflammatory bowel disease (IBD) requires effective treatment options. Upadacitinib, a Janus kinase 1 (JAK1) inhibitor, has shown effectiveness in trials for Crohn’s (CD) ulcerative colitis (UC). This study evaluates its real-world safety. Methods: We conducted multicenter retrospective cohort tertiary care centers, involving patients treated with upadacitinib from January 2023 to September 2024. The included adult aged 18 years or older, diagnosed UC CD, who received at...
The role of viral factors in the pathogenesis chronic hepatitis C is unknown. objective present study was to characterize markers virus (HCV) infection and replication liver biopsy specimens obtained from 65 genotype 1-infected subjects, including 31 who were coinfected with human immunodeficiency (HIV), analyze associations between intrahepatic disease severity. percentages cells harboring HCV genomes (%G) replicative-intermediate RNAs (%RI) evaluated using strand-specific situ...
Abstract Background Inflammatory bowel disease (IBD) requires effective treatment options. Upadacitinib, a Janus kinase 1 (JAK1) inhibitor, has shown effectiveness in trials for Crohn’s (CD) and ulcerative colitis (UC). This study evaluates its real-world safety. Methods We conducted multicenter retrospective cohort tertiary care centers, involving patients treated with upadacitinib from January 2023 to September 2024. The included adult aged 18 years or older, diagnosed UC CD, who received...
Abstract Background The optimal treatment strategy for moderate-to-severe ulcerative colitis (UC) remains challenging. This study aimed to evaluate the efficacy and safety of combination therapy with vedolizumab (VDZ) plus upadacitinib (UPA) compared VDZ monotherapy. Methods In this multicenter, prospective, randomized controlled trial, patients UC were receive either (300mg at weeks 0, 2, 6, then every 8 through week 54) UPA (45mg daily weeks) or Primary endpoints included clinical...
Iron status has been implicated in gastrointestinal diseases and gut microbiota, however, confounding factors may influence these associations.
Ustekinumab (UST) is recommended as the first-line treatment for patients with moderate to severe Crohn's disease (CD). However, efficacy of certain may be suboptimal and necessitate intensive or modification regimen. We sought establish a nomogram model predict short-term effectiveness UST in CD patients. established derivation cohort comprising diagnosed treated at Sixth Affiliated Hospital Sun Yat-sen University from May 2020 July 2023. The patient data, including demographic clinical...
To establish a HPLC method for determination of 4 components in different varieties vinegar backed Rhizoma Curcuma.The was established by using an Elite Hypersil ODS2 column (4.6 mm x 250 mm, 5 microm). The mobile phase comprising acetonitrile (A) and water (B) used to elute the targets gradient elution mode. Flow rate detection wavelength were set at 1 mL min(-1) 214 nm, respectively. temperature 25 degrees C injection volume 10 microL.All calibration curves showed good linearity with r >...
Abstract Background Previous studies have shown acute pancreatitis (AP) to be the most common pancreatic disease in inflammatory bowel (IBD) patients, with Crohn's (CD) patients exhibiting significantly higher incidence than ulcerative colitis (UC) patients. However, shared biological mechanisms remain elusive. This study aimed identify differentially expressed genes (DEGs) between CD and AP explore their associated molecular using bioinformatics approaches. Methods Microarray datasets...
CD43 is a cell surface sialoglycoprotein expressed by most cells of hematopoietic origin, including all T lymphocytes. Elimination expression gene targeting in the CEM line results its increased homotypic adhesion and binding to HIV-1 gp120. Here we report that CD43-negative show susceptibility infection viral replication compared with parental CD43+ line. Increased also was observed diminished secondary functional inactivation single allele. The CD43- were more susceptible HIV-1-induced...
Abstract Background Epidemiological studies have indicated a frequent co-occurrence of Graves' disease (GD) with other immune-mediated diseases (IMDs). However, the causal relationship between them remains uncertain. Objective This study aimed to establish GD and IMDs, as well investigate genetic foundation comorbidities. Methods We employed Mendelian randomization (MR) infer eight IMDs in East Asian population, namely, systemic lupus erythematosus (SLE), ulcerative colitis (UC), rheumatoid...
Rationale: Hyponatremia is one of the most common electrolyte disorders in patients on peritoneal dialysis (PD). It can be associated with severe consequences, higher morbidity and mortality. Therefore, hyponatremia should assessed monitored more carefully these patients. Patient concerns: A 55-year-old male PD patient progressively developed intractable was admitted to our hospital. Diagnoses: The observation that no significant salt lost kidney drainage prompted us seek underlying reasons...