A5101965522- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
Harbin Medical University
2019-2024
Second Affiliated Hospital of Harbin Medical University
2019-2024
Circular RNAs (circRNAs) and extracellular vesicles (EVs) are involved in various malignancies. We aimed to clarify the functions mechanisms of dysregulated circRNAs cells EVs cholangiocarcinoma (CCA).CircRNA microarray was used identify circRNA expression profiles CCA tissues bile-derived (BEVs). CCA-associated 1 (circ-CCAC1) measured by quantitative real-time PCR. The clinical importance circ-CCAC1 analyzed receiver operating characteristic curves, Fisher's exact test, Kaplan-Meier plots,...
Abstract Akirin2 is a key regulator of embryonic development and the innate immunity response. However, this regulator’s role in tumorigenesis especially cholangiocarcinoma (CCA) has not been thoroughly elucidated to date. In current work, we used RT-qPCR, western blot analysis, immunohistochemistry (IHC) explore expression level Akirin2, relationship between levels clinicopathological characteristics was evaluated. The biological functions were examined vitro vivo by using lentiviral vector...
This study aimed to investigate the effects and regulatory mechanism of long non-coding RNA HEIH in development breast cancer. The expression tumor tissues cancer cells was determined, followed by investigating dysregulation on cell viability, apoptosis, migration invasion. upregulated tissue samples lines. Suppression inhibited promoted decreased invasion MDA-MB-231 cells. Moreover, a negative relationship existed between miR-200b, regulated via regulating miR-200b. Pre-leukemia...
Abstract Background: Cholangiocarcinoma (CCA) is a mortal cancer with high mortality, whereas the function and mechanism of occurrence progression CCA are still mysterious. Long non-coding RNAs (lncRNAs) could as important regulators in carcinogenesis progression. Growing evidences have indicated that novel lncRNA linc00473 plays an role metastasis. However, its molecular remain unknown. Methods: The expression tissues cell lines was analyzed using qRT-PCR. Gain- loss-of-function experiments...
Table S2. Relationship between SPRY4-IT1 expression and clinicopathologic features of CCA patients. (DOCX 15Â kb)
Abstract Background MicroRNAs (miRNAs) are abnormally expressed in human tumors, including cholangiocarcinoma (CCA). miR-27a-3p was observed up-regulated CCA, but its functions CCA largely unknown.Methods CCK8 assay, Colony formation assays and Ki-67 staining employed to detect the cell growth. The autophagy proliferation relative-protein analyzed by western blot. immunofluorescence applied analyze expression level of LC3 I/II. Tumor xenografts used test role miR-27a-3p. Luciferase reporter...