A5064059607- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Neurofibromatosis and Schwannoma Cases
- Ophthalmology and Eye Disorders
- Spinal Fractures and Fixation Techniques
- Trauma and Emergency Care Studies
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Facial Nerve Paralysis Treatment and Research
- Spinal Cord Injury Research
- Diversity and Career in Medicine
- Growth Hormone and Insulin-like Growth Factors
- Neurogenesis and neuroplasticity mechanisms
- Neuroblastoma Research and Treatments
- Oral and Maxillofacial Pathology
- Protein Degradation and Inhibitors
- Brain Metastases and Treatment
- History of Medical Practice
- RNA modifications and cancer
University of Pittsburgh
2023-2024
University of Pittsburgh Medical Center
2023-2024
Neurological Surgery
2023-2024
Children's Hospital of Pittsburgh
2023
Glioblastoma is the most common primary, malignant brain tumor that remains uniformly lethal in nearly all cases as a result of extreme cellular heterogeneity, treatment resistance, and recurrence. A major hurdle therapeutic delivery to tumors blood–brain barrier (BBB), which tightly regulated vascular between parenchyma systemic circulation prevents distribution otherwise beneficial chemotherapeutics central nervous system tumors. To overcome obstacle drug beyond BBB, nanoparticle...
OBJECTIVE Numerous studies have investigated the impact of inflammatory factors in cancer, yet few attempts been made to investigate these markers skull base chordoma (SBC). Inflammatory values including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), lymphocyte-monocyte (LMR), systemic immune inflammation index (SII), and response (SIRI) can serve as prognostic various cancers. This study aimed determine whether influence overall survival (OS) or progression-free (PFS)...
BACKGROUND AND OBJECTIVE: Conventional protocols for inferior petrosal sinus sampling (IPSS) during the workup of hypercortisolemia require adrenocorticotrophic hormone (ACTH) measurement at multiple time points with corticotropic-releasing (CRH) used as a stimulator. Modernized evidence-based must also reflect increased utilization desmopressin (DDAVP) ACTH stimulation manufacturing shortage traditionally CRH continues. We model diagnostic accuracy and potential economic savings DDAVP...
The de novo development of cerebral arteriovenous malformations (AVMs) in adults is an exceedingly rare event that has prompted the theory a "second hit" required to induce AVM formation. authors document occipital adult decade and half after brain magnetic resonance imaging (MRI) disclosed no abnormality. A 31-year-old male with family history AVMs 14-year migraines visual auras seizures presented our service. Because onset first seizure migraine headaches at age 17, patient underwent...
Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced the hallmark histone mutation H3K27M, which results aberrantly permissive activation of oncogenic signaling pathways. Previous studies with altered H3K27 (DMG-H3K27a) have shown that RAS pathway, specifically through its downstream kinase, extracellular-signal-related kinase 5 (ERK5), critical for tumor growth. Further effectors ERK5 and their role DMG-H3K27a metabolic not been explored....
The supracerebellar infratentorial (SCIT) approach is a well-described corridor to lesions in the quadrigeminal cistern, pineal gland, and dorsal midbrain. It can be performed prone or sitting position. position offers benefit of gravity retraction cerebellum but comes at expense nonergonomic hand positioning potential risk air embolism. 3D exoscope an alternative operating microscope permits SCIT with excellent visualization. This video demonstrates exoscope-based for resection meningioma...
Introduction: Since its inception in 1989, the North American Skull Base Society (NASBS) has been instrumental innovating field of skull base surgery through clinical excellence and rigorous research. Many accomplishments achieved by society over past three decades may be attributed to strong leadership that shaping NASBS' identity. We aimed chronicle academic attributes NASBS presidents determine how trends have changed time as well offer valuable information for next generation surgeons.
Purpose: This study aims to test the viability of radiomic feature analysis as a model for predicting overall survival (OS) and progression free after surgery (PFSS) in skull base chordomas (SBCs) based on key features. It also determine if those features can be used classify SBCs into meaningful groups.
Background: The incidence of pituitary adenomas rises with age, leading to increased overall prevalence. Understanding the role surgery for nonfunctional (NFPAs) in elderly, especially increasingly used endoscopic endonasal approach (EEA) requires further study. A growing body research has demonstrated that frailty is a greater predictor poor outcomes than advanced age.
Introduction: Vestibular schwannomas (VS) are often managed with stereotactic radiosurgery (SRS). Tumor progression post-SRS presents a management challenge that sometimes necessitates further surgical intervention. The outcomes of facial nerve function following resection in these progressed cases particular concern.
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with a median survival of approximately 15 months, despite treatment, patients experiencing recurrence within 9 months resection. The propensity GBM exemplifies fatal course disease and remains an underlying area study as novel instances are encountered. authors present unique case 31-year-old male patient history cerebellomedullary junction astrocytoma who later developed supratentorial followed by centered...
Abstract Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced the hallmark histone mutation H3K27M, which results aberrantly permissive activation of oncogenic signaling pathways. Previous studies with altered H3K27 (DMG-H3K27a) have shown that RAS pathway, specifically through its downstream kinase, extracellular-signal-related kinase 5 (ERK5), critical for tumor growth. However, there remains a knowledge gap identifying effectors ERK and...
The authors present a case of 10-year-old female presenting with headaches and fever following retrosigmoid craniotomy incomplete prepontine neurenteric cyst resection. Neurological examination was unremarkable. Magnetic resonance imaging demonstrated hyperintense lesion. Endonasal approach offers direct access to the greatest chance total Following complete resection via endoscopic endonasal transclival approach, multilayer skull base reconstruction performed. Patient tolerated procedure...
Introduction: Temporal bone skull base pathologies represent a complex and heterogenous differential. Often biopsy of tumors in this location has significant morbidity due to their relationship adjacent critical neurovascular structures. Radiomics involves the use mathematical quantification imaging data beyond simple intensity, size, location. We aimed apply radiomics help predict tumor type.
Plute, Tritan BS*; Abou-Al-Shaar, Hussam MD‡; McDowell, Michael M. Mallela, Arka N. MD, MS‡; Snyderman, Carl H. MBA§; Gardner, Paul A. MD‡ Author Information
Our objective was to elucidate the demographic, academic, and career attributes of North American Skull Base Society (NASBS) presidents determine how leadership this society has changed over time.