A5084618595- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Hematopoietic Stem Cell Transplantation
- RNA Research and Splicing
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Esophageal Cancer Research and Treatment
- RNA regulation and disease
- Plant Stress Responses and Tolerance
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Mass Spectrometry Techniques and Applications
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Advanced Proteomics Techniques and Applications
- Glutathione Transferases and Polymorphisms
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
University of Gdańsk
2020-2023
Inserm
2022
Gdańsk Medical University
2022
Abstract Cell-based immunotherapies can provide safe and effective treatments for various disorders including autoimmunity, cancer, excessive proinflammatory events in sepsis or viral infections. However, to achieve this goal there is a need deeper understanding of mechanisms the intercellular interactions. Regulatory T cells (Tregs) are lymphocyte subset that maintain peripheral tolerance, whilst mesenchymal stem (MSCs) multipotent nonhematopoietic progenitor cells. Despite coming from...
Proteomics of human tissues and isolated cellular subpopulations create new opportunities for therapy monitoring a patients' treatment in the clinic. Important considerations such analysis include recovery adequate amounts protein reproducibility sample collection. In this study we compared several protocols proteomic preparation: i) filter-aided preparation (FASP), ii) in-solution digestion (ISD) iii) pressure-assisted (PCT) method. PCT method is known already decade [1], however it not...
We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined anti-CD20 antibody successfully treated remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion activation of TCR Vβ2 CD8+ cytotoxic T cells CD16 + CD56- NK cells. This is first presentation TCR-specific cell oligoclonal response in COVID-19. Our study suggests that depleted patients may effectively respond anti-SARS-CoV-2...
Abstract The Nrf2 pathway is an essential defense in a cell. It responds to oxidative and electrophilic stress via derepression of from Keap1-Cul3-mediated degradation, accumulation the nucleus transcriptional activation number detoxifying cell protective target genes. Here we report that normal cancer cells also express N-terminally truncated isoform (ΔN-Nrf2), which originates alternative promoter. Co-immunoprecipitation together with molecular dynamics simulation showed binding between...
Abstract The Nrf2 pathway is an essential defense in a cell. It responds to oxidative and electrophilic stress via derepression of from Keap1-Cul3-mediated degradation, accumulation the nucleus transcriptional activation number detoxifying cell protective genes. Here we report that normal cancer cells also express N-terminally truncated isoform (ΔN-Nrf2), which originates alternative promoter. Co-immunoprecipitation together with molecular dynamics simulation studies showed binding between...
Abstract The Major Histocompatibility Complex class I (MHC-I) molecules present antigenic peptides (AP) to CD8 + T cells for self versus non-self recognition. Loading of AP on MHC-I takes place in the endoplasmic reticulum (ER), upon shuttling cytoplasmic substrates ER. Understanding this process has been influenced by view that antigens are produced from proteasomal degradation cellular proteins. Recent observations intronic and untranslated region-derived as well non-AUG translation...