A5062192077- Genetics, Aging, and Longevity in Model Organisms
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Kawasaki Disease and Coronary Complications
- Advanced Fluorescence Microscopy Techniques
- Systemic Lupus Erythematosus Research
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Cell Image Analysis Techniques
- Neurobiology and Insect Physiology Research
- Inflammasome and immune disorders
Harvard University
2021
Massachusetts Institute of Technology
2020
McGovern Institute for Brain Research
2020
Brandeis University
2014
BACKGROUND. Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in (MIS-C). Gastrointestinal (GI) symptoms are common patients with MIS-C, and severe hyperinflammatory response ensues potential for cardiac complications. The cause of MIS-C has not been identified to date.
We recently developed expansion microscopy (ExM), which achieves nanoscale-precise imaging of specimens at ~70 nm resolution (with ~4.5x linear expansion) by isotropic swelling chemically processed, hydrogel-embedded tissue. ExM C. elegans is challenged its cuticle, stiff and impermeable to antibodies. Here we present a strategy, (ExCel), expand fixed, intact elegans. ExCel enables simultaneous readout fluorescent proteins, RNA, DNA location, anatomical structures resolutions ~65–75...
In neuroscientists' attempts to understand the long-term storage of memory, topics particular importance and interest are cellular system mechanisms maintenance (e.g., those sensitive ζ-inhibitory peptide, ZIP) induced by memory retrieval (i.e., reconsolidation). Much is known about each these processes in isolation, but less concerning how they interact. It that ZIP sensitivity share at least some molecular targets recycling α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, AMPA,...
Semiochemicals are volatile compounds that communicate specific meaning between individuals, and elicit behavioral and/or physiological responses mediated by highly sensitive olfactory pathways.Recent work suggests semiochemicals can activate multiple pathways at once, but the degree to which parallel activated same semiochemical interact, what consequences of such interactions are, remains a topic debate.Here we approached this question behaviorally, investigating whether rats could be...