A5035518204- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Balance, Gait, and Falls Prevention
- Neuroscience and Music Perception
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Diversity and Impact of Dance
- Neuroscience and Neuropharmacology Research
- Primate Behavior and Ecology
- Autism Spectrum Disorder Research
- Motor Control and Adaptation
- Genetic Neurodegenerative Diseases
- Virus-based gene therapy research
- Mindfulness and Compassion Interventions
- Regulation of Appetite and Obesity
- RNA Interference and Gene Delivery
- Memory and Neural Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Olfactory and Sensory Function Studies
- Pluripotent Stem Cells Research
- Neural and Behavioral Psychology Studies
- Xenotransplantation and immune response
- Transcranial Magnetic Stimulation Studies
University of Hertfordshire
2003-2024
University of Florida
2003
University of Cambridge
1992-2002
Middlesex University
1994
MRC Clinical Trials Unit at UCL
1983-1989
We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets. The protein was expressed 90–95% all nigral dopamine neurons and distributed by anterograde transport throughout their axonal dendritic projections. transduced developed severe neuronal pathology, including α-synuclein-positive cytoplasmic inclusions granular deposits; swollen, dystrophic, fragmented neuritis; shrunken pyknotic, densely...
The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) for Parkinson's disease is likely to depend on sustained delivery the appropriate amount target areas. Recombinant adeno-associated viral vectors (rAAVs) expressing GDNF may be a suitable system this purpose. aim study was define level that does not affect function normal dopamine (DA) neurons but provide anatomical and behavioral protection against an intrastriatal 6-hydroxydopamine (6-OHDA) lesion in common...
The effects of bilateral excitotoxic lesions 3 major sources afferents to the ventral striatum (nucleus accumbens) were compared on an open field test food neophobia allowing choice between familiar and novel food. Whereas basolateral amygdala subiculum had qualitatively similar reduce (although not affecting latency eat), increased decreased locomotor activity. In contrast, damage ventromedial prelimbic prefrontal cortex only affected initial measures. By comparison, nucleus accumbens...
Unilateral stereotaxic injections of 6-hydroxydopamine (6-OHDA) into the nigrostriatal bundle marmosets (Callithrix jacchus) produced substantial losses tyrosine hydroxylase immunoreactive neurons from substantia nigra, and mean dopamine (DA) depletions 98–99% in caudate nucleus, putamen nucleus accumbens, 91-97% frontal cortex, on side lesion. Noradrenaline (NA) 5-hydroxytryptamine (5-HT) levels were also affected. Behavioural tests conducted pre-operatively at regular intervals during...
Dance interventions have physical benefits for the elderly, especially those with Parkinson’s disease. This study assessed psychological of dance. A total 37 participants, either disease ( n = 22) or age-matched controls 15) completed mood questionnaires before and after a 10-week dance intervention. An overall reduction in disturbance specific anger were observed. In addition, less fatigue was found initially scoring higher depression. suggests that can provide both people findings...
Rhythmic auditory stimulation (RAS) has successfully helped regulate gait for people with Parkinson's disease. However, the way in which different cues and types of movements affect entrainment, synchronization, pacing stability not been directly compared aged without Parkinson's. Therefore, this study music metronomes (cue types) finger tapping, toe stepping on spot tasks to explore potential RAS training general use.Participants (aged 18-78 years) included (n = 30, Hoehn Yahr mean 1.78),...
Abstract Lesions of the subthalamic nucleus can restore some imbalances in motor output basal ganglia induced by nigrostriatal dopamine depletion, and have been proposed as a potential therapy for Parkinson's disease. Although there is substantial supporting evidence from experimental studies both rats primates, less information on effects lesions alone. In order to characterize side effects, present study evaluates behavioural unilateral excitotoxic that previously received either saline or...
Recent studies in non-human primates support a role for the subthalamic nucleus expression of parkinsonian symptomatology, and it has been proposed that lesions may provide surgical treatment symptoms Parkinson's disease humans. We have applied broad range behavioural tests to characterize effects on unilateral 6-hydroxydopamine (6-OHDA) lesioned marmoset (Callithrix jacchus). Thirteen marmosets were trained battery tasks conducted at regular intervals before after surgery. All received...
ObjectiveaaSpontaneous motor tempo (SMT), observed in walking, tapping and clapping, tends to occur around 2 Hz.Initiating controlling movement can be difficult for people with Parkinson's (PWP), but studies have not identified whether PWP differ from controls SMT.For community-based interventions, e.g.dancing, it would helpful know a baseline SMT optimize the tempi of cued activities.Therefore, this study compared finger (FT), toe (TT) stepping 'on spot' (SS) two groups healthy [age-matched...
Abstract Finger-tapping tasks are classically used to investigate sensorimotor synchronization in relation neutral auditory cues, such as metronomes. However, music is more commonly associated with an entrained bodily response, toe tapping, or dancing. Here we report experimental procedure that was designed bridge the gap between timing and intervention studies by directly comparing effects of metronome musical cue types on motor abilities across three naturalistic voluntary actions finger...
The study examined the importance of embryonic donor age for survival nigral grafts in 6-OHDA-lesioned marmosets. issue as to whether is critical primates controversial, because several early reports suggested that relatively old tissue could survive transplantation and produce functional benefits monkeys, contrast restrictive time dependence observed rodents. Embryonic marmoset donors embryos three different ages were employed: 1) E74 (Carnegie stage 18–19); 2) E83–84 23+); 3) E92–93...
The study examined the importance of embryonic donor age for survival nigral grafts in 6-OHDA–lesioned marmosets. issue as to whether is critical primates controversial, because several early reports suggested that relatively old tissue could survive transplantation and produce functional benefits monkeys, contrast restrictive time dependence observed rodents. Embryonic marmoset donors embryos three different ages were employed: 1) E74 (Carnegie stage 18-19); 2) E83-84 23+); 3) E92-93...