A5011320213- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Hormonal Regulation and Hypertension
- Cancer, Stress, Anesthesia, and Immune Response
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- RNA and protein synthesis mechanisms
Chinese University of Hong Kong
2023-2025
University of Hong Kong
2020-2025
Piwi-interacting RNAs (piRNAs) represent a novel class of small non-coding (ncRNAs) that have been shown to deregulated expression in several cancers, although their clinical significance colorectal cancer (CRC) remains unclear. With an aim delineating the piRNA distribution CRC, we conducted systematic discovery and validation piRNAs within two cohorts. In phase, profiled tumor adjacent normal tissues from 18 CRC patients by deep sequencing identified global downregulation CRC. Moreover,...
Background Anti-hypertensive drugs have been reported to demonstrate anti-inflammatory and anti-angiogenic effects. This study aims investigate the association between anti-hypertensive prognosis of colorectal cancer (CRC) patients. Methods Clinical data 1134 CRC patients with hypertensions prescription who had undergone curative surgery in our hospital 2005 2015 were retrieved. Their survival immune cell population circulatory blood compared among different types overall Results The 5-year...
The microRNA miR-187-3p plays antitumor roles in a variety of cancers. We and others have previously identified as potential tumor suppressor colorectal cancer (CRC), but there are also reports revealing that high levels associated with poor prognosis among CRC patients. This study further investigated the clinicopathological significance CRC.MiR-187-3p paired polyp/CRC/normal specimens or primary CRC/liver metastasis were determined by qPCR, correlated patient's postoperative survival data....
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases and its prevalence increasing worldwide. It reported that NAFLD associated with colorectal polyps. Since identifying in early stages could prevent possible progression to cirrhosis decrease risk HCC by intervention, patients polyp may thus be considered a target group for screening NAFLD. This study aimed investigate potential serum microRNAs (miRNAs) patients. Serum samples were collected from 141 patients,...
Recently the role of microRNAs has been explored immensely as novel regulators and potential biomarkers in several cancers. MiR-509-3p is one such miRNA that observed to show a mixed expression different cancers, while it's clinical relevance colorectal cancer (CRC) not yet characterized.We used quantitative PCR evaluate miR-509-3p fresh-frozen CRC tumor tissues corresponding tumor-adjacent normal (NAT) from 103 patients. Subsequently, functional studies were performed further interpret...
Abstract Screening plays a crucial role in the early detection of colorectal cancer, greatly reducing mortality rates. The objective this study was to identify non‐invasive diagnostic method utilizing serum microRNA expression for diagnosis cancer patients. consisted three stages. In first stage, 129 patients with and normal subjects were recruited as training set development blood miRNA panel. second stage involved recruiting 200 from each group validation cohort. Finally, blinded conducted...
Background: The dysregulation of gene expression is one the key molecular features colorectal cancer (CRC) development. This study aimed to investigate whether such reflected in rectal swab specimens CRC patients and evaluate its potential as a non-invasive approach for screening. Methods: We compared level 14 CRC-associated genes tumor adjacent non-tumor tissue examined correlation their levels with paired specimens. these was among or polyp control subjects, diagnostic each dysregulated...
Change in gene expression is inevitable cancer development. With more studies demonstrating the contributions of stem cells (CSCs) colorectal (CRC) development, this study aimed at investigating whether rectal swab specimen serves as a tool for detection dysregulation CSC or cell (SC) markers and evaluating its potential new promising screening method high-risk patients. Expression levels 15 pluripotency-associated genes were assessed by quantitative PCR 53 specimens referred endoscopic...
<h3>Background</h3> Colorectal cancer (CRC) has been one of the most common cancers worldwide. Without an early diagnosis, 5-year survival rate is drastically reduced when tumour reaches advanced stages. In addition to promoting detection, strategy for reducing CRC incidences develop effective non-invasive screening method targeting polyp, a potential precursor lesion CRC. To date, no test developed polyp identification with promising sensitivity. One novel biomarker microRNAs (miRNA), which...