A5008359819- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Maternal and fetal healthcare
- Birth, Development, and Health
- Tracheal and airway disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Coronary Artery Anomalies
- Renal and Vascular Pathologies
- Cytomegalovirus and herpesvirus research
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Vascular anomalies and interventions
- Parvovirus B19 Infection Studies
- Prenatal Screening and Diagnostics
- Cardiovascular Conditions and Treatments
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Ectopic Pregnancy Diagnosis and Management
- Connective tissue disorders research
- Gestational Diabetes Research and Management
Hospital Universitario 12 De Octubre
2012-2025
Spanish Clinical Research Network
2022-2024
Research Institute Hospital 12 de Octubre
2017-2023
Instituto de Salud Carlos III
2023
Universidad Complutense de Madrid
2011-2022
Fundación Instituto para la Mejora de la Asistencia Sanitaria
2022
Fundación General
2019
Cystic fibrosis (CF) is a potentially severe disease. The development of new therapies with cystic transmembrane conductance regulator (CFTR) modulators has been great advance in the management this condition because they improve function faulty CFTR protein rather than palliate its consequences. modulator therapy improves pancreatic and lung and, therefore, quality life, greater benefits sooner treatment started. For reason, use these being approved for increasingly younger patients. Only...
In Brief OBJECTIVE: To characterize the values of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio in pregnancies with fetal restriction or without concurrent preeclampsia hemolysis, elevated liver enzymes and low platelets syndrome (HELLP) normally grown fetuses HELLP. METHODS: This is a case–control study performed two centers (Berlin Madrid) consisting 171 singleton complicated by (n=27), HELLP (n=105) (n=39) pairwise matched gestational age healthy...
To determine which combination of cardiac parameters provides the best prediction postnatal coarctation aorta (CoAo) in fetuses with asymmetry.We selected all cases disproportion ventricles and great vessels prenatally diagnosed between 2003 2010 at Hospital Universitario '12 de Octubre', Madrid, Spain. Only appropriate-for-gestational age liveborn isolated asymmetry complete follow-up were included study. Eighty-five retrieved analyzed. Logistic regression analysis was used to select...
ABSTRACT Objective To describe the evolution of soluble fms‐like tyrosine kinase‐1 to placental growth factor (sFlt‐1/PlGF) ratio in last 5 weeks prior delivery singleton pregnancy complicated by early‐onset fetal restriction (FGR), with or without pre‐eclampsia (PE). Methods This was a prospective observational cohort study FGR cases that underwent serial assessment maternal serum sFlt‐1/PlGF from diagnosis delivery. Measurements were made at weekly intervals and within 48 h before birth....
ABSTRACT Objectives To determine which combination of cardiac parameters provides the best prenatal prediction coarctation aorta (CoAo). Methods We selected all cases simple asymmetry prenatally diagnosed in 2003–2013. Logistic regression was used to select predictors CoAo. Results The study population included 115 fetuses. CoAo confirmed 52 neonates (45%). sample divided two groups according gestational age (GA) at diagnosis: early group (EG) ≤28 weeks ( n = 57), and late (LG) >28 58)....
Abstract Objective To assess the value of a prediction model for pre‐eclampsia (PE) in first trimester (Ultrasound Obstet Gynecol 2007;30:742–794) late (>34 weeks) and early (≤34 PE high‐risk population. Methods Longitudinal study performed 152 pregnancies with at least one condition: previous PE, hypertension, pregestational diabetes, renal disease, obesity, hyperlipidemia, autoimmune disorders, thrombophilia or recurrent pregnancy loss. Mean uterine artery pulsatility index 11 to 13 + 6...
To evaluate the usefulness of mean pulsatility index uterine arteries (mPI-UtA) and automated measurement soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio on suspicion or at diagnosis pre-eclampsia (PE).Patients with singleton pregnancies PE (n = 60) diagnosed according to current recommendations, suspected 32) defined by (1) blood pressure (BP) ≥ 160/100 mmHg, (2) BP 140/90 mmHg proteinuria, together suggestive clinical symptoms (3) intrauterine restriction...
Abstract Objectives To determine which cardiac parameters provide the best prediction of postnatal outcome—biventricular (BV) versus non‐BV—in fetuses with pulmonary atresia/critical stenosis intact ventricular septum (PA/CS‐IVS). Methods We searched our database for cases PA/CS‐IVS prenatally diagnosed in 2001–2009. Only ⩽28 weeks were included. Data 16 (nine PA, seven CS) retrieved and analyzed. Receiver‐operating characteristics curves constructed to assess sensitivity specificity...
Fetal aortic valvuloplasty (FAV) may avoid progression of critical stenosis (CAS) to hypoplastic left ventricle, improving the options for biventricular circulation (BVC). We describe results FAV in 2 referral centers Spain.We analyzed all FAVs performed period 2007-2015. The selection candidates, technique, and postnatal management were made following an agreed protocol. A descriptive analysis survival, type after birth, complications was made, considering deaths first 48 h as...
<b><i>Objective:</i></b> To compare vaginal delivery rate and perinatal outcomes of fetuses with late-onset fetal growth restriction (FGR) undergoing labor induction, depending on the method for cervical ripening (dinoprostone vs. Foley balloon). <b><i>Material Methods:</i></b> We conducted a retrospective cohort study 148 consecutive singleton gestations diagnosed stage I FGR Bishop score &#x3c; 7, in which induction was indicated at ≥37 +...
Abstract Background As conflicting results have been reported about the association of reversed flow on aortic isthmus (AoI) and adverse perinatal in fetal growth restriction (FGR), we aim to compare outcomes (including tolerance labor induction) late-onset FGR between those with anterograde AoI flow. Methods This was an observational retrospective cohort study 148 singleton gestations diagnosed (diagnosis ≥32+0 weeks), estimated weight (EFW) <10 th centile mild Doppler alteration:...
Abstract Background Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances early diagnosis and postnatal management have increased survival CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, emerged as a key prognostic factor counseling of these pregnancies. Methods Eligible participants are women presenting at 20 to < 37 weeks gestation carrying fetus with CHD. Maternal/neonatal...
To assess the impact of prenatal diagnosis transposition great arteries (TGA) on postnatal outcome.Hundred and fifty-four patients with either simple (n = 101) or complex forms 53) TGA, diagnosed prenatally (G1, n 88) postnatally (G2, 66), who were admitted underwent surgical correction in our centre between 1998 2014, analysed.Prostaglandin E1 (PgE1) infusion balloon atrial septostomy (BAS) performed first 48 h after birth more commonly G1. The hospital mortality rate for whole group was...
To assess prospectively the capability of our previously reported global multiparameter scoring system to predict coarctation aorta (CoAo) in fetuses with cardiac asymmetry, we applied and analyzed performance predicting postnatal CoAo undergoing prenatal echocardiographic assessment because asymmetry between 2011 2021, determined cut-off points score best balance specificity sensitivity, maximum sensitivity specificity. was confirmed 39/179 newborns (21.8%). We found a significantly higher...
<b><i>Objective:</i></b> To compare perinatal outcomes on fetuses classified as stage I late-onset fetal growth restriction (FGR) depending the estimated weight (EFW) centile category and maternal Doppler study. <b><i>Material Methods:</i></b> Retrospective cohort study 131 cases of FGR (diagnosis ≥32<sup>+0</sup> weeks), defined as: EFW &#x3c; 3rd normal (G1) or 10th mean uterine artery pulsatility index (PI) &#x3e; 95th...
Objective: The aim of this work was to identify independent risk factors influencing the achievement vaginal delivery among women undergoing labor induction for late-onset fetal growth restriction (FGR). Methods: This a retrospective cohort study 201 singleton pregnancies with FGR (diagnosed >32 + 0 weeks) that required cervical ripening from 37 weeks, either dinoprostone (from 2014 2015) or Foley balloon 2016 2018). Independent successful were identified. A prediction model identified...
Introduction Prognostic markers for fetal transmission of Cytomegalovirus (CMV) infection during pregnancy are poorly understood. Maternal CMV-specific T-cell responses may help prevent and thus, we set out to assess whether this be the case in pregnant women who develop a primary CMV infection. Methods A multicenter prospective study was carried at 8 hospitals Spain, from January 2017 April 2020. Blood samples were collected time diagnosed response. Quantitative analysis interferon...
<b><i>Objectives:</i></b> Firstly, to describe the outcome of a series fetuses with Ebstein’s anomaly (EA) and, secondly, study utility different second-trimester echocardiographic parameters predict fetal and neonatal mortality. <b><i>Methods:</i></b> 39 EA diagnosed between 18 28 weeks gestation were included. Fetal echocardiography included cardiothoracic ratio (CTR); right atrial (RA) area index; displacement tricuspid valve (TV);...
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