A5002578953- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
- Blood groups and transfusion
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Diabetes and associated disorders
- Laser Applications in Dentistry and Medicine
- Transgenic Plants and Applications
- Hepatitis C virus research
- Endodontics and Root Canal Treatments
- Mosquito-borne diseases and control
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Oral microbiology and periodontitis research
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Perfectionism, Procrastination, Anxiety Studies
- Protein purification and stability
- Optimism, Hope, and Well-being
- Pharmacological Effects of Natural Compounds
- Hemoglobinopathies and Related Disorders
Najran University
2021-2024
King Khalid University
2013-2024
Huntington Medical Research Institutes
2024
Health Affairs
2024
Directorate of Health
2024
Shaqra University
2024
Universiti Sains Malaysia
2024
King Saud University
2021
University of Nottingham
2015
Antibiotic resistance (AR) is the mechanism pattern in bacteria that evolves over some time, thus protecting against antibiotics. AR due to bacterial evolution make itself fit changing environmental conditions a quest for survival of fittest. has emerged misuse and overuse antimicrobial drugs, few antibiotics are now left deal with these superbug infections. To combat AR, vaccination an effective method, used either therapeutically or prophylactically. In current study, silico approach was...
The coronavirus pandemic has affected more than 150 million people, while over 3.25 people have died from the disease 2019 (COVID-19). As there are no established therapies for COVID-19 treatment, drugs that inhibit viral replication a promising target; specifically, main protease (Mpro) process CoV-encoded polyproteins serves as an Achilles heel assembly of replication-transcription machinery well down-stream replication. In search potential antiviral target Mpro, series cembranoid...
To analyze hematological parameters for potential predictive markers of dengue. Blood samples were obtained from 146 individuals suspected having dengue at 2 hospitals in Jazan, Saudi Arabia. Control concurrently collected healthy adults (n=59). Samples screened anti-dengue antibodies by employing enzyme-linked immunosorbent assay. Hematological parameters, such as hemoglobin (HGB), white blood cells, hematocrit (HCT), platelets count, and red cells (RBCs) levels determined the positive all...
Type 2 diabetes mellitus [T2DM] has been one of the common diseases and is characterized by increased blood glucose levels suggested that cell-free non-coding RNAs microRNAs (miRNAs) have demonstrated to serve as important diagnostic/prognostic biomarkers in diabetes.The present study included clinically confirmed newly diagnosed 200 cases T2DM healthy subjects, all parameters were taken care diagnosis. Blood samples collected plain vials used for total RNA extraction after 100ng was...
<h3>Objectives:</h3> To explore the antibacterial activity of thymoquinone (TQ), a quinone extracted from <i>Nigella sativa</i>. <h3>Methods:</h3> This study was conducted May 2019 to March 2020 at Department Clinical Laboratory Sciences, College Applied Medical King Khalid University, Abha, Saudi Arabia. The antimicrobial activity, minimum inhibitory concentration (MIC), and bactericidal (MBC) TQ were determined using an agar well diffusion method broth microdilution assays, synergistic...
Walnuts are one of the healthiest foods in world because they best sources beneficial nutrients, minerals, and antioxidants. They also contain key energy. Despite several traditional uses, leaves Juglans regia L. have received little attention regarding phytochemical pharmacological potential. Thus, current study intended to find walnut genotypes with greatest antioxidant, anticancer, antifungal activity. The total polyphenolic, flavonoid, flavanol contents from 14 were determined. Genotypes...
The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Globally, this has affected over 111 million individuals and posed many health economic challenges. Much research effort dedicated to discovering new treatments address the associated challenges restrict spread of SARS-CoV-2. Since SARS-CoV-2 a positive-strand RNA virus, its replication requires viral RNA-dependent polymerase (RdRp) enzyme. In study, we report discovery...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to inflict chaos globally. emergence of a novel Omicron variant (B.1.1.529) in South Africa harbors 30 mutations the spike protein. is distinguished from other variants concern (VOCs) with an increased (15) number receptor-binding domain (RBD) and suggests higher chances causing reinfections. Initial reports also claimed that this escapes all neutralizing antibodies, thus demanding strategy against it. Thus,...
Abstract Background and aim Despite the fact that chikungunya viral infection is a neglected disease, complications such as hemorrhagic fever, arthritis, lymphopenia remain health concern. The of this study was to determine prevalence virus in Southern Region, Saudi Arabia. Enzyme immunoassay polymerase chain reaction have been compared between samples. Materials methods Forty samples from two southern hospitals Arabia were collected December 2019 February 2020 screened for IgG antibodies...
Background: Conserved domains within SARS-CoV-2 nonstructural proteins represent key targets for the design of novel inhibitors. Methods: The authors aimed to identify potential NSP5 inhibitors using ZINC database along with structure-based virtual screening and molecular dynamics simulation. Results: Of 13,840 compounds, 353 robust docking scores were initially chosen, which ten hit compounds selected as candidates detailed analyses. Three coronavirus after passing absorption, distribution,...
Hepatitis B virus (HBV), nowadays, is one of the major human pathogens worldwide. Approximately, 400 million people worldwide have chronic HBV infection. Only 5% persons infected during adulthood develop The reverse true for those at birth or in early childhood, i.e. more than 90% these progress to Currently, eight different genotypes o f been identified, differing nucleotide sequence by greater 8%. In addition, numerous subgenotypes a l s recognized based on variability 4- It has invariably...
Pneumocystis jirovecii (PCP) remains a significant cause of mortality and morbidity in patients with respiratory infections. Accurate diagnosis PCP is still diagnostic challenge. Hence, the main objectives were to study incidence Jirovecii pneumonia infection among problems compare real-time quantitative PCR technique various methodologies. Patients who have symptoms like breathlessness, cough, fever enrolled. Bronchoalveolar lavage (BAL) samples collected homogenized, then smears prepared...
Continuous urban developments have resulted in increased demand for street furniture, one of which is light columns. Artificial at night (ALAN) pose significant impacts on insect diversity and rural areas. The ALAN a driver decline diversity. This study evaluated the impact intensity sky quality areas Asir province, Saudi Arabia. Insect traps were installed both during night. Light nearby road lamps was measured using meter, while meter. Rural exhibited low (10.33 flux/f.candle) good (18.80...
The effects of the learning environment on academic performance can be investigated according to a broad range factors using diversity approaches. Many differences in have been associated with sex student. Objectives: This study aims understand impact absenteeism final grades earned by full-time medical laboratory sciences undergraduate students and whether this is affected sex. Academic was analyzed students' from two consecutive semesters (January April September December 2019). between...
Breast cancer is a heterogeneous disease in which genetic factors are involved worsening and higher mortality. Epidemiological clinical research revealed that breast incidence continues to rise. 100 histopathologically confirmed untreated newly diagnosed cases of invasive ductal carcinoma (IDC) healthy subjects were blood samples collected non-EDTA plain vials. Serum was separated by centrifugation, total RNA extracted from serum, cDNA synthesis done study the miRNA-495 neurexin-1 (NRXN-1)...
Background and Objectives: The aim of this study was to compare the effects low-level laser therapy continuous microwave diathermy on growth Gram-negative Gram-positive bacteria establish their efficacy as an alternative therapeutic modality.Laser fluence 13 Joules (J)/cm2, 18 J/cm2 30 were used against several bacterial strains. Microwave dosages 25, 50 100 watts (W) used, respectively.A significant difference between three groups observed using repeated analysis variance (RANOVA) (F value:...
This study is aimed at determining the seroprevalence and possible infectivity factors of human cytomegalovirus (HCMV) in children affected by type 1 diabetes mellitus (T1DM) Aseer Region KSA. A total 205 diagnosed with T1 DM who routinely attended Diabetic Centre (DC) Central Hospital (ACH) Abha KSA were randomly selected. Another control group 51 non-diabetic also Sera both groups tested for HCMV-specific IgG IgM using an indirect enzyme linked immune-sorbent assay (ELISA). The recorded...
Studies of risk factors are especially valuable at this difficult time in the midst a pandemic. High levels particulate matter (PM) represent serious factor on health. While is direct impact health, indirect effects worth considering, too.The aim study was to investigate role PM transmission viruses, SARS-CoV-2. Also, we sought understand dynamics still air high and low altitudes. Historic AQI physical measurements were collected between August September 2020 using quality detector....
Abstract Objectives: Peritoneal dialysis (PD) is a feasible option for patients with renal failure, but infectious peritonitis has long been common complication in PD. The purpose of the current study was to provide epidemiological data about rate, microbiology profile, and antimicrobial susceptibility pattern adult PD Saudi Arabia. Materials Methods: A descriptive performed. Demographics diagnostic between 2009 2019 were collected. episodes explained per patient profile along testing...