A5000779587- Cystic Fibrosis Research Advances
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Microfluidic and Bio-sensing Technologies
- Corneal Surgery and Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Polymer Synthesis and Characterization
- Asthma and respiratory diseases
- Phytochemical compounds biological activities
- Chemical Synthesis and Analysis
- Dendrimers and Hyperbranched Polymers
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neonatal Respiratory Health Research
- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Nematode management and characterization studies
- Antibiotic Resistance in Bacteria
- Hydrogels: synthesis, properties, applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- biodegradable polymer synthesis and properties
- ECG Monitoring and Analysis
- Polymer composites and self-healing
University of Córdoba
2020-2024
Instituto Maimónides de Investigación Biomédica de Córdoba
2020-2024
The University of Melbourne
2023
Universidad de Granada
2017-2021
Hospital Universitario Reina Sofía
2021
Instituto de Ciencia y Tecnología de Polímeros
2013-2019
Monash University
2016-2019
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2013-2019
Vertex Pharmaceuticals (United States)
2017
Australian Regenerative Medicine Institute
2017
Gelatin based adhesives have been used in the last decades different biomedical applications due to excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties mimic extracellular matrix (ECM). can be easily tuned gain viscoelastic that facilitate its ocular application. We herein grafted glycidyl methacrylate on gelatin backbone with a simple chemical modification of precursor, utilizing epoxide ring-opening reactions visible...
Abstract: Natural products using plants have received considerable attention because of their potential to treat various diseases. Arrabidaea chica (Humb. & Bonpl.) B. Verlot is a native tropical American vine with healing properties employed in folk medicine for wound healing, inflammation, and gastrointestinal colic. Applying nanotechnology plant extracts has revealed an advantageous strategy herbal drugs considering the numerous features that nanostructured systems offer, including...
The use of magnetic nanoparticles in hyperthermia, that is, heating induced by alternating fields, is gaining interest as a non-invasive, free side effects technique can be considered co-adjuvant other cancer treatments. Having sufficient control on the field characteristics, within admissible limits, focus presently material. In present contribution, no attempt has been made using composition than superparamagnetic iron oxide (SPION), or applying surface functionalization, which opens wider...
Magnetic nanoparticles (MNPs) have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by enhanced permeability and retention effect. Their incorporation into biopolymer coatings enables preparation magnetic field-responsive, biocompatible that are well dispersed in aqueous media. Here we describe a synthetic route prepare functionalized, stable magnetite coated with temperature-responsive polymer, means hydrothermal method combined...
Novel therapeutic approaches are urgently needed to combat nosocomial infections caused by extremely drug-resistant (XDR) "superbugs." This study aimed investigate the synergistic antibacterial activity of polymyxin B in combination with selective estrogen receptor modulators (SERMs) against problematic Gram-negative pathogens. In vitro and SERMs tamoxifen, raloxifene, toremifene was assessed using microdilution checkerboard static time-kill assays a panel isolates. Polymyxin were...
In this work a combined, multifunctional platform, which was devised for the simultaneous application of magnetic hyperthermia and delivery antitumor drug gemcitabine, is described tested in vitro. The system consists magnetite particles embedded polymer envelope, designed to make them biocompatible, thanks presence poly (ethylene glycol) shell. commercial particles, after thorough cleaning, are provided with carboxyl terminal groups, so that at physiological pH they present negative surface...
Ivacaftor–tezacaftor and ivacaftor–tezacaftor–elexacaftor are new breakthrough cystic fibrosis (CF) drug combinations that directly modulate the activity trafficking of defective CF transmembrane conductance regulator protein (CFTR) underlying disease state. Currently, in hospital setting, there no therapeutic monitoring assays for these very expensive, albeit, life-saving drugs. A rapid precise novel method quantification ivacaftor, its metabolites, tezacaftor, elexacaftor, human plasma was...
This article describes the synthesis of novel well defined polysaccharide–polymer bioconjugates. Alkyne-containing bioconjugates were prepared using Cu(I) catalyzed azide–alkyne [3 + 2] dipolar cycloaddition, i.e. 'click' chemistry between an alkyne functionalized low molecular weight heparin (LMWH) and α-azide stimuli-responsive copolymers synthesized by atom transfer radical polymerization Activators Generated Electron Transfer (AGET). The functionality was incorporated into conducting a...
Ivacaftor–lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of its metabolites hydroxymethylivacaftor (iva-M1) ivacaftorcarboxylate (iva-M6) with neurotransmitter receptors were investigated in radioligand binding assays. Ivacaftor displayed significant affinity to the 5-hydroxytryptamine (5-HT; serotonin) 5-HT 2C receptor (p K i =6.06±0.03), β 3 -adrenergic =5.71±0.07), δ-opioid =5.59±0.06) dopamine transporter...
In this paper, it is proposed that polymer-coated magnetic nanorods (MNRs) can be used with the advantage of a double objective: first, to serve as hyperthermia agents, and second, vehicles for antitumor drug doxorubicin (DOX). Two different synthetic methodologies (hydrothermal co-precipitation) were obtain MNRs maghemite magnetite. They coated poly(ethyleneimine) poly(sodium 4-styrenesulfonate), loaded DOX, using Layer-by-Layer technique. Evidence polymer coating loading was justified by...
Bemiparin (fractionated low molecular weight heparin)-loaded nanoparticles were prepared by two consecutive w/o emulsions and an inversion to o/w emulsion for various polymer systems as controlled release formulations. New synthetic block copolymers, poly(methyl methacrylate-b-trimethyl aminoethyl methacrylate) (PMMA-b-PMAETMA), with microstructure weight, RAFT (Reversible Addition-Fragmentation chain-Transfer) polymerization creating a set of polymers different amounts cationic charges. For...
Thermosensitive macroporous scaffolds of poly( N ‐isopropylacrylamide) (polyNIPA) loaded with chitosan/bemiparin nanoparticles are prepared by the free radical polymerization in cryogenic conditions. Chitosan/bemiparin 102 ± 6.5 nm diameter complex coacervation and into polyNIPA cryogels. SEM image reveal highly porous structure cryogels integration system. Volume phase transition temperature (VPT) total freezing water content established differential scanning calorimetry, their porosity is...
Magnetic nanoparticles have been largely applied to increase the efficacy of antibiotics due passive accumulation provided by enhancing permeability and retention, which is essential for treatment lung infections. Recurring infections such as in life-shortening genetic disease cystic fibrosis (CF) are a major problem. The recent advent CF modulator drug ivacaftor, alone or combination with lumacaftor tezacaftor, has enabled systemic majority patients. (MNPs) show unique properties...
The most common treatment for osteoarthritis is daily oral administration of a nonsteroidal anti-inflammatory drug such as diclofenac. This dosage regime often associated with severe side effects. In this study, we explored the potential utilizing high molecular weight cross-linked polyurethane polymer covalently linked to diclofenac (C-DCF-PU) intra-articular administration. We aim exploit advantages local delivery by developing an implant improved efficacy and reduced was synthesized from...