A5053591049- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune cells in cancer
- Children's Physical and Motor Development
- Obesity, Physical Activity, Diet
- Immune Response and Inflammation
- Physical Activity and Health
- Sirtuins and Resveratrol in Medicine
- Prostate Cancer Treatment and Research
- Tryptophan and brain disorders
- Gut microbiota and health
Auckland University of Technology
2022
Providence Portland Medical Center
2012-2014
Oregon Health & Science University
2013
Vaccine and Gene Therapy Institute
2013
Providence Regional Medical Center Everett
2013
Abstract OX40 is a potent costimulatory receptor that can potentiate T-cell signaling on the surface of T lymphocytes, leading to their activation by specifically recognized antigen. In particular, engagement ligands present dendritic cells dramatically increases proliferation, effector function, and survival cells. Preclinical studies have shown agonists increase antitumor immunity improve tumor-free survival. this study, we performed phase I clinical trial using mouse monoclonal antibody...
This article reports the methods and findings for Aotearoa New Zealand's 2022 Report Card on Physical Activity Children Youth indicators, inequities within these indicators.Grades were assigned to indicators using Active Healthy Kids Global Alliance criteria depending data availability, reported based gender, ethnicity, disability status, area-level socioeconomic deprivation, urbanicity, school year. Two additional included in this report card: Sleep, literacy.Grades as follows: Overall...
<h3>Background</h3> We examined the phenotype and function of lymphocytes collected from peripheral blood (PBL) tumor (TIL) patients with two different solid malignancies: colorectal cancer liver metastases (CRLM) ovarian (OVC). <h3>Methods</h3> Tumor corresponding were 16 CRLM 22 OVC patients; immediately following resection they processed analyzed using a multi-color flow cytometry panel. Cytokine mRNA purified PBL TIL CD4<sup>+</sup> T cells also by qPCR. <h3>Results</h3> Overall, we...
Meeting abstracts OX40, a member of the Tumor Necrosis Factor Receptor superfamily is potent co-stimulatory molecule. OX40 engagement increases T cell proliferation, effector function and survival. Pre-clinical studies have shown that agonist synergizes with radiation cyclophosphamide to
<h3>Background</h3> We examined the phenotype and function of lymphocytes collected from peripheral blood (PBL) tumor (TIL) patients with two different solid malignancies: colorectal cancer liver metastases (CRLM) ovarian (OVC). <h3>Methods</h3> Tumor corresponding were 16 CRLM 22 OVC patients; immediately following resection they processed analyzed using a multi-color flow cytometry panel. Cytokine mRNA purified PBL TIL CD4<sup>+</sup> T cells also by qPCR. <h3>Results</h3> Overall, we...
Abstract Characterizing TIL composition allows monitoring of immunotherapies and can be a prognostic factor for clinical outcome. Here we analyze the phenotype function lymphocytes collected from peripheral blood tumor infiltrating lymphocytes, immediately following resection, 15 patients with colorectal cancer liver metastases (CRLM) 21 ovarian primary tumors (OVC). Samples were analyzed using multi-color flow panel by qPCR cytokine production. The percentage different lymphocyte...
<p>PDF file - 198K, Figure 1. Characterization of the anti-OX40 mAb (9B12). 2. Total peripheral lymphocyte counts. 3. Pharmacokinetics CD134 (anti-OX40) in patients. 4. Direct ex vivo detection murine bound to T cells treated 5. Regression a pulmonary metastasis patient with renal carcinoma enrolled cohort 6. Changes Ki-67 expression within CD4+ and CD8+ cell subsets examined over time after from patients cohorts 1 7. Increased proliferation Foxp3- correlates decrease or stabilization...
<p>PDF file - 68K, Details clinical trial, flow cytometry and monkey experiments referred to in the manuscript.</p>
<p>PDF file - 198K, Figure 1. Characterization of the anti-OX40 mAb (9B12). 2. Total peripheral lymphocyte counts. 3. Pharmacokinetics CD134 (anti-OX40) in patients. 4. Direct ex vivo detection murine bound to T cells treated 5. Regression a pulmonary metastasis patient with renal carcinoma enrolled cohort 6. Changes Ki-67 expression within CD4+ and CD8+ cell subsets examined over time after from patients cohorts 1 7. Increased proliferation Foxp3- correlates decrease or stabilization...
<p>PDF file - 68K, Details clinical trial, flow cytometry and monkey experiments referred to in the manuscript.</p>
<div>Abstract<p>OX40 is a potent costimulatory receptor that can potentiate T-cell signaling on the surface of T lymphocytes, leading to their activation by specifically recognized antigen. In particular, OX40 engagement ligands present dendritic cells dramatically increases proliferation, effector function, and survival cells. Preclinical studies have shown agonists increase antitumor immunity improve tumor-free survival. this study, we performed phase I clinical trial using...
<div>Abstract<p>OX40 is a potent costimulatory receptor that can potentiate T-cell signaling on the surface of T lymphocytes, leading to their activation by specifically recognized antigen. In particular, OX40 engagement ligands present dendritic cells dramatically increases proliferation, effector function, and survival cells. Preclinical studies have shown agonists increase antitumor immunity improve tumor-free survival. this study, we performed phase I clinical trial using...
Abstract Age-related defects accumulate in both the innate and adaptive arms of immunity to generate a state immune deficiency. Our laboratory has previously shown decrease responses aged mice compared younger context OX40 costimulation. This loss during aging underscores need for simple approaches boost older individuals. We hypothesize that activation or blockade CTLA-4 can be restored and/or maintained through caloric restriction (CR) dietary supplementation with CR mimetic. Two regimens...