A5063786657- Chromosomal and Genetic Variations
- Pain Management and Opioid Use
- Histiocytic Disorders and Treatments
- Extracellular vesicles in disease
- Opioid Use Disorder Treatment
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Scientific Computing and Data Management
- Diet and metabolism studies
- Tumors and Oncological Cases
- interferon and immune responses
- Genetic and rare skin diseases.
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Genetics, Bioinformatics, and Biomedical Research
- Near-Field Optical Microscopy
- Sarcoma Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Data Analysis with R
- Gastrointestinal Tumor Research and Treatment
- Meta-analysis and systematic reviews
- RNA Interference and Gene Delivery
- Genetic Mapping and Diversity in Plants and Animals
Baylor College of Medicine
2019-2024
Texas Children's Hospital
2023
German Cancer Research Center
2020
Heidelberg University
2020
Abstract DNA in cells is supercoiled and constrained into loops this supercoiling looping influence every aspect of activity. We show here that negative transmits mechanical stress along the backbone to disrupt base pairing at specific distant sites. Cooperativity among sites localizes certain sequences superhelical apices. Base pair disruption allows sharp bending apices, which facilitates writhing relieve torsional strain. The coupling these processes may help prevent extensive...
In this study, we sought to create a database summarizing the expression of human endogenous retroviruses (HERVs) in various cancers. HERVs are suitable therapeutic targets due their abundance genome, overexpression malignancies, and involvement cancer pathways. We identified articles on from PubMed then prescreened automatically categorized them using portable document format (PDF) data extractor (PDE) R package. discovered 196 primary research with HERV tissues or cell lines. RNA protein...
Abstract We deployed the Blended Genome Exome (BGE), a DNA library blending approach that generates low pass whole genome (1-4x mean depth) and deep exome (30-40x data in single sequencing run. This technology is cost-effective, empowers most genomic discoveries possible with sequencing, provides an unbiased method to capture diversity of common SNP variation across globe. To evaluate this new at scale, we applied BGE sequence >53,000 samples from Populations Underrepresented Mental...
Sarcomas are relatively rare malignancies accounting for about 1% of all cancer diagnoses. Studies on sarcomas comprising large cohorts covering extended time periods lacking. Therefore, this study aimed to evaluate the impact demographic, behavioral, and clinical characteristics overall survival (OS) among individuals diagnosed with soft tissue sarcoma (STS) or bone at Moffitt Cancer Center between 1986 2014. Unadjusted multivariable Cox proportional hazard regression (CPHR) models were...
In addition to regulatory or accessory proteins, some complex retroviruses gain a repertoire of micro-RNAs (miRNAs) regulate and control virus–host interactions for efficient replication spread. particular, bovine simian foamy viruses (BFV SFV) have recently been shown express diverse set RNA polymerase III-directed miRNAs, with unique primary miRNA double-hairpin, dumbbell-shaped structure not known in other organisms. While the mechanisms expression structural requirements studied,...
This study aims to introduce the OralOpioids R package, a novel research tool for in-depth and analysis of opioid prescriptions in Canada, which reports significant per-capita pharmaceutical consumption.The package employs data from Health Canada's Drug Product Database (DPD), focusing on authorized oral opioids. It systematically filters drug identification numbers (DINs) by narcotic schedules administration routes. Moreover, it calculates morphine equivalent dose (MED) each DIN using CDC...
<ns3:p>Background The goal of the Fifth Annual Baylor College Medicine & DNAnexus Structural Variation Hackathon was to push forward research on structural variants (SVs) by rapidly developing and deploying open-source software. event took place in-person virtually in August 2023, when 49 scientists from 14 countries 8 U.S. states collaboratively worked projects address critical gaps field genomics. hackathon concentrated bioinformatic workflows for following challenges: RNA...
Background: The opioid crisis remains a significant public health challenge in North America, highlighted by the substantial need for tools to analyze and understand potency prescription patterns. Methods: OralOpioids package automates retrieval, processing, analysis of data from Health Canada’s Drug Product Database (DPD) U.S. Food Administration’s (FDA) National Code (NDC) database. It includes functions such as load_Opioid_Table, which integrates country-specific processing Morphine...
Papillary thyroid cancer (PTC) is one of the fastest-growing cancers worldwide, lacking established causal factors or validated early diagnostics. Human endogenous retroviruses (HERVs), comprising 8% human genomes, have potential as PTC biomarkers due to their comparably high baseline expression in healthy tissues, indicating homeostatic roles. However, HERV regions are often overlooked genome-wide association studies because highly repetitive nature, low sequence coverage, and decreased...
Literature reviews are generally time-consuming and rely heavily on accurate representation of the data in title abstract articles. Often minor results details lost a systematic screen, which is becoming even more frequent with rapidly rising numbers daily published scientific We developed PDF Data Extractor (PDE) R package to aid scientists at any stage literature while offering user-friendly interface. The tool permits user categorize large full-text articles format, export containing...
Abstract Background: Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by lesions including pathogenic CD207+ dendritic cells among infiltrate with recurrent, mutually exclusive somatic activating mutations in MAPK pathway genes ~85% of LCH lesions; however, germline risk factors remain largely unknown. A SEER analysis reported that incidence high-risk was higher Hispanic populations than non-Hispanic populations, and lowest Black populations. Our group...