A5039722670- Migraine and Headache Studies
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Biochemical effects in animals
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Nicotinic Acetylcholine Receptors Study
- Salivary Gland Disorders and Functions
- Neuropeptides and Animal Physiology
- Gut microbiota and health
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Trigeminal Neuralgia and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Bipolar Disorder and Treatment
- Pain Mechanisms and Treatments
- Adenosine and Purinergic Signaling
University of Szeged
2015-2025
MTA-SZTE Research Group on Artificial Intelligence
2017-2018
The intestinal flora has been the focus of numerous investigations recently, with inquiries not just into gastrointestinal aspects but also pathomechanism other diseases such as nervous system disorders and mitochondrial diseases. Mitochondrial are most common type inheritable metabolic illness caused by mutations nuclear DNA. Despite intensive research, its diagnosis is usually difficult, unfortunately, treating it challenges physicians. Metabolites kynurenine pathway linked to many...
Abstract Background The topical inflammatory soup can model the inflammation of dura mater causing hypersensitivity and activation trigeminal system, a phenomenon present in migraineurs. Calcitonin gene-related peptide, transient receptor potential vanilloid-1 receptor, neuronal nitric oxide synthase are important sensitization process there. 5-HT 1B/1D agonists, triptans used as treatment migraine. Kynurenic acid an NMDA antagonist act on structures involved activation. Aim We investigated...
One of the human and animal models migraine is systemic administration nitric oxide donor (NO) nitroglycerin (NTG). NO can provoke migraine-like attacks in migraineurs initiates a self-amplifying process trigeminal system, probably leading to central sensitization. Recent studies suggest that endocannabinoid system involved nociceptive signal processing cannabinoid receptor (CB) agonists are able attenuate nociception pain.The purpose present study was investigate modulatory effects CB...
Migraines are a frequently occurring neurological condition that affects up to 16% of the global population. The precise pathomechanism disease remains unknown, but from animal and human observations, it appears calcium/calmodulin-dependent protein kinase II alpha (CamKIIα), pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal (VIP) involved in its pathogenesis. One models migraines uses systemic administration nitroglycerin (NTG), which, as nitric oxide (NO)...
The primary headache disorders include migraine, which is one of the most frequent neurological disorders, influences more than 14% whole population. Despite research efforts, its exact pathomechanism not fully revealed, but evidence points to role glutamate and receptors. Kynurenic acid an endogenous receptor antagonist produced by kynurenine pathway (KP). Tryptophan 2,3-dioxygenase (TDO) indoleamine (IDO) convert l-tryptophan N-formyl-l-kynurenine, be further transformed l-kynurenine....
Migraine, recognized as a severe headache disorder, is widely prevalent, significantly impacting the quality of life for those affected. This article aims to provide comprehensive review application animal model technologies in unraveling pathomechanism migraine and developing more effective therapies. It introduces variety experimental models used research, emphasizing their versatility importance simulating various aspects condition. details benefits arising from utilization these models,...
Although migraine is one of the most common primary headaches, its therapy still limited in many cases. The use animal models crucial development novel therapeutic strategies, but unfortunately, none them show all aspects disease, therefore, there a constant need for further improvement this field. application inflammatory agents on dura mater widely accepted method to mimic neurogenic inflammation rodents, which plays key role pathomechanism migraine. Complete Freund's Adjuvant (CFA), and...
Probenecid has been widely used in the treatment of gout, but evidence suggests that it may also have antinociceptive effects different inflammatory and pain conditions. We examined potential modulatory probenecid on behavioural morphological markers orofacial formalin test rat. One hour after pre-treatment with vehicle or (1 mmol/kg body weight) intraperitoneally, 50μl 1.5% solution physiological saline was injected subcutaneously into right whisker pad rats. The rubbing activity directed...
Kynurenic acid (KYNA) is one of the most significant metabolite kynurenine pathway both in terms functional and potential therapeutic value. It an N-methyl-D-aspartate (NMDA) receptor antagonist, but it can also activate G-protein coupled 35 (GPR35), which shares several structural properties with cannabinoid receptors. Previously our group demonstrated that systemic chronic KYNA treatment altered opioid activity. Opioid receptors overlap many features Thus, aim was to examine direct vitro...
The prevalence of craniofacial pain disorders show sexual dimorphism with generally more common appearance in women suggesting the influence estradiol, but exact cause remains unknown. point pathogenesis these is activation trigeminal system. One animal experimental models orofacial formalin test, which we investigated effect chronic 17β-estradiol pretreatment on pain-related behavior and second-order neurons at level spinal nucleus pars caudalis (TNC).Female Sprague Dawley rats were...