A5025037519- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Physiological and biochemical adaptations
- Invertebrate Immune Response Mechanisms
- Circadian rhythm and melatonin
- Axon Guidance and Neuronal Signaling
- Plant and Biological Electrophysiology Studies
- Ion Channels and Receptors
- Hippo pathway signaling and YAP/TAZ
- Insect Utilization and Effects
- Developmental Biology and Gene Regulation
- Insect Resistance and Genetics
- Plant and animal studies
- Photoreceptor and optogenetics research
- Bacterial Genetics and Biotechnology
- Skin and Cellular Biology Research
- Enzyme Production and Characterization
- Retinal Development and Disorders
- Plant Molecular Biology Research
- Insect Pest Control Strategies
- Insect behavior and control techniques
- Plant Reproductive Biology
- Animal Behavior and Reproduction
- Wound Healing and Treatments
- Biochemical Analysis and Sensing Techniques
Northwestern University
2015-2025
Howard Hughes Medical Institute
2011-2014
Columbia University
2011-2014
University of California, San Diego
2009-2011
Stockholm University
2004-2009
Wenner-Gren Foundations
2004-2009
Karolinska Institutet
2000-2004
Södertörn University
2000-2004
Case Western Reserve University
2002
Abstract Determining the pattern of activity individual connections within a neural circuit could provide insights into computational processes that underlie brain function. Here, we develop new strategies to label active synapses by trans-synaptic fluorescence complementation in Drosophila . First, demonstrate synaptobrevin-GRASP chimera functions as powerful activity-dependent marker for vivo Next, create cyan and yellow variants, achieving activity-dependent, multi-colour reconstitution...
Catnip (Nepeta cataria) is a common garden herb well known for its euphoric and hallucinogenic effects on domestic cats,1-3 medicinal properties,4,5 as powerful repellent action insects.6,7 extracts have been proposed natural alternative to synthetic insect repellents, such N,N-diethyl-3-methylbenzamide (DEET),8,9 but how catnip triggers aversion in insects not known. Here, we show that, both Drosophila melanogaster flies Aedes aegypti mosquitoes, the major mediator of repellency widely...
Slit proteins steer the migration of many cell types through their binding to Robo receptors, but how controls motility is not clear. We describe functional analysis vilse , a Drosophila gene required for repulsion in epithelial cells and axons. Vilse defines conserved family RhoGAPs (Rho GTPase-activating proteins), with representatives flies vertebrates. The phenotypes mutants resemble tracheal axonal at CNS midline. Dosage-sensitive genetic interactions between vilse, slit robo suggest...
Epidermal growth factor receptor (EGFr) is a key mediator of cell communication during animal development and homeostasis. In Drosophila , the signaling event commonly regulated by polytopic membrane protein Rhomboid (RHO), which mediates proteolytic activation EGFr ligands, allowing secretion active signal. Until very recently, biochemical function RHO had remained elusive. It now believed that founder member previously undescribed family serine proteases, it could be directly responsible...
Abstract Simple innate behavior is often described as hard-wired and largely inflexible. Here, we show that the avoidance of hot temperature, a simple behavior, contains unexpected plasticity in Drosophila . First, demonstrate receptor neurons antenna their molecular heat sensor, Gr28B.d, are essential for flies to produce escape turns away from heat. High-resolution fly tracking combined with 3D simulation thermal environment shows that, steep gradients, direction determined by minute...
EGF-receptor ligands act as chemoattractants for migrating epithelial cells during organogenesis and wound healing. We present evidence that Rhomboid 3/EGF signalling, which originates from the midline of Drosophila ventral nerve cord, repels tracheal ganglionic branches prevents them crossing it. rho3 acts independently main repellent Slit, a different sub-population cells: VUM neurons. Expression dominant-negative Egfr or Ras induces crosses, whereas activation in leading cell branch can...
Abstract Neurons that participate in sensory processing often display “ON” responses, i.e., fire transiently at the onset of a stimulus. ON transients are widespread, perhaps universal to coding, yet their function is not always well-understood. Here, we show responses Drosophila thermosensory system extrapolate trajectory temperature change, priming escape behavior if unsafe thermal conditions imminent. First, second-order projection neurons (TPN-IIIs) and Lateral Horn targets (TLHONs),...
SUMMARY Neurons that participate in sensory processing often display “ON” responses, i.e. fire transiently at the onset of a stimulus. ON transients are widespread, perhaps universal to coding, yet their function is not always well-understood. Here, we show responses Drosophila thermosensory system extrapolate trajectory temperature change, priming escape behavior if unsafe thermal conditions imminent. First, second-order projection neurons (TPN-IIIs) and Lateral Horn targets (TLHONs),...
All animals must detect noxious stimuli to initiate protective behavior, but the evolutionary origin of nociceptive systems is not well understood. Here, we show that a remarkably conserved signaling mechanism mediates detection in as diverse flatworms and humans. Planarian are amongst simplest bilateral with centralized nervous system, capable directed behavior. We demonstrate heat irritant chemicals elicit robust escape behaviors planarian Schmidtea mediterranea , ion channel TRPA1...