Abstract There is evidence that aerobic exercise improves brain health. Benefits may be modulated by acute physiological responses to exercise, but this has not been well characterized in older or cognitively impaired adults. The randomized controlled trial ‘AEROBIC’ (NCT04299308) enrolled 60 adults who were healthy ( n = 30) characterize the moderate [45–55% heart rate reserve (HRR)] and higher (65–75% HRR) intensity exercise. Each participant received two fluorodeoxyglucose positron...

Oxygenated lipids, called "oxylipins," serve a variety of important signaling roles within the cell. Oxylipins have been linked to inflammation and vascular function, blood patterns shown differ in type 2 diabetes (T2D). Because these factors (inflammation, diabetes) are also associated with Alzheimer's disease (AD) risk, we set out characterize serum oxylipin profile elderly AD subjects understand if there shared between T2D. We obtained from 126 well-characterized, overnight-fasted...

Alzheimer's Disease (ad) associates with insulin resistance and low aerobic capacity, suggestive of impaired skeletal muscle mitochondrial function. However, this has not been directly measured in AD. This study ( n = 50) compared respiratory function gene expression profiling cognitively healthy older adults (CH; 24) to 26 individuals the earliest phase ad-related cognitive decline, mild impairment (MCI; 11) or MCI taking ad medication donepezil (MCI + med; 15). Mitochondrial kinetics were...

Background: The development of biomarkers that are easy to collect, process, and store is a major goal research on current Alzheimer’s Disease (AD) underlies the growing interest in plasma biomarkers. Biomarkers with these qualities will improve diagnosis allow for better monitoring therapeutic interventions. However, blood collection strategies have historically differed between studies. We examined ability various ultrasensitive predict cerebral amyloid status cognitively unimpaired...

Over the course of aging, there is an early degradation cerebrovascular health, which may be attenuated with aerobic exercise training. Yet, acute response to a single bout remains elusive, particularly within key brain regions most affected by age-related disease processes. We investigated global and region-specific cerebral blood flow (CBF) 15 minutes moderate-intensity in older adults (≥65 years; n = 60) using arterial spin labeling magnetic resonance imaging. Within 0-6 min...

There is evidence that aerobic exercise beneficial for brain health, but these effects are variable between individuals and the underlying mechanisms modulate benefits remain unclear.

First-degree relatives of individuals with late-onset Alzheimer's disease (AD) have increased risk for AD, children affected parents at an especially high risk.We aimed to investigate default mode network connectivity, medial temporal cortex volume, and cognition in cognitively healthy (CH) (FH+) without (FH-) a family history alongside amnestic mild cognitive impairment (aMCI) AD individuals, determine the context directionality dysfunction at-risk individuals. Our primary hypothesis was...

Objective: To test the validity of a common measure health-related quality life (Short-Form-36 [SF-36]) in cognitively healthy older adults living rural and urban Costa Rica. Method: Confirmatory factor analysis was applied to SF-36 data collected 250 from San Jose Guanacaste, Results: The best fitting model for an eight first-order structure. A high correlation between Mental Component Summary Physical scores found. Region differences indicated that dwellers perceive poorer compared with...

Individuals with Alzheimer's Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects AD on other relevant metabolic hormones, such as incretins that affect secretion and food intake, remains less clear.Here, we leveraged a physiologically meal tolerance test to assess diagnostic differences in these responses cognitively healthy older adults (CH; n = 32) (n 23) participants. All individuals also underwent comprehensive clinical...

Abstract Background States of altered metabolic health such as syndrome (MetS), obesity, and insulin resistance increase Alzheimer’s Disease (AD) risk. Individuals with these conditions, like those AD, have demonstrated changes in the structural functional features Default Mode Network (DMN). Here, we characterize associations between systemic dysfunction, brain structure (Cortical Thickness Hippocampal Volume) connectivity DMN subnetworks. Method We leveraged data from Health Aging Brain...

Abstract Background Aerobic exercise may positively affect brain health, although relationships with cognitive change are mixed. This likely is due to individual differences in the systemic physiological response exercise. However, acute effects of on metabolism and biomarker responses not well characterized older adults or cognitively impaired individuals. Method The Acute Exercise Response Brain Imaging Cognition (AEROBIC) study a randomized, controlled trial (NCT04299308). We enrolled...

Abstract Background States of altered metabolic health such as syndrome (MetS), obesity, and insulin resistance increase Alzheimer’s Disease (AD) risk. Individuals with these conditions, like those AD, have demonstrated changes in the structural functional features Default Mode Network (DMN). Here, we characterize associations between systemic dysfunction, brain structure (Cortical Thickness Hippocampal Volume) connectivity DMN subnetworks. Method We leveraged data from Health Aging Brain...

Abstract Over the course of aging, there is an early degradation cerebrovascular health that may be attenuated with aerobic exercise training. Yet, acute response to a single bout remains elusive, particularly within key brain regions most affected by age-related disease processes. We investigated global and region-specific cerebral blood flow (CBF) 15 minutes moderate-intensity in older adults (≥65years) (n=60) using arterial spin labeling magnetic resonance imaging. Within 0-6...

Abstract Background T 2 ‐Relaxation‐Under‐Spin‐Tagging (TRUST) is an MRI technique which allows for the measurement of brain blood oxygenation. Global venous oxygenation has been shown to decrease over course life and may prove useful as a measure aging. No studies date have examined association between cardiovascular fitness Method (Y v ) cardiorespiratory were measured in sixteen older adults. Y was from voxels within superior sagittal sinus (SSS) using TRUST sequence. The four with...

Abstract Background First‐degree relatives of individuals with late‐onset Alzheimer’s Disease (AD) have increased risk for AD, children affected parents at an especially high risk. We sought to test how structural or functional abnormalities in the default mode network (DMN) during brain’s “resting state” characterized AD. Method used MRI and fMRI study cognitively healthy (n=28) without AD family history (FH+ FH‐, respecitvely), those amnestic mild cognitive impairment (aMCI; n=31)...

Abstract Background Alzheimer’s Disease (AD) pathology in vivo has traditionally been measured the cerebrospinal fluid or by positron emission tomography (PET). Developments measuring plasma biomarkers present less invasive, cheaper ways to quantify AD pathology. However, associations between these new markers and neuroimaging of are not fully understood. We examined relationship measures whole brain gray matter volume (GMV) cerebral glucose metabolism both cognitively unimpaired (n = 83)...

The Short-Form Health Survey (SF-36) is a self-administered questionnaire that consists of physical health component cluster and mental (Ware Kosinski, 2001). Research using Spanish version the SF-36 instrument have been conducted in Spanish-speaking countries (Augustovski et al., 2008), however, applicability has not examined Costa Ricans. Given heterogeneity sociocultural differences among Latin America, we aim to examine perception health-related quality life sample neurotypical older...

Abstract Background: The development of biomarkers that are easy to collect, process, and store is a major goal current Alzheimer’s Disease (AD) research, underlies the growing interest in plasma biomarkers. Biomarkers with these qualities will improve confidence diagnosis allow for better monitoring therapeutic interventions. However, blood collection strategies have historically differed between studies. We examined ability various ultrasensitive predict cerebral amyloid status cognitively...

Abstract Background Accumulating evidence suggests that Alzheimer’s Disease (AD) plasma biomarkers aid in screening for at‐risk individuals, tracking disease progression, and monitoring response to interventions. Plasma amyloid‐β (Aβ) phosphorylated tau (pTau) have shown promise predicting cerebral deposition of Aβ, while neurofilament light chain (NfL) serves as a more global marker neurodegeneration. However, blood collection protocols often differ, it is important confirm the relationship...

Abstract Background Insulin resistance is a known risk factor for Alzheimer’s Disease and related dementias (ADRD). While the role of insulin on peripheral tissue well understood, it’s effect brain remains unclear. other gastrointestinal peptides can cross blood‐brain barrier to form ligands in areas involved metabolic response. Thus, important understand relationship between systemic outcomes, such as meal‐stimulated hormone responses, plasma biomarkers ADRD. Method 67 Participants (27...

Abstract Background There is evidence that aerobic exercise beneficial to the brain and may reduce risk for cognitive decline dementia. However, clinical trials have shown benefits of programs vary amongst individuals. This variability occur in part due differences physiological biomarker response acute exercise. Characteristics such as age, sex, apolipoprotein E4 (APOE4) genotype affect these responses, but blood processing protocols introduce additional into measures. Method We...