A5044788478- Neuroscience and Neuropharmacology Research
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Nuclear Receptors and Signaling
- Protein Tyrosine Phosphatases
- Redox biology and oxidative stress
- ATP Synthase and ATPases Research
Tongji University
2019-2023
The accurate expression of postsynaptic AMPA receptors (AMPARs) is critical for information processing in the brain, and ubiquitination a key regulator this biological process. However, roles E3 ubiquitin ligases regulation AMPARs are poorly understood. Here, we find that RNF220 directly interacts with to meditate their polyubiquitination, knockout specifically increases AMPAR protein levels, thereby enhancing basal synaptic activity while impairing plasticity. Moreover, depending on its...
Abstract The retrosplenial cortex (Rsp) is a transitional located between the neocortex and archicortex, but molecular mechanism specifying Rsp from archicortex remains elusive. We here report that transcription factor Satb2 required for identity during its morphogenesis. In CKO mice, boundary [i.e., subiculum (SubC)] disappears as early E17.5, efferent projection aberrant. Rsp-specific genes are lost, whereas SubC-specific ectopically expressed in of mice. Furthermore, cell-autonomous role...
Noradrenaline belongs to the monoamine system and is involved in cognition emotional behaviors. Phox2a Phox2b play essential but non-redundant roles during development of locus coeruleus (LC), main noradrenergic (NA) neuron center mammalian brain. The ubiquitin E3 ligase Rnf220 its cofactor Zc4h2 participate ventral neural tube patterning by modulating Shh/Gli signaling,
Abstract To establish functional circuitry, neurons settle down in a particular spatial domain by spacing their cell bodies, which requires proper positioning of the soma and establishing zone with unique connections. Deficits this process are implicated neurodevelopmental diseases. In study, we examined function EphB6 development cerebral cortex. Overexpression via utero electroporation results clumping cortical neurons, while reducing its expression has no effect. addition, overexpression...
Soma spacing and dendritic arborization during brain development are key events for the establishment of proper neural circuitry function. Transcription factor Satb2 is a molecular node in regulating cerebral cortex, as shown by facts that required regionalization retrosplenial determination callosal neuron fate, regulation soma self-avoidance cortical pyramidal neurons. In this study, we explored downstream effectors mediate Satb2-implicated self-avoidance. First, RNA-seq analysis cortex...
Despite of strenuous research in the past decades, etiology schizophrenia (SCZ) still remains incredibly controversial. Previous genetic analysis has uncovered a close association Unc-51 like kinase 4 (ULK4), family member Unc-51-like serine/threonine kinase, with SCZ. However, animal behavior data which may connect Ulk4 deficiency psychiatric disorders, particularly SCZ are missing.We generated Emx1-Cre:Ulk4flox/flox conditional knockout (CKO) mice, was deleted excitatory neurons cerebral...