A5030927057- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Muscle metabolism and nutrition
- Metabolomics and Mass Spectrometry Studies
- Clinical Nutrition and Gastroenterology
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
- Dietary Effects on Health
- Cancer, Hypoxia, and Metabolism
- Regulation of Appetite and Obesity
- Mitochondrial Function and Pathology
Universitat de Barcelona
2014-2016
Faculty (United Kingdom)
2015-2016
FC Barcelona
2015-2016
Institute for Research in Biomedicine
2014
White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially obesity;Under normoxia, 3T3L1 cells secrete large quantities of to the medium, again at expense glucose and proportionally its levels. Most was converted with only part it being used synthesize fat. Cultured adipocytes were largely anaerobic, but this not a Warburg-like process. It is speculated that massive production lactate, process defense adipocyte, dispose excess glucose. This way,...
Female and male adult Wistar rats were fed standard chow or a simplified cafeteria diet for one month. Then, the killed white adipose tissue (WAT) in four sites: perigonadal, retroperitoneal, mesenteric subcutaneous (inguinal) sampled frozen. The complete WAT weight each site was measured. Gene expression analysis of key lipid glucose metabolism enzymes analyzed, as well plasma lactate activity dehydrogenase. Lactate gradients between estimated. influence sex (and indirectly mass) on levels...
Hyperlipidic diets limit glucose oxidation and favor amino acid preservation, hampering the elimination of excess dietary nitrogen catabolic utilization acids. We analyzed whether reduced urea excretion was a consequence higher NO x ; (nitrite, nitrate, other derivatives) availability caused by increased nitric oxide production in metabolic syndrome. Rats fed cafeteria diet for 30 days had intake accumulation lower excretion. There were no differences plasma nitrate or nitrite. NO(x)...
White adipose tissue urea-cycle enzymes showed a high activity and gene expression, second only to liver in catalytic capacity.
Background and Objectives. White adipose tissue (WAT) shows marked sex- diet-dependent differences. However, our metabolic knowledge of WAT, especially on amino acid metabolism, is considerably limited. In the present study, we compared influence sex metabolism profile four main WAT sites, focused paths related to ammonium handling urea cycle, as a way estimate extent implication body amino-nitrogen metabolism. Experimental Design. Adult female male rats were maintained, undisturbed, under...
Liver amino acid metabolism decreased with cafeteria diet through lower ammonium production (even in females) and urea cycle activity.
Background and objectives. Red blood cells (RBC) are continuously exposed to oxidative agents, affecting their membrane lipid function. However, the amount of in RBCs is higher than lipids cell membrane, includes triacylglycerols, which no components. We assumed that extra originated from lipoproteins attached surface, we intended analyse whether size composition this pool were affected by sex or diet. Experimental design. Adult male female Wistar rats fed control cafeteria diets. Packed...
Under high-energy diets, amino acid N is difficult to dispose of, as a consequence of the availability alternative substrates.
Background. A “cafeteria” diet is a self-selected high-fat diet, providing an excess of energy, which can induce obesity. Excess lipids in the hampers glucose utilization eliciting insulin resistance, which, further limits amino acid oxidation for energy. Methods. Male Wistar rats were exposed month to diet. Rats cannulated and fluorescent microspheres used determine blood flow. Results. Exposure cafeteria did not change cardiac output, but there was marked shift organ irrigation. Skin flow...