A5010989809- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacovigilance and Adverse Drug Reactions
- Hormonal Regulation and Hypertension
- Autoimmune Neurological Disorders and Treatments
- Treatment of Major Depression
- Erythrocyte Function and Pathophysiology
- Microbial Natural Products and Biosynthesis
- Neurotransmitter Receptor Influence on Behavior
- Electroconvulsive Therapy Studies
- Pharmaceutical Practices and Patient Outcomes
- Stress Responses and Cortisol
- Neonatal Health and Biochemistry
- Biosimilars and Bioanalytical Methods
- Genetics and Neurodevelopmental Disorders
- Pharmacy and Medical Practices
- Pathogenesis and Treatment of Hiccups
- Cellular transport and secretion
- Mental Health Research Topics
- Nitric Oxide and Endothelin Effects
- Signaling Pathways in Disease
- Reproductive biology and impacts on aquatic species
- Sarcoidosis and Beryllium Toxicity Research
- Alkaloids: synthesis and pharmacology
- Liver Disease Diagnosis and Treatment
Kitasato University
2018-2025
The University of Tokyo
1988-2024
Sapporo City General Hospital
2023
National Institute for Physiological Sciences
2021-2022
National Institutes of Natural Sciences
2021-2022
Pfizer (Japan)
2016-2020
Ibero American University
2020
University of Fukui Hospital
2017
Enoshima Aquarium
2003
Gunma University
1982-1984
Significance This study addresses a fundamental question in neuroscience, namely how does the presynaptic component of synapse precisely align with postsynaptic component? is essential for proper transmission signals across synapse. paper focuses on set transsynaptic, epilepsy-related proteins that are this alignment. We show LGI1–ADAM22–MAGUK complex key player nanoarchitecture synapse, such release site directly apposed to nanocluster glutamate receptors.
The in vivo binding of clinical dose venlafaxine on norepinephrine transporter has been questioned because higher vitro affinity to serotonin than that transporter. Although occupancy clinically relevant doses reported, there no report the human brain. This was an open-label, single center, exploratory positron emission tomography study. Twelve major depressive disorder patients who had responded extended-release and 9 control subjects were recruited. Each subject participated one...
Abstract The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical investigation approach was employed NP exploration using the genus Paraconiothyrium sp. isolated root soil Ficus microcarpa on Noho Island, Okinawa. Consequently, we five compounds, including new chromone, nohocumone ( 1 ), as well four known chromone 2 10‐norparvulenone 3 sclerotinin A 4 and calbistrin 5 culture broth FKR‐0637. planar...
Abstract Pathogenic variants in A Disintegrin And Metalloproteinase (ADAM) 22, the postsynaptic cell membrane receptor for glycoprotein leucine-rich repeat glioma-inactivated protein 1 (LGI1), have been recently associated with recessive developmental and epileptic encephalopathy. However, so far, only two affected individuals described many features of this disorder are unknown. We refine phenotype report 19 additional harbouring compound heterozygous or homozygous inactivating ADAM22...
Abstract Lichen planus is a chronic T‐cell‐mediated disorder in which lymphocytes, including Th17 cells, react toward the dermo‐epidermal junction, shows interface changes. Recently, IL‐17‐mediated changes oral mycobiome, proliferation of Candida and Aspergillus fungi, have been proposed as possible pathomechanism lichen (OLP). We treated 54‐year‐old male who had suffering from psoriatic arthritis. Secukinumab rapidly improved skin joint symptoms, but painful erosion on lip thrush buccal...
Abstract We report the case of a 9‐year‐old girl who presented with mixed‐type fulminant autoimmune hemolytic anemia (AIHA) at onset systemic lupus erythematosus (SLE). On admission, laboratory investigations indicated very severe (Hb, 2.7 g/dL) reticulocytosis and positive direct/indirect Coombs tests. In addition, agglutinative reaction was clinically observed. Based on further examinations, patient diagnosed AIHA complicated SLE, identified. With oral prednisolone methylprednisolone pulse...
Plasma volume (PV) and extracellular fluid (ECF) were determined in 7 patients with essential hypertension (controls) 10 primary aldosteronism, while on a high Na diet (342 mEq/day) low (12 mEq/day). The studies repeated 6 of the aldosteronism during treatment spironolactone for over 3 months. renin activity (PRA), plasma aldosterone concentration (PAC), cortisol concentration, serum K concentrations measured all Na-restricted (85 as well high-Na low-Na diets. There no significant changes...
PurposeAn all-case, single-arm, observational, postmarketing surveillance is underway to assess the safety of tafamidis in patients with hereditary transthyretin (ATTRv) amyloidosis peripheral polyneuropathy, also called transthyretin-type familial amyloid Japan. Results from an interim analysis (data cutoff date, May 15, 2018) are presented this preliminary report.MethodsPatients were registered and treated meglumine 20 mg/d routine clinical practice (observation period, 156 weeks). Data on...
Many pharmacoepidemiologic studies using large-scale databases have recently been utilized to evaluate the safety and effectiveness of drugs in Western countries. In Japan, however, conventional methodology has applied postmarketing surveillance (PMS) collect information on new meet regulatory requirements. Conventional PMS entails enormous costs resources despite being an uncontrolled observational study method. This is aimed at examining possibility database research as a more efficient...
A unique database named 'AN-SAPO' was developed by Iwato Corp. and Japan Brain in collaboration with the psychiatric clinics run Himorogi Group Japan. The AN-SAPO includes patients' depression/anxiety score data from a mobile app medical records prescription software 'ORCA'. On app, severity can be evaluated answering 20 brief questions scores are transferred to together on ORCA. Currently, this is used at Group's has over 2000 accumulated since November 2013. Since covers demographic data,...
To explore the potential factors impacting efficacy of venlafaxine extended release (ER) and treatment differences between 75 mg/day 75-225 dose in patients with major depressive disorder (MDD).We performed exploratory post hoc subgroup analyses a randomized, double-blind, placebo-controlled study conducted Japan. A total 538 outpatients aged 20 years or older primary diagnosis MDD who experienced single recurrent episodes were randomized into three groups: fixed-dose, flexible-dose,...
Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways catecholamines (CAs), which are important hormones in regulating blood pressure both central and peripheral sympathetic nerve endings. We have reported rapid determination method COMT activity using high-performance liquid chromatography (HPLC)-fluorescence detection. In present study, we applied to brain tissues, cerebral cortex, cerebellum, hypophysis hypothalamus. activities were assessed measuring...
Post-biopsy bleeding is the primary complication of renal biopsy. Retroperitoneal haematoma a rare but severe complication; it commonly occurs among patients who have risk factors or vascular lesions. The risks in with immunoglobulin A (IgA) nephropathy (IgAN) been discussed literature, clinical data are lacking. Here, we report case post-biopsy retroperitoneal accompanied by decreased coagulation factor XIII (FXIII) patient IgAN. 14-year-old male haematuria and proteinuria no family history...
The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical approach was employed NP exploration using the genus Paraconiothyrium sp. isolated root soil Ficus microcarpa on Noho Island, Okinawa. Consequently, we five compounds, including new chromone, (+)-nohocumone (1), as well four known (S)-(+)-known chromone (2), 10-norparvulenone (3), sclerotinin A (4), and calbistrin (5), culture broth FKR-0637. planar...
The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical approach was employed NP exploration using the genus Paraconiothyrium sp. isolated root soil Ficus microcarpa on Noho Island, Okinawa. Consequently, we five compounds, including new chromone, nohocumone (1), as well four known chromone (2), 10-norparvulenone (3), sclerotinin A (4), and calbistrin (5), culture broth FKR-0637. planar structure 1 were...
In February 2015, we introduced a drug verification and quantity management system using personal digital assistants medicine barcodes to prevent dispensing errors. We evaluated the effect of this by comparing number errors incident cases for one year before after introduction. The time required was prolonged from about 28.4 seconds 37.3 per drug, 1.3 times. introduction significantly decreased 33.8 ± 4.7 month 5.8 0.8 (P < 0.01). addition, incidents 6.0 0.9 3.2 0.5 = 0.02). seems be useful...
Abnormal hemoglobin, which was latter identified as hemoglobin Zürich, discovered in a 45-year-old female with severe valvular heart disease, congestive failure and moderate anemia hyperbilirubinemia. Same abnormal demonstrated her two apparently healthy sons. This is the first reported family of Zurich Japan.
Two captive mature female California sea lions (Zalophus californianus) were trained to provide saliva samples for the purpose of diagnosing pregnancy at an early stage and monitoring reproductive cycles. Saliva was collected from 1 4 times per week autumn 1996 spring 2000, progesterone concentration in measured by enzyme immunoassay (EIA) In spite differences between two used study, data thus obtained allowed us plot their annual cycles diagnose a few months earlier than possible using...