A5100455943- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer therapeutics and mechanisms
- Genomics and Chromatin Dynamics
- Nutritional Studies and Diet
- Neuroblastoma Research and Treatments
- Cardiovascular Health and Risk Factors
- Advanced Graph Neural Networks
- Lung Cancer Research Studies
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- RNA Research and Splicing
- Chromosomal and Genetic Variations
Rutgers, The State University of New Jersey
2011-2024
Jiangxi University of Traditional Chinese Medicine
2022
Didi Chuxing (China)
2019
Chinese Academy of Agricultural Sciences
2017
Institute of Animal Sciences
2017
Cardiovascular Institute of the South
2015
SynZyme Technologies (United States)
2011
Hydroxymethylcytosine, well described in DNA, occurs also RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet Drosophila. We map the transcriptome-wide hydroxymethylation landscape, revealing transcripts of many genes, notably coding sequences, identify consensus sites for hydroxymethylation. found RNA can favor mRNA translation. hydroxymethylated are to be most abundant Drosophila brain, Tet-deficient fruitflies suffer impaired...
Abstract Purpose: Genz-644282 [8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one] has emerged as a promising candidate for antitumor agents. This report describes the bone marrow colony-forming unit, granulocyte macrophage (CFU-GM) and tumor cell CFU activity of topoisomerase I (Top1) inhibitors, such Genz-644282, topotecan, irinotecan/SN-38, ARC-111, examines their in several human xenograft models. Experimental Design: Colony-forming assays...
The TET (Ten-eleven translocation) 1, 2 and 3 proteins have been shown to function as DNA hydroxymethylases in vertebrates their requirements documented extensively. Recently, the Tet also hydroxylate 5-methylcytosine RNA. 5-hydroxymethylcytosine (5hmrC) is enriched messenger RNA but of this modification has yet be elucidated. Because Cytosine methylation barely detectable Drosophila, it serves an ideal model study biological 5hmrC. Here, we characterized temporal spatial expression...
Modifications of mRNA, especially methylation adenosine, have recently drawn much attention. The rarer modification, 5-hydroxymethylation cytosine (5hmC), is not well understood and the subject this study. Vertebrate Tet proteins are 5-methylcytosine (5mC) hydroxylases catalyze transition 5mC to 5hmC in DNA. These enzymes been shown same function messenger RNAs both vertebrates Drosophila. gene essential Drosophila as knock-out animals do reach adulthood. We describe identification...
Predicting users' irregular trips in a short term period is one of the crucial tasks intelligent transportation system. With prediction, taxi requesting services, such as Didi Chuxing China, can manage resources to offer better services. There are several different scenes, commuting scene and entertainment scene. The origin destination more unsure than that scene, so both should be predicted. Moreover, on platform only part their real life, these data few weak samples. To address challenges,...
Abstract Modifications of mRNA, especially methylation adenosine, have recently drawn much attention. The rarer modification, 5-hydroxymethylation cytosine (5hmC), is not well understood and the subject this study. Vertebrate Tet proteins are 5-methylcytosine (5mC) hydroxylases catalyze transition 5mC to 5hmC in DNA. These enzymes been shown same function messenger RNAs both vertebrates Drosophila. gene essential Drosophila as knock-out animals do reach adulthood. We describe identification...
Introduction: J relationships of body mass index (BMI) with mortality have been described. However, little data are available on long-term follow-up in controlled clinical trials respect to cardiovascular (CV) and all cause mortality. Hypothesis: We tested whether there is a shape relationship between BMI CV at 22 years the Systolic Hypertension Elderly Program (SHEP). Methods: SHEP was placebo controlled, randomized trial antihypertensive therapy patients isolated systolic hypertension aged...
Abstract Modifications of mRNA, especially methylation adenosine, have recently drawn much attention. The rarer modification, 5-hydroxymethylation cytosine (5hmC), is not well understood and the subject this study. Vertebrate Tet proteins are 5-methylcytosine (5mC) hydroxylases enzymes catalyzing transition 5mC to 5hmC in DNA been shown same function messenger RNAs both vertebrates Drosophila. gene essential Drosophila because knock-out animals do reach adulthood. We describe identification...