A5071873092- Inflammasome and immune disorders
- Mesenchymal stem cell research
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Advanced Glycation End Products research
- Ferroptosis and cancer prognosis
- Adenosine and Purinergic Signaling
- Gout, Hyperuricemia, Uric Acid
- Diabetic Foot Ulcer Assessment and Management
- interferon and immune responses
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Biomedical Ethics and Regulation
Sun Yat-sen Memorial Hospital
2018-2023
Sun Yat-sen University
2018-2023
University of Tübingen
2022
Mesenchymal stromal cells (MSCs) have become the most commonly used adult stem in regenerative medicine. Preclinical studies shown that MSCs-based therapy is a potential new treatment approach for neurological diseases. Intrathecal injection has unique feature which allows to directly migrate lesion site patients with central nervous system (CNS) In this study, we evaluate safety and feasibility of intrathecal allogeneic bone marrow-derived MSCs (BM-MSCs) This open-label clinical study...
Abstract Background Pyroptosis is a new type of programmed cell death, which induces strong pro-inflammatory reaction. However, the mechanism pyroptosis after brain ischemia/reperfusion (I/R) and interaction between different neural cells are still unclear. This study comprehensively explored mechanisms interactions microglial neuronal in simulated I/R environment vitro. Methods The BV2 HT22 were treated by oxygen-glucose deprivation/reoxygenation (OGD/R). pyroptotic detected dye uptake...