A5074091695- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Genomics and Chromatin Dynamics
- Hippo pathway signaling and YAP/TAZ
- Viral-associated cancers and disorders
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- Liver physiology and pathology
- Genetics and Neurodevelopmental Disorders
- TGF-β signaling in diseases
- Cancer-related gene regulation
- Pancreatic function and diabetes
German Cancer Research Center
2025
Heidelberg University
2025
Centre de Recherche en Cancérologie de Toulouse
2020-2024
Université Toulouse III - Paul Sabatier
2020-2024
Université de Toulouse
2020-2024
Inserm
2020-2024
Centre National de la Recherche Scientifique
2023-2024
Abstract Several studies have linked the E3 ubiquitin ligase TRIP12 (Thyroid hormone Receptor Interacting Protein 12) to cell cycle. However, regulation and implication of this protein during cycle are largely unknown. In study, we show that expression is regulated cycle, which correlates with its nuclear localization. We identify an euchromatin-binding function mediated by a N-terminal intrinsically disordered region. demonstrate functional in mitotic entry controlling duration DNA...
Abstract The E3 ubiquitin ligase thyroid hormone receptor interacting protein 12 (TRIP12) has been implicated in pancreatic adenocarcinoma (PDAC) through its role mediating the degradation of pancreas transcription factor 1a (PTF1a). PTF1a is a essential for acinar differentiation state that notably diminished during early steps carcinogenesis. Despite these findings, direct involvement TRIP12 onset cancer yet to be established. In this study, we demonstrated was significantly upregulated...
Transforming growth factor β (TGFβ) pathway is a master regulator of cell proliferation, differentiation, and death. Deregulation TGFβ signalling well established in several human diseases including autoimmune disorders cancer. Thus, understanding molecular pathways governing may help better understand the underlying causes some those conditions. Here, we show that HECT domain E3 ubiquitin ligase TRIP12 controls multiple models. Interestingly, control completely independent its activity....
Abstract Background & Aims Although specialized and dedicated to the production of digestive enzymes, pancreatic acinar cells harbor a high plasticity are able modify their identity. They undergo reversible acinar-to-ductal cell metaplasia (ADM) through epigenetic silencing lineage gene program mainly controlled by PTF1a (Pancreas Transcription Factor 1a). ADM becomes irreversible in presence oncogenic Kras mutations leads formation preneoplastic lesions. We investigated role E3...
ABSTRACT Chromatin compaction is crucial for the faithful expression and integrity of genome. Although largely studied, proteins mechanisms that control chromatin are not entirely discovered. We previously showed nuclear HECT-type E3 ubiquitin ligase Thyroid hormone Receptor Interacting Protein 12 (TRIP12) tightly associated to chromatin. As TRIP12 overexpressed in several types cancers, we explored herein consequences a overexpression on homeostasis. First, established proxisome unveiled...