A5054436342- CAR-T cell therapy research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Acute Lymphoblastic Leukemia research
- Supramolecular Self-Assembly in Materials
Xiamen University
2018-2021
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive and memory impairment. It the most common neurological that causes dementia. Soluble amyloid-beta oligomers (AβO) in blood or cerebrospinal fluid (CSF) are pathogenic biomarker correlated with AD.A simple electrochemical biosensor using graphene oxide/gold nanoparticles (GNPs) hydrogel electrode was developed this study. Thiolated cellular prion protein (PrPC) peptide probe immobilized on GNPs of...
Adoptive transfer of immune cells is being actively pursued for cancer treatment. Natural killer (NK) cells, a class cytotoxic generally lack inherent selectivities toward cancer. To bestow tumor-targeting abilities and enhance anticancer efficacy, new strategy established to glycoengineer NK cells. Carbohydrate-based ligands CD22, marker B cell lymphoma, are introduced onto through either metabolic engineering or glyco-polymer insertion. Such exhibited greatly enhanced cytotoxicities CD22+...
While Cetuximab can be used to treat KRAS wild-type colon cancer cells by targeting EGFR and inhibiting the activation of downstream signaling pathways, it exhibits little therapeutic effect on mutant cells. Natural killer (NK) are a class powerful immune with anticancer activities. However, NK typically lack inherent tumor abilities. Here, new method is established bestow NK-92 abilities installing cetuximab cell surface. Through metabolic glycoengineering, azide groups were introduced onto...