A5074702342- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Exercise and Physiological Responses
- Long-Term Effects of COVID-19
- Microbial Metabolism and Applications
- Muscle metabolism and nutrition
- Diphtheria, Corynebacterium, and Tetanus
- Human Health and Disease
- Historical and Archaeological Studies
- Infectious Diseases and Tuberculosis
- Geology and Paleoclimatology Research
- COVID-19 Impact on Reproduction
- Pediatric health and respiratory diseases
- Probiotics and Fermented Foods
- Metabolomics and Mass Spectrometry Studies
- Biochemical and Structural Characterization
- Archaeology and ancient environmental studies
- Bacteriophages and microbial interactions
- Educational Methods and Teacher Development
- Immune responses and vaccinations
Scientific Center of Family Health Problems and Human Reproduction
2017-2024
Perm State University
2024
Institute of Physiologically Active Compounds
2018-2023
Abstract The Ural Mountains represent a distinctive bioecological and climatic boundary between Europe Asia, simultaneously uniting them through cultural, ethnic, economic ties throughout history. To investigate these complex human-environment interactions during the last ~ 10,000, we obtained peat core Shabunichi-1 analyzed it using AMS radiocarbon dating, loss-on-ignition, pollen, non-pollen palynomorphs, micro- macrocharcoal analyses. Our palaeoecological study demonstrate that climate...
Eastern Siberia (Russia) and Mongolia are borderline regions in Asia with a high incidence of tuberculosis (TB). In this study, we investigated the transborder transmission Mycobacterium focus on endemic epidemic clones drug resistance. M. isolates (287 from 754 Russia) were collected using cross-sectional population-based surveys between 2010 2016. The genotyped 24 variable number tandem repeat loci by testing key markers to discriminate within Beijing genotype. All divided into 427...
The formation and development of the Kungur forest-steppe has been a controversial topic for almost 150 years due to its location within belt hemiboreal forests in pre-Urals European Russia. To further knowledge on manmade versus natural origin we conducted palaeoecological study reconstructing regional vegetation history Mid-Kama region as well local bog additional archaeobotanical studies nearby. Detailed loss-on-ignition analysis, peat properties high resolution radiocarbon dating were...
Background . The study of the lower respiratory tract microbiome has been actively developed inrecent years with help whole genome sequencing (WGS) methods. Due to this, it became clear that nature lungs microbiota is very different from other microbial communities inhabiting human body. One important directions in pathological biocenosis role satellite tuberculosis focus. aim work To isolate and characterize oxygen-tolerant anaerobes necrotic contents tuberculomas. Materials methods Biopsy...
The SARS-CoV-2 pandemic is a big challenge for humanity. COVID-19 severity differs significantly from patient to patient, and it important study the factors protecting severe forms of disease. Respiratory microbiota may influence patient's susceptibility infection disease due its ability modulate immune system response host organism. This data article describes microbiome dataset upper respiratory tract positive patients Russia. reports microbial community profile 335 human nasopharyngeal...
A comparative molecular epidemiological analysis of the population structure Mycobacterium tuberculosis in Mongolia and neighboring regions Russia was conducted. The aim determining mutual influence TB studied countries. Selected samples Mongolian (309 strains) Russian (933 cohorts were carried out based on results genotyping (used deletion for RD 105/207, MIRU-VNTR 24 subtyping clone CC2/W148 by specific kdpD gene). study indicate isolation transmission infection Mongolia, despite activity...
Aim. To estimate the dynamics changes in population structure of tuberculosis (ТВ) pathogen Irkutsk region by comparison genotypes M. from patients different age groups. Materials and methods. 588 epidemiologically unrelated strains isolates 567 ТВ were characterized using 24-locus MIRU-VNTR typing. 160 belonged to 59 isolated «young» people with who bom after 1990 101 born before 1955. Results. Two-thirds samples (427/567) genotype Beijing dominance two subtypes belonging modem epidemic...
Mongolia and Russia are among the countries with high tuberculosis (TB) burden. The prevalence of tuberculosis, including multidrug-resistant (MDR), in Eastern Siberia bordering is significantly higher than European part Russia. In addition, unlike Mongolia, characterized by a HIV infection. cross-border spread socially significant infections these seems to occur due their wide-range cooperation cultural exchange. Whereas infection has no epidemiological significance for at moment, however,...
Levofloxacin is a preferred drug for multidrug-resistant (MDR)-tuberculosis (TB) with bactericidal activity that correlates the pharmacokinetic exposures of serum peak concentration (Cmax) and total area under time curve (AUC0-24). Pharmacokinetic can be measured to personalize dosing reach targets, but this practice requires venepuncture, chromatographic or mass spectrometry equipment, technical expertise. We sought demonstrate accuracy using urine colorimetry as more feasible estimation...
Background. The viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent new infection, is becoming increasingly important in clinical and epidemiological contexts. Despite this, there are significant complexities implementation quantitative measurement into practice due to limited approaches its assessment. aim this work was develop an approach for SARS-CoV-2 analysis by value sample threshold cycles (Ct) relative Ct internal control obtained routine...
Background . Bedaquiline is a new and promising anti-tuberculosis drug, but longterm use requires resistance. This due to mutations in the atpE mmpR genes M. tuberculosis (MBT). The aim of research was test system for automated interpretation results predicting resistance bedaquiline by molecular data. Materials methods DNA isolated from strains Irkutsk region Yakutia. total quantity samples 27 Yakutia 21 region. study MBT genomes carried out on previously obtained authors territories (n =...
Normal lung microbiota is a small number of transient microbes; however, respiratory pathology may be associated with persistent microbial colonization the lungs. It remains poorly understood and mysterious part pathogenesis tuberculosis infection. The review considers general pathogenetic mechanisms effect in presents main methodological difficulties study microbiome. This aimed at analyzing results available studies on diverse composition human lungs using metagenomic sequencing methods....
The aim. research was conducted to assess the total antioxidant and glutathione status, superoxide dismutase activity in menopausal women with moderate asymptomatic COVID-19. Materials methods . Ninety two 45 69 years old were divided into groups: without COVID-19, not vaccinated, no antibodies SARS-CoV-2 (IgG) – control; COVID-19 main group; anti-SARS-CoV-2 IgG blood but who deny any symptoms of last 12 months Results. A lower peroxidase (GPx), (SOD) activities a higher reductase (GR)...
Статья посвящена основным вехам истории русских сёл и деревень, расположенных в пределах предполагаемого достопримечательного места «Наскальное искусство р. Томь». Деревни сёла по берегам Томи были основаны выходцами с Русского Севера, среди которых не только сторонники официального православия, но раскольники. Кроме того, свой вклад внесли представители коренных народов. Взаимодействие всех этих людей, всегда проходившее мирно, итоге привело к формированию населённых пунктов, существующих...
Background. Smell disorder is a recognized clinical symptom of COVID-19 infection. The problem the loss sense smell in structure pathogenesis during pregnancy remains unresolved. aim study. To determine and taste pregnant women with COVID-19, as well to evaluate relationship between number SARS-CoV-2 genome equivalents nasopharyngeal secretion. Material methods. In case-control study, 121 participated: 40 them were infected COVID-19; 81 not earlier at time survey was conducted July 2021....