A5021212875- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Urinary Bladder and Prostate Research
- Surgical Simulation and Training
- Urinary Tract Infections Management
- Minimally Invasive Surgical Techniques
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy-related medical research
- Diverticular Disease and Complications
- Hernia repair and management
- Uterine Myomas and Treatments
- Preterm Birth and Chorioamnionitis
- Anatomy and Medical Technology
- Endometriosis Research and Treatment
- Receptor Mechanisms and Signaling
- Urological Disorders and Treatments
- Colorectal Cancer Surgical Treatments
- Maternal and Perinatal Health Interventions
- Artificial Intelligence in Healthcare and Education
- Cell Image Analysis Techniques
- Bladder and Urothelial Cancer Treatments
- Menopause: Health Impacts and Treatments
- Delphi Technique in Research
- Mass Spectrometry Techniques and Applications
CMR Surgical (United Kingdom)
2019-2024
University of Birmingham
1980-2023
Birmingham Women’s and Children’s NHS Foundation Trust
2023
University of Nottingham
2023
University of Leeds
2023
King's College - North Carolina
2023
King's College London
2023
Harvard University Press
2023
University of Bristol
2023
Imperial College London
2023
Objective To assess the possible benefit of hormone replacement therapy (HRT) in secondary prevention ischaemic heart disease. Design A prospective randomised trial transdermal HRT women with definite Setting regional cardiac unit. Population Postmenopausal angiographically Methods total 255 postmenopausal proven disease were recruited and randomised; 134 treated 121 acted as controls. The seen at six monthly intervals. primary end points, which determined by a blinded assessor, admission to...
Objective To assess the efficacy and safety of duloxetine in women with stress urinary incontinence. Design Randomised double‐blind, placebo‐controlled clinical trial. Setting Fort‐six centres seven European countries Canada. Population Four hundred ninety‐four aged 24–83 years identified as having predominant symptoms incontinence using a algorithm that was 100% predictive urodynamic subgroup 34 women. Methods The case definition included symptom weekly episode frequency ≥7, absence urge...
Cervical cerclage using braided suture material disrupts vaginal microbial stability and increases inflammation.
BackgroundMinimal access surgery (MAS) is well-established in urological surgery. However, MAS technically demanding and associated with a prolonged learning curve. Robot-assisted laparoscopy has made progress overcoming these challenges.ObjectiveThe aim of this study was to evaluate the feasibility new robot-assisted surgical system (the Versius Surgical System; CMR Surgical, Cambridge, UK) for renal prostate procedures preclinical setting, at IDEAL-D phase 0.Design, participantsCadaveric...
Abstract The use of digital technology is increasing rapidly across surgical specialities, yet there no consensus for the term ‘digital surgery’. This critical as health technologies present technical, governance, and legal challenges which are unique to surgeon patient. We aim define surgery ethical issues surrounding its clinical application, identify barriers research goals future practice. 38 international experts, fields surgery, AI, industry, law, ethics policy, participated in a...
To present the first report of data from Versius Surgical Registry, a prospective, multicenter registry with ongoing collection across numerous surgical indications, developed to accompany Robotic System into clinical practice.A can be utilized minimize risk patients by establishing safety and effectiveness innovative medical devices generating thorough evidence base real-world data.Surgical outcome were collected inputted through secure online platform. Preoperative included patient age,...
To examine the effects of antimuscarinic agent solifenacin on urinary urgency, using a range novel and established outcome measures, as urgency is principal symptom overactive bladder syndrome (OAB).The study (SUNRISE, in treatment symptoms OAB rising dose, randomized, placebo-controlled, double-blind, efficacy trial) was 16-week, multicentre 5/10 mg 863 patients with for > or = 3 months. The primary variable change from baseline to endpoint number episodes severe without incontinence per 24...
Objectives Versius is a teleoperated surgical robotic system intended for use in minimal access surgery. This study aimed to validate the safety and effectiveness of user interface hands trained users identify address causes any errors. Design Surgical teams completed commercially representative training program over 3.5 days. After was completed, usability-related aspects were assessed. Setting A simulated operating room using cadaveric model. Participants consisting lead surgeon, assistant...
Abstract Objective To evaluate the utility of a new robot-assisted surgical system (the Versius Surgical System, CMR Surgical, Cambridge, UK) for use in minimal access general and colorectal surgery, preclinical setting. Summary background data Robot-assisted laparoscopy has been developed to overcome some important limitations conventional laparoscopy. The is designed assist surgeons performing surgery challenges associated with currently available robots. Methods Cadaveric sessions were...
ABSTRACT Objective To assess the results of sacrospinous colpopexy procedure for treatment vault prolapse following hysterectomy and marked uterovaginal prolapse. Design A prospective study all patients undergoing between December 1991 1992. Setting Kent Canterbury Hospital, Canterbury. Subjects Forty women with 24 Interventions All underwent posterior vaginal repair, enterocele sac obliteration colpopexy. In 48 an anterior repair suburethral buttressing sutures was also performed....
Abstract Objective The aim of this study was to provide an interim safety analysis the first 30 surgical procedures performed using Versius Surgical System. Background Robot-assisted laparoscopy has been developed overcome some important limitations conventional laparoscopy. new system is currently undergoing a first-in-human prospective clinical trial confirm and effectiveness device when performing minimal access surgery (MAS). Methods Procedures were by lead surgeon supported operating...
Background Robot-assisted minimal access surgery (MAS) reduces blood loss, recovery time, intraoperative and postoperative complications pain. However, uptake of robotic MAS remains low, suggesting there are barriers to its use. To overcome these barriers, a new surgical robot system, Versius, was developed based on the needs feedback surgeons teams. Methods The prototype designed observations in operating room (OR) previous interviews with surgeons. Formative studies teams were used refine...
BackgroundMiscarriage in the second trimester and preterm birth are significant global problems. Vaginal cervical cerclage is performed to prevent pregnancy loss birth. We aimed determine effectiveness of a monofilament suture thread compared with braided on rates women undergoing cerclage.MethodsC-STICH was pragmatic, randomised, controlled, superiority trial done at 75 obstetric units UK. Women singleton who received vaginal due history or premature birth, if indicated by ultrasound, were...
Objective: The aim of this study was to demonstrate the ability Versius Surgical System successfully and safely complete cholecystectomy. Background: system has been developed in-line with surgeon feedback overcome limitations conventional laparoscopy enhance experience patient outcomes. Here we present results from cholecystectomy cohort a completed early clinical trial, which designed broadly align Stage 2b Idea, Development, Exploration, Assessment, Long-term follow-up framework for...
The class A G-protein-coupled receptors (GPCRs) Orexin-1 (OX1) and Orexin-2 (OX2) are located predominantly in the brain linked to a range of different physiological functions, including control feeding, energy metabolism, modulation neuro-endocrine function, regulation sleep-wake cycle. natural agonists for OX1 OX2 two neuropeptides, Orexin-A Orexin-B, which have activity at both receptors. Site-directed mutagenesis (SDM) has been reported on peptides provided important insight into key...