Ling Chen

ORCID: 0000-0003-2181-8410
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About
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Research Areas
  • Oral Health Pathology and Treatment
  • Oral microbiology and periodontitis research
  • Genetic Associations and Epidemiology
  • Pharmacological Effects of Natural Compounds
  • Neurological Disorders and Treatments
  • Streptococcal Infections and Treatments
  • Neurological Disease Mechanisms and Treatments
  • Diabetes Treatment and Management
  • Renin-Angiotensin System Studies
  • Sodium Intake and Health
  • Advanced Measurement and Detection Methods
  • Medicinal Plants and Bioactive Compounds
  • Microscopic Colitis
  • Inflammatory Biomarkers in Disease Prognosis
  • Liver Disease Diagnosis and Treatment
  • Angiogenesis and VEGF in Cancer
  • Dental Implant Techniques and Outcomes
  • Vascular anomalies and interventions
  • Healthcare Systems and Public Health
  • Plant-based Medicinal Research
  • Thyroid Disorders and Treatments
  • Ion Transport and Channel Regulation
  • Salivary Gland Disorders and Functions
  • Pharmacy and Medical Practices
  • Stroke Rehabilitation and Recovery

First Affiliated Hospital of Fujian Medical University
2008-2024

Fujian Medical University
2008-2024

Union Hospital
2022

Massachusetts General Hospital
2020-2022

Broad Institute
2020-2022

Guangzhou University of Chinese Medicine
2021

Harvard University
2020

St Thomas' Hospital
2018

Ministry of Public Security of the People's Republic of China
2011

Chinese People's Liberation Army
2009

Background : This study aims to assess visfatin concentrations in serum and gingival crevicular fluid (GCF) investigate this relationship patients with type 2 diabetes mellitus (T2DM) chronic periodontitis (CP) before after non‐surgical periodontal treatment. Methods: Fifty‐four T2DM CP were recruited. The randomly divided into two groups: treatment control. Serum GCF glycated hemoglobin (HbA1c) levels measured by enzyme‐linked immunosorbent assay at different time points (at baseline 3 6...

10.1902/jop.2015.140476 article EN Journal of Periodontology 2015-03-19

Abstract Glucocorticoids have multiple therapeutic benefits and are used both for immunosuppression treatment purposes. Notwithstanding their benefits, glucocorticoid use often leads to hyperglycemia. Owing the pathophysiologic overlap in glucocorticoid-induced hyperglycemia (GIH) type 2 diabetes (T2D), we hypothesized that genetic variation pathways contributes T2D risk. To determine contribution of action on risk, conducted studies. First, performed gene-set enrichment analyses 3 collated...

10.1210/jendso/bvaa121 article EN cc-by-nc-nd Journal of the Endocrine Society 2020-08-24

Abstract Background Studies have shown that visfatin is an inflammatory factor closely related to periodontitis. We examined the levels of in gingival crevicular fluid (GCF) and tissues under different periodontal conditions, order provide more theoretical basis for exploring role pathogenesis Methods enrolled 87 subjects, with 43 chronic periodontitis (CP) group, 21 gingivitis (CG) 23 health (PH) group. Periodontal indexes (PD, AL, PLI, BI) were recorded. GCF samples collected...

10.1186/s12903-024-04299-2 article EN cc-by BMC Oral Health 2024-05-02

The aim of this study was to establish a nomogram quantify the risk postoperative pulmonary venous obstruction (PVO) and make scientific decision through curve.In total, 151 PVO patients with total anomalous connection (TAPVC) repair in our hospital from December 2008 2015 were involved study. A generated based on contribution weights variables, which found out by logistic analysis. optimal clinical point determined analysis impact curve, could assess net benefit between each independent...

10.3389/fcvm.2022.733253 article EN cc-by Frontiers in Cardiovascular Medicine 2022-02-16

Abstract Background: Vascular cognitive impairment and dementia (VCID) is the second most common form of after Alzheimer’s disease (AD). Currently, mechanistic insights into evolution progression VCID are not fully understood. White matter change represents an invariant feature both AD. Compelling clinical neuroimaging pathological evidence suggest a link between white changes neurodegeneration. Our prior study detected non-perfusion lesions in mice with partial deficiency endothelial nitric...

10.21203/rs.3.rs-563166/v1 preprint EN cc-by Research Square (Research Square) 2021-06-07

Abstract Introduction: Poststroke depression (PSD) is the most common mental complication after stroke and has a serious impact on functional outcomes quality of life. Antidepressants are first-line treatment for PSD, but many reported side effects remain. Clinical research shown that acupuncture positive effect PSD. This trial aims to study efficacy safety PSD explore its cognitive function. It hypothesized improves depressive symptom, behavior negative emotion processing bias in Methods:...

10.21203/rs.3.rs-76109/v1 preprint EN cc-by Research Square (Research Square) 2021-06-28
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