A5045439955- Management of metastatic bone disease
- Palliative Care and End-of-Life Issues
- Advanced Radiotherapy Techniques
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Microtubule and mitosis dynamics
- Photoacoustic and Ultrasonic Imaging
- DNA Repair Mechanisms
- Glioma Diagnosis and Treatment
- Optical Coherence Tomography Applications
- Lung Cancer Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Optical Imaging and Spectroscopy Techniques
- Radiation Dose and Imaging
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- Bone and Joint Diseases
- Spinal Fractures and Fixation Techniques
- Ultrasound Imaging and Elastography
- Cancer-related cognitive impairment studies
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
China Electronics Technology Group Corporation
2024
Long Beach Medical Center
2023
RTOG Foundation
2020
University of California, Irvine
2008-2019
Orange Coast Memorial Medical Center
2019
Long Beach Memorial Medical Center
2019
Memorial Medical Center
2017
University of California, Irvine Medical Center
2015-2016
UC Irvine Health
2016
VA Long Beach Healthcare System
2015
The spindle assemble checkpoint (SAC) is critical for accurate chromosome segregation. Hec1 contributes to segregation in part by mediating SAC signaling and alignment. However, the molecular mechanism which modulates alignment remains poorly understood. We found that serine 165 (S165) preferentially phosphorylated at kinetochores. Phosphorylated (pS165) specifically localized kinetochores of misaligned chromosomes, showing a spatiotemporal distribution characteristic molecules. Expressing...
Spindle integrity is critical for efficient mitotic progression and accurate chromosome segregation. Deregulation of spindles often leads to structural functional aberrations, ultimately promoting segregation errors aneuploidy, a hallmark most human cancers. Here we report the characterization previously identified sarcoma antigen (gene located at 19p13.11), Hice1, an evolutionarily nonconserved 46-kDa coiled-coil protein. Hice1 shows distinct cytoplasmic localization associates with...
NEK1, the first mammalian ortholog of fungal protein kinase never-in-mitosis A (NIMA), is involved early in DNA damage sensing/repair pathway. defect repair NEK1-deficient cells suggested by persistence double strand breaks after low dose ionizing radiation (IR). also fail to activate checkpoint kinases CHK1 and CHK2, arrest properly at G1/S or G2/M-phase checkpoints damage. We show here that suffer major errors mitotic chromosome segregation cytokinesis, become aneuploid. These transform,...
Objectives: To use multiphoton microscopy to image collagen fibers and matrix structure in nonfixed human keloid tissue normal facial skin obtained following surgery compare the findings existing knowledge of morphology determine if this technology is a suitable adjunct for conventional histology. Methods: Epidermis was removed expose fibroblast-rich dermal layer that then imaged using confocal microscope (Zeiss-Meta 510; Carl Zeiss, Jena, Germany). An 800-nm tunable titanium/sapphire...
// Yumay Chen 1 , Chi-Fen 2 Rosaria Polci 3 Randy Wei Daniel J. Riley 3,4 and Phang-Lang Department of Medicine, Division Endocrinology, University California at Irvine Biological Chemistry, Nephrology, The Texas Health Science Center San Antonio 4 Surgery, Correspondence: Chen, email: Keywords : Renal Cell Carcinoma, VDAC1, Nek1 Received March 18, 2014 Accepted May 24, Published 25, Abstract cell carcinoma (RCC) is a heterogeneous disease with resistance to systemic chemotherapy. Elevated...
Activation of the CYC1 upstream activation site, UAS2, and transcription several other genes encoding respiratory functions requires product regulatory gene HAP2. We report here isolation characterization a second UAS2 gene, HAP3. Like mutations in HAP2, mutation HAP3 abolishes activity prevents growth on nonfermentable carbon sources. The was cloned and, surprisingly, found to encode two divergently transcribed, overlapping transcripts: 570-base RNA 3-kilobase (kb) RNA. Chromosomal...
Previous studies have stipulated Hec1 as a conserved kinetochore component critical for mitotic control in part by directly binding to fibers of the spindle and recruiting assembly checkpoint proteins Mad1 Mad2. has also been reported localize centrosomes, but its function there yet be elucidated. Here, we show that specifically colocalizes with Hice1, previously characterized centrosomal microtubule-binding protein, at pole region during mitosis. In addition, C-terminal binds coiled-coil...
This Viewpoint outlines why universal training in palliative care for clinicians who provide oncologic services is likely to reduce costs the health system and improve patients' health-related quality of life.
Radiation therapy (RT) can effectively palliate a variety of symptoms in patients with metastatic cancer, using relatively low doses that infrequently cause major side effects. However, palliative radiation is often underutilized and sub-optimally implemented. In this study, we surveyed the Society Palliative Oncology (SPRO) membership to identify barriers appropriate referral for RT they encounter their practice, specific groups physicians who oncologists believed would benefit most from...
Radiation therapy is well known to provide palliation for a variety of localized cancer symptoms, which can improve patient quality life and reduce caregiver burden stressors. Palliative radiation plays critical roles in the management pain from bone metastases, neurological symptoms brain metastases or spinal cord compression, local caused by mass effect, invasion.
105 Background: Radiation oncologists are frequently involved in providing palliative and supportive care (PSC) for patients with advanced cancers through delivery of radiation. Whether they confident their ability to assess initiate treatments pain, non-pain, psychosocial distress is unknown. The American Society Oncology (ASTRO) surveyed its practicing members the United States on self-assessment primary PSC skills, access continuing medical education PSC. Methods: We electronically 4,093...
As palliative care (PC) moves upstream in the course of advanced illness, it is critical that PC providers have a broad understanding curative and treatments for serious diseases. Possessing working knowledge radiation therapy (RT), one three pillars cancer care, crucial to given RT's role both settings. This article provides with primer on vocabulary RT; team people involved planning common indications, benefits, side effects treatment.
Our case acts to highlight the numerous presentations of polyglandular autoimmune syndromes. A 62-year-old Taiwanese woman with a history schizophrenia presented our emergency department brain tumour causing her headaches. She was admitted due severe anaemia, and after further investigation, patient discovered have pernicious anaemia thyroiditis-consistent diagnosis syndrome IIIb. Her underlying primary psychiatric then questioned. The endocrinopathies were likely delayed for many years...