A5085588210- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- Anatomy and Medical Technology
- Acute Myeloid Leukemia Research
- Biomedical Ethics and Regulation
- Folate and B Vitamins Research
- Porphyrin Metabolism and Disorders
- Innovative Microfluidic and Catalytic Techniques Innovation
- Multiple Myeloma Research and Treatments
- Pluripotent Stem Cells Research
- Chronic Myeloid Leukemia Treatments
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Iron Metabolism and Disorders
- Advanced Cellulose Research Studies
- Cancer-related gene regulation
- Reconstructive Facial Surgery Techniques
- CRISPR and Genetic Engineering
- Bone Tissue Engineering Materials
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hepatitis C virus research
- Parvovirus B19 Infection Studies
- Cell Image Analysis Techniques
Swansea University
2016-2020
Morriston Hospital
2019
Versus Arthritis
2012-2015
Cardiff University
2012-2015
University Hospital Llandough
2002-2005
Icahn School of Medicine at Mount Sinai
1995-1999
University of Wales
1995-1999
University of Pavia
1999
Western Infirmary
1999
University Hospital of Wales
1996
Background: One of the main challenges for extrusion 3D bioprinting is identification non-synthetic bioinks with suitable rheological properties and biocompatibility. Our aim was to optimize compare printability crystal, fibril blend formulations novel pulp derived nanocellulose assess biocompatibility human nasoseptal chondrocytes. Methods: The crystalline, fibrillated determined by assessing resolution (grid-line assay), post-printing shape fidelity rheology (elasticity, viscosity shear...
X-linked sideroblastic anemia (XLSA) is caused by muta- tions of the erythroid-specific 6-aminolevulinate synthase gene (ALAS2) resulting in deficient heme synthesis.The characteristic hypochromic, microcytic typically be- comes manifest first three decades life.Hematologic response to pyridoxine variable and rarely complete.We report two unrelated cases highly pyridoxine-responsive XLSA geriatric patients previously diagnosed with refractory ringed sideroblasts.A unaf- fected 77-yr-old male...
This study investigated whether treatment of articular cartilage chondrocytes with a combination oncostatin M (OSM) and interleukin-1 (IL-1) could induce degradative phenotype that was mediated through the protein kinase R (PKR) signalling pathway.High-density monolayer cultures full depth, bovine were treated OSM IL-1 (OSM+IL-1) for 7 days.To inhibit activation PKR, pharmacological inhibitor PKR added to duplicate cultures.Pro-and active matrix metalloproteinase-9 (MMP9) MMP9 mRNA signifi...
Since cartilage-derived stem/progenitor cells (CSPCs) were first identified in articular cartilage using differential adhesion to fibronectin, their self-renewal capacity and niche-specific lineage preference for chondrogenesis have propelled application tissue engineering. In many adult tissues, are recognised be involved homeostasis. However, the role of nasoseptal CSPCs has not yet been elucidated. Our aim was isolate characterise alongside chondrocyte populations determine chondrogenic...
Nasoseptal cartilage has been assumed to be isotropic, unlike the well-defined zonal organization of articular attributed postnatal biomechanical loading. We know from clinical experience that malrotation surgical nasoseptal grafts can lead increased graft absorption. Other studies have also suggested directionally dependent compressive stiffness suggesting anisotropy, but morphological investigations are lacking. This study characterizes immature and mature native bovine using a combination...
3D bioprinting has the potential to replicate complex tissue architecture and biomanufacture physiologically relevant multicellular constructs on demand. In article number 1700264, Stuart Kyle, Iain S. Whitaker, co-workers review a new generation of bioinks with suitable biocompatibility high shape/print fidelity, that have match or exceed physical, chemical biological properties human tissue, when combined appropriate cell source. Image Bioprinter kindly provided by Aether.
During this research, a 3D bioprinted ear structure has been produced from hybrid gelatin and alginate bioink hydrogel. Using dual in situ crosslinking, high-resolution the shape of formed which is capable maintaining live cells for 3 weeks culture. Staining shown presence formation extracellular matrix proteins postbioprinted tissue constructs. This research shows that chondrogenesis successful have occurred. process potential to enhance field reconstructive surgery medicine, by enabling...