A5050364478- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Angiogenesis and VEGF in Cancer
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cell Adhesion Molecules Research
- Atrial Fibrillation Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Advanced Proteomics Techniques and Applications
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Platelet Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Non-Invasive Vital Sign Monitoring
- Contact Dermatitis and Allergies
- Adipose Tissue and Metabolism
- Infective Endocarditis Diagnosis and Management
- Anesthesia and Pain Management
- Fuel Cells and Related Materials
University of Minnesota
2016-2024
Minneapolis Institute of Arts
2021
Saint Anthony College of Nursing
2021
University of Washington
2016-2018
Medical College of Wisconsin
2006-2017
University of Minnesota Medical Center
2017
University of Pennsylvania
2009
Background: As heart failure prevalence continues to increase in the setting of a static donor supply, left ventricular assist device (LVAD) therapy for end-stage grow. Anecdotal evidence suggests that malalignment LVAD inflow cannula may thrombosis risk, but this effect has not been explored mechanistically or quantified statistically. Our objective is elucidate impact surgical angulation on thrombogenicity. Methods and Results: Unsteady computational fluid dynamics used conjunction with...
This study quantifies thrombogenic potential (TP) of a wide range left ventricular assist device (LVAD) outflow graft anastomosis angles through state-of-the-art techniques: 3D imaged-based patient-specific models created via virtual surgery and unsteady computational fluid dynamics with Lagrangian particle tracking. aims at clarifying the influence single parameter (outflow angle) on thrombogenesis associated flow patterns in aortic root after LVAD implantation. is an important...
Abstract Background There is considerable debate about the hemodynamic effects of veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO). Aims To evaluate changes in left ventricular (LV) function, volumes, and work patients treated with VA‐ECMO using invasive LV catheterization three‐dimensional echocardiographic volumes. Methods Patients on underwent evaluation due to concerns regarding candidacy for decannulation. Hemodynamic parameters were reported as means±standard deviations or...
The current study evaluates quantitatively the impact that intermittent aortic valve (AV) opening has on thrombogenicity in arch region for patients under left ventricular assist device (LVAD) therapy. influence of flow through AV, once every five cardiac cycles, patterns ascending is measured a patient-derived computed tomography image-based model, after LVAD implantation. mechanical environment flowing platelets investigated, by statistical treatment outliers Lagrangian particle tracking,...
The prevalence of ventricular assist device (VAD) therapy has continued to increase due a stagnant donor supply and growing advanced heart failure (HF) population. We hypothesize that left (LV) size strongly influences biocompatibility risk thrombosis. Unsteady computational fluid dynamics (CFD) was used in conjunction with patient-derived modeling virtual surgery standard, apically implanted inflow cannula. A dual-focus approach evaluating thrombogenicity employed: platelet-based metrics...
Background Intermittent fasting (IF) confers pleiotropic cardiovascular benefits including restructuring of the gut microbiome and augmentation cellular metabolism. Pulmonary arterial hypertension (PAH) is a rare lethal disease characterized by right ventricular (RV) mitochondrial dysfunction resultant lipotoxicity dysbiosis. However, effects IF on RV function in PAH are unexplored. Therefore, we investigated how altered microbiota composition, function, survival monocrotaline model PAH....
Abstract Shortly after the discovery of endothelial progenitor cells (EPCs) in 1997, many clinical trials were conducted using EPCs as a cellular based therapy with goal restoring damaged organ function by inducing growth new blood vessels (angiogenesis). Results disappointing, largely because and molecular mechanisms EPC-induced angiogenesis not clearly understood. Following injection, must migrate to target tissue engraft prior induction angiogenesis. In this study EPC migration was...
Treatment of end-stage heart failure includes cardiac transplantation or ventricular assist device (VAD) therapy. Although increasingly prevalent, current VAD therapy has inherent complications, including thrombosis. Studies have demonstrated that implantation alters intracardiac blood flow, creating areas stagnation predispose to thrombus formation. Two potential surgical configurations exist for implantation: through the apical diaphragmatic surfaces heart. We hypothesized causes more than...
Venous-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment for acute cardiogenic shock in patients who also have lung injury predisposes development of a serious complication called "north-south syndrome" (NSS) which causes cerebral hypoxia. NSS is poorly characterized and hemodynamic studies focused on perfusion ignoring the heart. We hypothesized heart would be more likely to receive hypoxemic blood than brain due proximity coronary arteries aortic annulus. To test this, we...
Bone marrow-derived endothelial progenitor cells (BM-EPCs) are stimulated by vascular growth factor-A (VEGF-A) and other potent proangiogenic factors. During angiogenesis, an increase in VEGF-A expression stimulates BM-EPCs to enhance tube formation contribute microvessel density. Hypoxia is known produce enhanced angiogenic response heightened levels of have been seen oxygen deprived epithelial cells, yet the pathways for signaling not described. This study explores influence hypoxia on rat...
Endothelial progenitor cells (EPCs) are a rare population of that participate in angiogenesis. To effectively use EPCs for regenerative therapy, the mechanisms by which they tissue repair must be elucidated. This study focused on process activated bind to target tissue. It has been demonstrated can endothelial (ECs) through tumore necrosis factor-α (TNF-α)-regulated vascular cell adhesion molecule 1/very-late antigen 4 (VLA4) interaction. VLA4 high or low affinity state, is difficult...
Endothelial progenitor cells (EPCs) promote angiogenesis, and clinical trials suggest autologous EPC-based therapy may be effective in treatment of vascular diseases. Albeit promising, variability the efficacy EPCs associated with underlying disease states has hindered realization therapy. Here we first identify characterize EPC dysfunction a rodent model (SS/Mcwi rat) that exhibits impaired angiogenesis. To molecular candidates mediate angiogenic potential these cells, performed broad...
Objective Diabetes Mellitus (DM) has reached epidemic levels globally. A contributing factor to the development of DM is high blood glucose (hyperglycemia). One complication associated with a decreased angiogenesis. The Matrigel tube formation assay (TFA) most widely utilized in vitro designed assess angiogeneic factors and conditions. In spite widespread use TFAs, quantification labor-intensive subjective, often limiting experiential design interpretation results. This study describes...
Background:The aim of this study was to compare rehabilitation protocol and operative treatment in a population patients with diagnosis small medium rotator cuff tears (≤3 cm), the null hypothesis being that there would been no difference terms clinical outcomes patient's satisfaction between surgical treatment.Methods: Patients supraspinatus were retrospectively enrolled divided 2 groups: arthroscopic repair (group A, 20 patients) reinstated B, 18 patients).At mean follow-up months, both...
Forecasts of affect associated with future positive events tend to be overly optimistic. In 2 experiments we examined the influence thinking either concretely or abstractly on ratings anticipated enjoyment a prototypically activity. 1 study primed low-level construal, and in provided details event. both experiments, for event were lower participants who considered task than those not activity abstractly. Findings suggested that priming construal considering concrete may overestimates pleasure events.
Immune-mediated coronary spasm, called Kounis syndrome (KS), is not rare but underdiagnosed. In this report, we present a case of KS induced by iodinated contrast resulting in cardiac arrest, requiring temporary mechanical circulatory support. We show angiographic evidence and outline commonly associated clinical features that may predict KS. (Level Difficulty: Beginner.).
We previously isolated a 6.1-Mb region of SS/Mcwi (Dahl salt-sensitive) rat chromosome 12 (13.4-19.5 Mb) that significantly elevated blood pressure (BP) (Δ+34 mmHg, P < 0.001) compared with the SS-12(BN) consomic control. In present study, we examined role vascular dysfunction and remodeling in hypertension risk associated locus on by reducing dietary salt, which lowered BP levels so there were no substantial differences between strains. Consequently, any observed vasculature considered...
Background: Paravalvular leak (PVL) is a frequent TAVR complication. Prospective identification of patients who are likely to develop PVL after would lead improved outcomes. Prior studies have used geometric characteristics predict the likelihood development, but prediction and quantification has not been done. One reasons that it difficult mechanical deformation native diseased aortic valve prior implantation prosthetic valve, as existing calcifications contribute seal between annulus....
Premature Ventricular Complexes (PVCs) refer to electrical activity arising from ventricles resulting in ventricular contraction independent of the native rhythm. PVCs by themselves are common general population but based on origin PVCs, either related anatomical or substrate, disease process has a widely varied presentation and prognosis. The clinical symptoms may vary being extremely benign, very severe (malignant). Benign include those that asymptomatic induce mild including palpitations,...