A5007819865- Dialysis and Renal Disease Management
- Body Composition Measurement Techniques
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Central Venous Catheters and Hemodialysis
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Muscle and Compartmental Disorders
- Long-Term Effects of COVID-19
- Potassium and Related Disorders
- Heart Rate Variability and Autonomic Control
- Renal function and acid-base balance
- Non-Invasive Vital Sign Monitoring
- Health Systems, Economic Evaluations, Quality of Life
- Diversity and Career in Medicine
- Transplantation: Methods and Outcomes
- Apelin-related biomedical research
- Electrolyte and hormonal disorders
- Sodium Intake and Health
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Sex and Gender in Healthcare
- Diabetes Management and Research
- Chronic Kidney Disease and Diabetes
Medical University of Vienna
2022-2024
SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound of the "alternative" (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective 1-7. Using mass spectrometry, we assessed key metabolites classical RAS (angiotensins I-II) and alt-RAS 1-7 1-5) pathways as well ACE concentrations in 159 patients hospitalized with COVID-19, stratified disease severity (severe, n = 76; non-severe: 83). Plasma renin...
Abstract Aims Chronic kidney disease (CKD) and obesity are major global health challenges, eventually leading to replacement therapy (KRT), but body mass index (BMI) thresholds hinder transplantation. Glucagon‐like peptide‐1 receptor agonists induce weight loss, thereby offering attractive treatment options; however, their safety efficacy have not been systematically investigated in patients undergoing dialysis. Materials Methods We conducted a prospective 12‐week, open‐label trial with 13...
Abstract Objective: Bioimpedance spectroscopy (BIS) is a non-invasive diagnostic tool to derive fluid volume compartments from frequency dependent voltage drops in alternating currents by extrapolating the extracellular resistance (R0) and intracellular (Ri). Here we tested whether novel BIS device with reusable adhesive single-use electrodes produces results which are (in various body positions) equivalent an established system employing only electrodes.
Approach: Two devices...
Chronic kidney disease (CKD) in stages 3-5 without albuminuria occurs more often women than men; however, most patients initiating and receiving replacement therapy are men. Sex-determined biological factors gender-related aspects both likely account for this discrepancy. Patient opinions on discrepancies care have not been investigated.
Current estimation of body fluid volumes in hemodialysis patients using bioimpedance analysis assumes constant specific electrical characteristics biological tissues despite a large variation plasma Na+ concentrations [Na+], ranging from 130 to 150 mmol/L. Here, we examined the potential effect variable [Na+] on bioimpedance-derived volume overload.Volumes were calculated published whole-body extra- and intracellular resistance data relationships either "standard" or "revised" modeled as...
Prescribing the ultrafiltration in hemodialysis patients remains challenging and might benefit from information on absolute blood volume, estimated by intradialytic dialysate bolus administration. Here, we aimed at determining relationship between normalized for body mass (specific Vs), ultrafiltration-induced decrease relative volume (∆RBV) as well clinical parameters including index (BMI).This retrospective analysis comprised 77 who had their bolus-based extracted routinely with an...
Short-term variability in body mass is a common, everyday phenomenon; however, data on are scarce. While the physiological of negligible healthy individuals, it could have implications for therapy patients with impaired volume homeostasis, example, kidney failure undergoing replacement therapy. We analyzed long-term dataset comprising 9521 days standardized measurements from one male individual and assessed as positive or negative relative difference measured subsequent days. The average...
Individuals with kidney disease receiving maintenance hemodialysis exhibit improved survival higher baseline body mass index and weight gain over time (1Kalantar-Zadeh K. Kopple J.D. Kilpatrick R.D. McAllister C.J. Shinaberger C.S. Gjertson D.W. et al.Association of Morbid Obesity Weight Change Over Time With Cardiovascular Survival in Hemodialysis Population.Am J Kidney Dis. 2005 Sep; 46: 489-500Abstract Full Text PDF PubMed Scopus (253) Google Scholar). This reversal risk factors compared...
Hemodialysis relies on accurate body mass (BM) assessment to determine ultrafiltration volumes, but we have not identified published practice patterns disclosing how handle clothing mass. Here investigated the potential impact of predialysis BM determination, hypothesizing that a standardized template for estimation enhances accuracy, compared with conventional practice.
Abstract Background and Aims Kidney transplant recipients are at risk for glucometabolic deterioration. While many individuals recover their glycemic profiles, some develop posttransplant diabetes mellitus (PTDM). Previous reports have shown that PTDM is associated with increased cardiovascular disease (CVD) mortality. Here we aimed assessing the association of development CVD in kidney from a randomized trial. Method functioning graft (WFG), all-cause death WFG death-censored loss were...
Abstract Background and Aims Measures of non-invasive pulse wave (PW) analysis can help to assess the status central cardiovascular system predict clinical outcomes, including morbidity mortality. During hemodialysis (HD), fluid is extracted from blood. The resulting reduction in relative blood volume (RBV) collected ultrafiltration (UFV) were hypothesized substantially influence PW characteristics during HD. Volume overload (VO) common HD patients may affect chance improving present study...
Abstract Background and Aims Bioimpedance-spectroscopy-(BIS)-derived estimates of fluid status body composition are associated with mortality in patients undergoing maintenance hemodialysis (HD). Previously, thresholds for improved survival were identified volume overload (VO, <2.5 L), VO relative to extracellular water (VO/ECW, <15%), lean tissue index (LTI, 15-20 kg/m2) fat (4-15 kg/m2). However, these did not distinguish between sexes. Considering current efforts untangle...
Abstract Background and Aims Bioimpedance spectroscopy (BIS) is a non-invasive diagnostic tool to assess volume status body composition through the measurement of voltage drops in alternating currents subsequent extrapolation extracellular (R0), intracellular (Ri), total (RInf) resistances. Currently available devices mostly rely on disposable electrodes require supine position. Here we tested whether new, more versatile BIS device with reusable matches an established system various setups,...
A feasible method has recently been proposed for estimating absolute blood volume (ABV) in hemodialysis (HD) patients based on intradialytic infusion of a dialysate bolus and visual assessment the subsequent increase relative (RBV) tracked by dialysis machine. The aim this study was to develop more objective determination such RBV improve accuracy ABV estimation. We numerical algorithm consisting interpolation polynomial fitting signals, which we evaluated data from 64 HD sessions 48 with...
<title>Abstract</title> <bold>Introduction: </bold>SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound of the “alternative” (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective 1-7.<bold>Methods:</bold> Using mass spectrometry, we assessed key metabolites classical RAS (angiotensins I–II) and alt-RAS 1-7 1-5) pathways as well ACE concentrations in 159 patients hospitalized with COVID-19,...
Abstract Introduction: SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound of the “alternative” (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective 1–7. Methods Using mass spectrometry, we assessed key metabolites classical RAS (angiotensins I–II) and alt-RAS 1–7 1–5) pathways as well ACE concentrations in 159 patients hospitalized with COVID-19, stratified disease severity (severe, n = 76;...