A5031339445- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Urinary Tract Infections Management
- Alcohol Consumption and Health Effects
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Urinary and Genital Oncology Studies
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Minimally Invasive Surgical Techniques
- Peroxisome Proliferator-Activated Receptors
- Urological Disorders and Treatments
- Bacterial Identification and Susceptibility Testing
- Pelvic floor disorders treatments
- Multiple and Secondary Primary Cancers
- Adrenal and Paraganglionic Tumors
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Fibroblast Growth Factor Research
Hiroshima University Hospital
2018-2025
Hiroshima University
2015-2025
Kyushu University
2021-2022
Japanese Urological Association
2021
Kure Medical Center
2019
Yodogawa Christian Hospital
2018
Ishikawa Prefectural Central Hospital
2017
Hiroshima City Asa Citizens Hospital
2014
Saiseikai Nakatsu Hospital
2013
Matsuyama Red Cross Hospital
2010
Background: The field of robotic surgery is still continuously advancing, with several cutting-edge systems currently under development. This study aimed to present the methodology and perioperative outcomes robot-assisted radical cystectomy (RARC) intracorporeal urinary diversion (ICUD) in patient muscle invasive bladder cancer (MIBC) by utilizing hinotori Surgical Robot System, a recently developed surgical platform.
Background: Endotoxin plays an important role in the initiation and aggravation of alcoholic liver disease. In this study, we evaluated plasma endotoxin levels serum concentrations cytokines lipopolysaccharide binding protein (LBP) during acute recovery phase patients with hepatitis; also explored prognostic factors associated a fatal outcome. Methods: Fourteen patients, consisting eight hepatitis (AH), five cirrhotics superimposed AH (LC+AH), one patient severe (SAH), were studied. Among...
Fibroblast growth factor (FGF) signaling pathways have been reported to play important roles in prostate cancer (PCa) progression. FGF19 is one of a subfamily FGFs that circulate serum and act an endocrine manner. Our objective was investigate its role the progression PCa.The effect on proliferation epithelial-mesenchymal transition LNCaP PC3 cells examined using MTT assay Western blotting. Serum concentration measured by ELISA 209 patients with PCa, association between clinicopathological...
Chronic kidney disease (CKD) is a risk factor for bladder cancer (BC) and reportedly involved in its recurrence progression. This study aimed to determine the molecular mechanisms underlying development of BC patients with CKD. First, we generated CKD mouse model according unilateral two-stage renal ischemia-reperfusion injury protocol using wild-type C57BL/6 mice. Second, conducted functional analysis DGKα investigated contribution cell invasion, migration, proliferation activity human...
ABSTRACT Introduction Robot‐assisted simple prostatectomy is associated with better perioperative outcomes than those of open prostatectomy. We report the two cases treated robot‐assisted Case Presentation The first patient was an 81‐year‐old man a prostate volume 139 mL. second 77‐year‐old 98 performed using Da Vinci Xi. operative times and enucleated weights for patients were 210 min 82 g, 191 53 respectively. Postoperative uroflowmetry revealed maximum flow rates postvoid residual volumes...
ABSTRACT Introduction Laparoscopic adrenalectomy is a common procedure for the treatment of adrenal tumors. However, recent inclusion robotic in list insurance‐covered procedures Japan since April 2022 has raised questions regarding its broader clinical utility. This study aimed to elucidate outcomes and conduct comprehensive analysis comparing laparoscopic adrenalectomies. Methods The baseline characteristics patients perioperative between adrenalectomies performed at Hiroshima University...
Mycoplasma hominis, Ureaplasma parvum, and urealyticum are commensal bacteria that associated with colonization infection of the urogenital tract. However, respiratory tract by these microorganisms in adults has not been fully investigated.Urine samples (sputum, tracheal aspirates, bronchoalveolar lavage) patients aged 20-80 years were analyzed to detect presence M. U. using a conventional PCR method. The submitted microbiological clinical laboratory Hiroshima University Hospital from...
Therapeutic hypothermia is recommended for moderate and severe neonatal encephalopathy, but being applied to a wider range of neonates than originally envisaged. To examine the clinical use therapeutic hypothermia, data collected during first 3 years (2012-2014) Baby Cooling Registry Japan were analysed. Of 485 cooled neonates, 96.5% ≥36 weeks gestation 99.4% weighed ≥1,800 g. Severe acidosis (pH < 7 or base deficit ≥16 mmol/L) was present in 68.9%, 96.7% required resuscitation >10 min....
<b><i>Introduction:</i></b> BUB1 mitotic checkpoint serine/threonine kinase B encoded by <i>BUB1B</i> gene is a member of the spindle assembly family. Several reports have demonstrated that overexpression BUB1B associated with cancer progression and prognosis. <b><i>Objective:</i></b> This study aims to clarify expression function in renal cell carcinoma (RCC). <b><i>Methods:</i></b> The was determined using...
To investigate the impact of pretreatment serum C-reactive protein (CRP) level and its change after targeted therapy on anti-tumour effect agents in patients with metastatic renal cell carcinoma (mRCC).The CRP 190 cases molecular for mRCC was measured before starting prescription when computed tomography showed maximum effect. Patients which ≥0.5 mg/dL were classified into a 'higher-CRP' group others 'lower-CRP' group. The higher-CRP further two subgroups, i.e. those whose decreased...
Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is reported to play an essential role in cancer. This study aimed analyze KIFC1 expression and examine involvement cisplatin resistance bladder cancer (BC). Immunohistochemistry showed that 37 of 78 (47.4%) BC cases were positive for KIFC1. KIFC1-positive associated with high T stage lymph node metastasis. Kaplan-Meier analysis poor prognosis, consistent the results from public databases. Molecular classification several...
The carcinogenesis and progression of renal cell carcinoma (RCC), a heterogeneous cancer derived from tubular epithelial cells, is closely related to oxidative stress responses (OSRs). Oxidative participate in various biological processes the metabolism metastatic potential such as inflammation, epithelial-mesenchymal transition (EMT), angiogenesis. In this study, we investigated role broad complex-tramtrack-bric-a-brac cap 'n' collar homology 1 (BACH1), key transcription factor for OSRs,...
Abstract Background Vagococcal infections are extremely rare in humans. There limited studies on the optimal methods for identification, antimicrobial susceptibility testing, and clinical manifestations of vagococcal infections. Herein, we report a patient with urinary tract infection who had Vagococcus fluvialis urine. Case presentation An 84-year-old man presented to our urology department fever that persisted several days. He previously worked as zoo clerk. The underwent left...
Palytoxin (PTX), C129H223O3N54, isolated from marine coelenterates of Palythoa tuberculosa, caused contraction the human umbilical artery in a dose-dependent manner (10(-11)-10(-8) M). Pretreatment with ouabain (10(-5) M) abolished PTX (10(-8) M)-induced but had no effect on serotonin- (10(-6) and potassium- (40 mM) induced contractions. When muscle was exposed to potassium-free medium, application able cause similar normal medium. In presence verapamil (3 X 10(-6) or calcium-free...
<b><i>Background:</i></b> βIII-Tubulin, encoded by the <i>TUBB3</i> gene, is a microtubule protein. Several studies have shown that overexpression of TUBB3 linked to poor prognosis and involved in taxane resistance some cancers. <b><i>Objective:</i></b> The aim this study was analyze expression function clear cell renal carcinoma (ccRCC). <b><i>Methods:</i></b> determined using immunohistochemistry ccRCC...
Little is known about endotoxin clearance and secretion of cytokines from macrophages in liver cirrhosis. The aims this study were to investigate the relationship release tumor necrosis factor alpha by various hepatic renal disturbances cirrhosis.Male Sprague-Dawley rats given 0.04% thioacetamide orally for 6 or 12 months. organ distribution infused [3H]-endotoxin (10 microg/kg b.w.) was analyzed at 30 min 24 h. Uptake Kupffer cells, splenic peripheral blood monocytes (1 x 10(4) cells/ml)...
Objectives This study aimed to investigate the characteristics of patients who report improvement in quality life (QOL) related urinary status after undergoing robot‐assisted radical prostatectomy (RARP) for localized prostate cancer. Methods We retrospectively reviewed underwent RARP between May 2010 and 2021 at our institution were preoperatively unsatisfied with their status. Patients grouped as Group 1 (improved patients: “satisfied” based on international symptom score QOL [IPSS‐QOL] =...
Severe alcoholic liver injury has been relatively rare, but is gradually increasing in Japan. The clinical features and prognostic factors severe were retrospectively investigated 105 patients, consisting of 3 with hepatitis (SAH), 43 cirrhosis superimposed [liver (LC) +alcoholic (AH)], 38 AH, 21 cirrhosis. Seven the patients (6.7%, 2 SAH 5 LC+AH) died hepatic failure. Patients showed hyperbilirubinemia, reduced biosynthetic capacity, marked acute inflammatory reactions, developed multiple...
In the present study, role of albumin and high-density lipoprotein (HDL) as endotoxin (Et)-binding proteins in chronically alcohol-fed rats was studied. acute ethanol-loaded rats, Et clearance blood slightly prolonged, amount HDL- bound markedly increased. chronic significantly faster than that control, HDL-bound ethanol-fed with an additional 5 g/kg body weight ethanol load, much tumor necrosis factor ALT elevated, when not further Et-binding capacity total proteins, albumin, HDL hepatocyte...