A5090412329- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Fuel Cells and Related Materials
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- Electrochemical Analysis and Applications
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
- Electron Spin Resonance Studies
- Ion Transport and Channel Regulation
- Cardiomyopathy and Myosin Studies
- Analytical Methods in Pharmaceuticals
- Genomics and Rare Diseases
- Genetic Associations and Epidemiology
- stochastic dynamics and bifurcation
- ATP Synthase and ATPases Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Microbial Inactivation Methods
- Kruppel-like factors research
- Bioinformatics and Genomic Networks
- Connexins and lens biology
- Fault Detection and Control Systems
Université Claude Bernard Lyon 1
1983-2022
Centre National de la Recherche Scientifique
2005-2022
Inserm
1990-2022
CEA Grenoble
2005-2006
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2005-2006
Institut de Biologie Structurale
2005
Université Grenoble Alpes
2005
Université Joseph Fourier
2001
Délégation Régionale Auvergne-Rhône-Alpes
1995-1999
Groupe Lépine (France)
1989
Genome-wide association studies (GWAS) have identified thousands of genetic variants linked to the risk human disease. However, GWAS so far remained largely underpowered in relation identifying associations rare and low-frequency allelic spectrum lacked resolution trace causal mechanisms underlying genes
Vascular endothelial-cadherin (VE-cadherin) plays a key role in angiogenesis and vascular permeability. The regulation of its biological activity may be central mechanism normal or pathological angiogenesis. VE-cadherin has been shown to phosphorylated on tyrosine vitro under various conditions, including stimulation by VEGF. In the present study, we addressed question existence form vivo, correlation with quiescent versus angiogenic state adult tissues. Phosphorylated was detected mouse...
Mortality rate is high in psychiatric patients versus general population. An important cause of this increased mortality sudden cardiac death (SCD) as a major side-effect psychotropic drugs. These SCDs generally result from arrhythmias occurring when the posology and may attain toxic threshold but also at dosages within therapeutic range, presence risk factors. There are three kinds factors: physiological (e.g., low sportsmen), physiopathological hepatic insufficiency, hypothyroidism)...
The morphology of the cardiac transverse-axial tubular system (TATS) has been known for decades, but its function received little attention. To explore possible role this in physiological modulation electrical and contractile activity, we have developed a mathematical model rat ventricular cardiomyocytes which TATS is described as single compartment. geometrical characteristics TATS, biophysical ion transporters their distribution between surface membranes were based on available...
Long QT syndrome (LQTS) is a congenital abnormality of cardiac repolarization that manifests as prolonged interval on 12-lead electrocardiograms (ECGs). The may lead to syncope and sudden death from ventricular tachyarrhythmias known torsades de pointes. An increased persistent Na(+) current cause Ca(2+) overload in case ischemia for example. Such also usually associated the LQT3 syndrome. purpose this study was investigate pathological consequences novel mutation family affected by LQTS....
Ventricular and Purkinje action potentials were recorded with a microelectrode in strip of human papillary muscle. Lowering the K-content superfusing solution from 5.9 to 0.5 mmol·litre−1 at 37°C hyperpolarised ventricular diastolic potential steadily as long [K+]o was low (up 70 min tested). transiently lengthened then shortened. A positive inotropic effect noted attributed Na-K pump inhibition since it reversed by addition 2 thallous chloride solution. Beyond 40 min, transient...
We have developed a computer model of human cardiac ventricular myocyte (CVM), including t-tubular and cleft spaces with the aim evaluating impact accumulation-depletion ions in restricted extracellular on transmembrane ion transport ionic homeostasis CVM. The was based available data from CVMs. Under steady state, effect concentration changes [Ca2+]i-transient explored as function critical fractions transporters membrane (not documented for CVM). Depletion Ca2+ accumulation K+ occurring...
The ratio of densities Na-Ca exchanger current (INaCa) in the t-tubular and surface membranes (INaCa-ratio) computed from values INaCa membrane capacitances (Cm) measured adult rat ventricular cardiomyocytes before after detubulation ranges between 1.7 25 (potentially even 40). Variations action potential waveform calcium turnover within this span INaCa-ratio were simulated employing previously developed model cell incorporating separate description ion transport systems membranes. increase...
1 Electrophysiological effects of endothelin-1 (ET-1) were studied in rabbit sinoatrial node (SAN) using conventional microelectrode and whole-cell voltage current recordings. 2 In SAN, RT-PCR detected ETA endothelin receptor mRNA. ET−1 (100 nm) increased the cycle length action potentials (APs) from 305 ± 15 to 388 25 ms; this effect was antagonised by receptor-selective antagonist BQ−123 (1 μm). ET-1 AP duration (APD50) 22 %, depolarised maximum diastolic potential (MDP) −59 −53 mV,...
Abstract An in vitro method has been developed for human non‐anticoagulated blood to evaluate the enhancing effect of hemostatic agents on both plasmatic and cellular activation coagulation cascade. The time sequential generation fibrinopeptide A (FpA) have used as parameters. kinetics FpA modelized mathematically analyzed using latence time, slope linear part curve, necessary reach half maximal amplitude tube. very precise evaluation activity five different molecules, four being collagenous...