A5088096340- Neuroscience and Neuropharmacology Research
- RNA and protein synthesis mechanisms
- Zebrafish Biomedical Research Applications
- RNA Research and Splicing
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Biochemical Analysis and Sensing Techniques
- Hearing, Cochlea, Tinnitus, Genetics
- RNA regulation and disease
- GABA and Rice Research
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroscience of respiration and sleep
- melanin and skin pigmentation
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Genomics and Chromatin Dynamics
- Receptor Mechanisms and Signaling
Sarah Lawrence College
2019-2023
Linfield College
2017-2023
Brown University
2013-2021
Vollum Institute
2015
Oregon Health & Science University
2015
The senses of hearing and balance are subject to modulation by efferent signaling, including the release dopamine (DA). How DA influences activity auditory vestibular systems its site action not well understood. Here we show that dopaminergic fibers innervate acousticolateralis epithelium zebrafish during development but do directly form synapses with hair cells. However, a member D1-like receptor family, D1b, tightly localizes ribbon in inner ear lateral-line To assess hair-cell activity,...
Abstract The majority of multiexon mammalian genes contain alternatively spliced exons that have unique expression patterns in different cell populations and important functions. profiles alternative are controlled by cell-specific splicing factors can promote exon inclusion or skipping but with few exceptions we do not know which specific control the known biological function. Many ion channel undergo extensive including Cacna1b encodes voltage-gated Ca V 2.2 α1 subunit. Alternatively 18a...
The superfamily of Cys-loop ionotropic neurotransmitter receptors includes those that detect GABA, glutamate, glycine, and acetylcholine. There is ample evidence many receptor subunit genes include alternatively spliced exons. In this study, we report a novel example alternative splicing (AS): show the 68-bp exon 3 in zebrafish gabrr2b gene—which codes for ρ2b GABAAR subunit—is an cassette exon. Skipping results downstream frame shift premature termination codon (PTC). We provide larval...