A5102007648- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Motor Control and Adaptation
- High Altitude and Hypoxia
- Cardiovascular and exercise physiology
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Nerve Injury and Rehabilitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pain Management and Treatment
- Functional Brain Connectivity Studies
- Respiratory Support and Mechanisms
- Spinal Cord Injury Research
- Sports Performance and Training
- Intraoperative Neuromonitoring and Anesthetic Effects
- Body Composition Measurement Techniques
- Workplace Health and Well-being
- Neural and Behavioral Psychology Studies
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neural Engineering
MetroHealth Medical Center
2018-2025
Metro Health Hospital
2025
Case Western Reserve University
2018-2025
MetroHealth
2018-2025
Louis Stokes Cleveland VA Medical Center
2020-2025
Cleveland Clinic
2013-2025
Cleveland FES Center
2022-2024
University School
2023
Cleveland Clinic Lerner College of Medicine
2013-2022
Kessler Foundation
2016-2017
Upper-extremity impairment after stroke remains a major therapeutic challenge and target of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with renewed physical rehabilitation promote functional reorganization ipsilesional cortex in 12 individuals persistent (1-3 years), moderate-to-severe upper-extremity impairment. No serious perioperative or stimulation-related adverse events...
Journal Article Determinants of Self-Selected Walking Pace Across Ages 19 to 66 Get access D. A. Cunningham, PhD, PhD 2Requests for Reprints Should Be Addressed Dr. Cunningham. The Faculties Physical Education and Medicine. Medical Sciences Building. the University Western OntarioLondon, Ontario. Canada N6A 5C1 Search other works by this author on: Oxford Academic PubMed Google Scholar P. Rechnitzer, MD, MD M. E. Pearce, MA, MA Donner, Gerontology, Volume 37, Issue 5, September 1982, Pages...
Aerobic exercise may acutely prime the brain to be more responsive rehabilitation, thus facilitating neurologic recovery from conditions like stroke. This aerobic priming effect could occur through multiple mechanisms, including upregulation of circulating brain-derived neurotrophic factor (BDNF), increased corticospinal excitability, and decreased intracortical inhibition. However, optimal parameters for targeting these mechanisms are poorly understood. study tested effects intensity on...
Managers (236) from 12 different companies were examined for the prevalence of Type A behavior. In addition, a number work habits and job related variables (work hours per week, travel habits, satisfaction, tension factors, salary) obtained on each respondent. Overall, 61% managers classified as A's, between percentage varied 50 76%. behavior was also found to be recent company growth rates. On it that extreme 's tend more week days year. It less satisfied with their jobs. Using factor...
Stimulating the brain to drive its adaptive plastic potential is promising accelerate rehabilitative outcomes in stroke. The ipsilesional primary motor cortex (M1) invariably facilitated. However, evidence supporting efficacy divided, indicating that we may have overgeneralized potential. Since M1 and corticospinal output are frequently damaged patients with serious lesions impairments, premotor areas (PMAs) could be useful alternates instead. We base our premise on their higher probability...
To demonstrate, in a proof-of-concept study, whether potentiating ipsilesional higher motor areas (premotor cortex and supplementary area) augments accelerates recovery associated with constraint induced movement.In randomized, double-blinded pilot clinical 12 patients chronic stroke were assigned to receive anodal transcranial direct current stimulation (tDCS) (n = 6) or sham the during constraint-induced movement therapy. We assessed functional neurophysiologic outcomes before after 5...
OBJECTIVES: To study the potential usefulness of a submaximal self‐paced step test as prediction maximal aerobic capacity (VO 2 max) in older adults primary care setting. DESIGN: Data were collected during prospective randomized an exercise program. SETTING: Four university family medical clinics London, Ontario, Canada. PARTICIPANTS: A random sample 240 healthy (≥65) men (n = 118) and women 122) from four underwent testing clinic with physician 16), treadmill measurement respired gases...
The purpose of this study was to compare strength, flexibility, and cardiorespiratory fitness the elderly living independently (n = 64) with those in rest or nursing homes 61), identify variables most strongly associated an independent lifestyle. Quantitative levels independence (Incapacity Index) activity were determined by questionnaires. Flexibility measured using Leighton Flexometer. Strength a modified sphygmomanometer. Cardiorespiratory self-paced walking test. Body size factors also...
The pain matrix is comprised of an extensive network brain structures involved in sensory and/or affective information processing.The thalamus a key structure constituting the matrix.The serves as relay center receiving from multiple ascending pathways and relating to cortical areas.However, it unknown how thalamocortical networks specific sensory-affective processing are functionally integrated.Here, proof-of-concept study healthy humans, we aimed understand this connectivity using...
BACKGROUND: Recruitment curves (RCs) acquired using transcranial magnetic stimulation are commonly used in stroke to study physiologic functioning of corticospinal tracts (CST) from M1. However, it is unclear whether CSTs higher motor cortices contribute as well. OBJECTIVE: To explore integrity CST areas, besides M1, relates captured RCs. METHODS: RCs were for a paretic hand muscle patients with chronic stroke. Metrics describing gain and overall output collected. was defined by diffusion...
Transcranial direct current stimulation (tDCS) targeting the primary motor cortex is modestly effective for promoting upper-limb function following stroke. The premotor (PMC) represents an alternative target based on its higher likelihood of survival and dense motor-network connections.
We tested the hypothesis that integrated sympathetic and cardiovascular reflexes are modulated by systemic CO 2 differently in hypoxia than hyperoxia (n = 7). Subjects performed a rebreathe protocol equilibrates partial pressures between arterial venous blood elevates end tidal (PET CO2 ) from ~40 to ~58 mmHg. This test was repeated under conditions where oxygen levels were clamped at 50 (hypoxia) or 200 (hyperoxia) Heart rate (HR; EKG), stroke volume (SV; Doppler ultrasound), pressure (MAP;...
Our goal was to determine if pairing transcranial direct current stimulation (tDCS) with rehabilitation for two weeks could augment adaptive plasticity offered by these residual pathways elicit longer-lasting improvements in motor function incomplete spinal cord injury (iSCI).Longitudinal, randomized, controlled, double-blinded cohort study.Cleveland Clinic Foundation, Cleveland, Ohio, USA.Eight male subjects chronic tetraplegia.Massed practice (MP) training or without tDCS 2 hrs, 5 times a...
Background. Upper-limb chronic stroke hemiplegia was once thought to persist because of disproportionate amounts inhibition imposed from the contralesional on ipsilesional hemisphere. Thus, one rehabilitation strategy involves discouraging engagement hemisphere by only engaging impaired upper limb with intensive unilateral activities. However, this premise has recently been debated and shown be task specific and/or apply a subset population. Bilateral rehabilitation, conversely, engages both...
Abstract Objective: Ipsilateral motor evoked potentials (iMEPs) are believed to represent cortically excitability of uncrossed brainstem-mediated pathways. In the event extensive injury (crossed) corticospinal pathways, which can occur following a stroke, ipsilateral pathways may serve as an alternate resource support recovery paretic limb. However, iMEPs, even in neurally intact people, be small, infrequent, and noisy, so discerning them stroke survivors is very challenging. This study...
ABSTRACT The cerebellum acts as a forward internal model to predict motor outcomes, compare them with sensory feedback, and generate prediction errors that refine accuracy. Our physiological understanding of cerebellar function during control derives predominantly from animal experiments clinical observations in patients disorders the or its connections cerebrum spinal cord. Here, we report human electrophysiology‐based investigation cerebello‐thalamo‐cortical pathway activity error...